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Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation

  • Original Article
  • Published:
International Journal of Public Health

Abstract

Objective

The Mashhad stroke and heart atherosclerotic disorder (MASHAD) study is a 10-year cohort study that aims to evaluate the impact of various genetic, environmental, nutritional and psychosocial risk factors on the incidence of cardiovascular events among an urban population in eastern Iran.

Methods

The MASHAD study comprises a cohort of 9704 individuals aged 35–65 years using a stratified cluster random sampling design. This cohort will be followed up until 2020, with follow-up examinations being undertaken every 3 years. Ten-year cardiovascular disease (CVD) risk estimation was determined using NCEP ATP III criteria.

Results

Overall, 88.4 % of women and 79.2 % of men (P < 0.001) had at least one lipid abnormality. The 10-year risk for CVD of <10, 10–20 and >20 % were observed to be 86.6, 11 and 2.5 %, respectively. Predicted risk of CVD > 10 % using the Framingham algorithm was considerably higher in men compared to women. Overall, 9.5 % [95 % confidence interval (CI) 8.9–10.1 %] of our subjects had prevalent CAD.

Conclusion

The prevalence of CVD risk factors within our population is high compared to Western countries, indicating the necessity for interventional risk modifications.

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Conflict of interest

Authors have no conflict of interest to disclose.

Author information

Authors and Affiliations

  1. Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Ghayour-Mobarhan, Mohsen Moohebati, Habibollah Esmaily, Seyed Mohammad Reza Parizadeh, Mohammad Safarian, Mohsen Nematy, Maryam Mohammadi & Mohammad Sobhan Sheikh Andalibi

  2. Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Ghayour-Mobarhan, Mohsen Moohebati, Mahmoud Ebrahimi, Ali Reza Heidari-Bakavoli & Mahmoud Reza Azarpazhooh

  3. Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran

    Habibollah Esmaily

  4. Psychiatry and Behavioral Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Naghmeh Mokhber

  5. Department of Epidemiology, Boston University School of Public Health, Boston, USA

    Hamidreza Saber

  6. Division of Medical Education, Brighton and Sussex Medical School, University of Brighton, Rm 342, Mayfield House, Brighton, BN1 9PH, UK

    Gordon A. Ferns

Authors
  1. Majid Ghayour-Mobarhan
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  2. Mohsen Moohebati
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  3. Habibollah Esmaily
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  4. Mahmoud Ebrahimi
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  5. Seyed Mohammad Reza Parizadeh
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  6. Ali Reza Heidari-Bakavoli
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  7. Mohammad Safarian
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  8. Naghmeh Mokhber
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  9. Mohsen Nematy
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  10. Hamidreza Saber
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  11. Maryam Mohammadi
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  12. Mohammad Sobhan Sheikh Andalibi
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  13. Gordon A. Ferns
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  14. Mahmoud Reza Azarpazhooh
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Corresponding author

Correspondence to Mahmoud Reza Azarpazhooh.

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Ghayour-Mobarhan, M., Moohebati, M., Esmaily, H. et al. Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation. Int J Public Health 60, 561–572 (2015). https://doi.org/10.1007/s00038-015-0679-6

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  • DOI: https://doi.org/10.1007/s00038-015-0679-6

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