Abstract
Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health.
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Acknowledgements
This research was supported by the MEGAFSHD Grant from the Association Française contre les Myopathies (AFM) to YSV and the Grant No. 16-54-16015 from the Russian Foundation for Basic Research to BC and VZ. VZ acknowledges the André Mazon fellowship from the French embassy in Russia. We thank Ms. Shirmoné Botha for critical reading of the manuscript.
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Bou Saada, Y., Zakharova, V., Chernyak, B. et al. Control of DNA integrity in skeletal muscle under physiological and pathological conditions. Cell. Mol. Life Sci. 74, 3439–3449 (2017). https://doi.org/10.1007/s00018-017-2530-0
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DOI: https://doi.org/10.1007/s00018-017-2530-0