Original Article

International Journal of Public Health

, Volume 58, Issue 5, pp 757-764

The use of household cleaning products during pregnancy and lower respiratory tract infections and wheezing during early life

  • Lidia CasasAffiliated withCentre for Research in Environmental Epidemiology (CREAL)Hospital del Mar Research Institute (IMIM)CIBER Epidemiología y Salud Pública (CIBERESP) Email author 
  • , Jan Paul ZockAffiliated withCentre for Research in Environmental Epidemiology (CREAL)Hospital del Mar Research Institute (IMIM)CIBER Epidemiología y Salud Pública (CIBERESP)
  • , Anne Elie CarsinAffiliated withCentre for Research in Environmental Epidemiology (CREAL)Hospital del Mar Research Institute (IMIM)CIBER Epidemiología y Salud Pública (CIBERESP)
  • , Ana Fernandez-SomoanoAffiliated withCIBER Epidemiología y Salud Pública (CIBERESP)University of Oviedo
  • , Ana EspluguesAffiliated withCIBER Epidemiología y Salud Pública (CIBERESP)Center for Public Health Research-CSISP
  • , Loreto Santa-MarinaAffiliated withCIBER Epidemiología y Salud Pública (CIBERESP)Subdirección de Salud Pública de Gipuzkoa, Departamento de Sanidad, Gobierno VascoInstituto de Investigación Sanitaria Biodonostia
  • , Adonina TardónAffiliated withCIBER Epidemiología y Salud Pública (CIBERESP)University of Oviedo
  • , Ferran BallesterAffiliated withCIBER Epidemiología y Salud Pública (CIBERESP)Center for Public Health Research-CSISPUniversity of Valencia
  • , Mikel BasterrecheaAffiliated withCIBER Epidemiología y Salud Pública (CIBERESP)Subdirección de Salud Pública de Gipuzkoa, Departamento de Sanidad, Gobierno VascoInstituto de Investigación Sanitaria Biodonostia
    • , Jordi SunyerAffiliated withCentre for Research in Environmental Epidemiology (CREAL)Hospital del Mar Research Institute (IMIM)CIBER Epidemiología y Salud Pública (CIBERESP)Pompeu Fabra University

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Abstract

Objective

To evaluate the effects of household use of cleaning products during pregnancy on infant wheezing and lower respiratory tract infections (LRTI).

Methods

In four prospective Spanish birth cohorts (n = 2,292), pregnant women reported the use of household cleaning products. When infants were 12–18 months old, current cleaning product use and infant’s wheezing and LRTI were reported. Cohort-specific associations between the use of specific products and respiratory outcomes were evaluated using multivariable regression analyses and estimates were combined using random-effects meta-analyses.

Results

The period prevalence of LRTI was higher when sprays (combined odds ratio (OR) = 1.29; 95 % confidence interval (CI) 1.04–1.59) or air fresheners (OR = 1.29; CI 1.03–1.63) were used during pregnancy. The odds of wheezing increased with spray (OR = 1.37; CI 1.10–1.69) and solvent (OR = 1.30; CI 1.03–1.62) use. The associations between spray and air freshener use during pregnancy and both outcomes remained apparent when these products were not used after pregnancy. Nevertheless, the estimates were higher when post-natal exposure was included.

Conclusion

The use of cleaning sprays, air fresheners and solvents during pregnancy may increase the risk of wheezing and infections in the offspring.

Keywords

Household products Respiratory tract infections Wheezing Infant Longitudinal studies