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Small molecules for reprogramming and transdifferentiation

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Abstract

Pluripotency reprogramming and transdifferentiation induced by transcription factors can generate induced pluripotent stem cells, adult stem cells or specialized cells. However, the induction efficiency and the reintroduction of exogenous genes limit their translation into clinical applications. Small molecules that target signaling pathways, epigenetic modifications, or metabolic processes can regulate cell development, cell fate, and function. In the recent decade, small molecules have been widely used in reprogramming and transdifferentiation fields, which can promote the induction efficiency, replace exogenous genes, or even induce cell fate conversion alone. Small molecules are expected as novel approaches to generate new cells from somatic cells in vitro and in vivo. Here, we will discuss the recent progress, new insights, and future challenges about the use of small molecules in cell fate conversion.

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Acknowledgements

This research was supported in part by the National Nature Science Foundation of China (81121004, 81230041) and the National Basic Science and Development Program (973 Program, 2012CB518105).

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  1. Hua Qin and Andong Zhao contributed equally to this work.

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  1. Tianjin Medical University, Tianjin, 300070, China

    Hua Qin & Andong Zhao

  2. Key Laboratory of Wound Repair and Regeneration of PLA, The First Hospital Affiliated to the PLA General Hospital, 51 Fu Cheng Road, Haidian District, Beijing, 100048, China

    Xiaobing Fu

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  1. Hua Qin
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Correspondence to Xiaobing Fu.

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Qin, H., Zhao, A. & Fu, X. Small molecules for reprogramming and transdifferentiation. Cell. Mol. Life Sci. 74, 3553–3575 (2017). https://doi.org/10.1007/s00018-017-2586-x

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