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Deconvoluting the ontogeny of hematopoietic stem cells

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Abstract

Two different models describe the development of definitive hematopoiesis and hematopoietic stem cells (HSCs). In one of these, the visceral yolk sac serves as a starting point of relatively lengthy developmental process culminating in the fetal liver hematopoiesis. In another, the origin of adult hematopoiesis is split between the yolk sac and the dorsal aorta, which has a peculiar capacity to generate definitive HSCs. Despite a large amount of experimental data consistent with the latter view, it becomes increasingly unsustainable in the light of recent cell tracing studies. Moreover, analysis of the published studies supporting the aorta-centered version uncovers significant caveats in standard experimental approach and argumentation. As a result, the theory cannot offer feasible cellular mechanisms of the HSC emergence. This review summarizes key efforts to discern the developmental pathway of the adult-type HSCs and attempts to put forward a hypothesis on the inflammatory mechanisms of hematopoietic ontogenesis.

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Acknowledgments

This work was supported by Science and Technology Planning Project of Guangdong Province, China (2011A060901019).

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  1. Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou, 510530, China

    Igor M. Samokhvalov

  2. Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, 190 Kai Yuan Avenue, Science Park, Guangzhou, 510530, China

    Igor M. Samokhvalov

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Samokhvalov, I.M. Deconvoluting the ontogeny of hematopoietic stem cells. Cell. Mol. Life Sci. 71, 957–978 (2014). https://doi.org/10.1007/s00018-013-1364-7

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