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MicroRNA-mediated gene regulations in human sarcomas

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Abstract

Sarcomas are a heterogeneous group of tumors with mesenchymal origins. Sarcomas are broadly classified into bone and soft tissue sarcomas with over 50 subtypes. Despite recent advances in sarcoma classification and treatment strategies, the prognosis of some aggressive sarcoma types remains poor due to treatment infectiveness and development of drug resistance. A better understanding of sarcoma pathobiology will significantly increase the potential for the development of therapeutics and treatment strategies. Recently, expressions of microRNAs (miRNA), a class of small non-coding RNAs, have been found to be deregulated in many sarcomas and are implicated in sarcoma pathobiology. Comprehensive understanding of gene regulatory networks mediated by miRNAs in each sarcoma type and the conservation of some shared/conserved miRNA-gene networks could be potentially investigated in the prevention, diagnosis, prognosis and as multi-modal treatment options in these cancers. In this review, we will discuss the current knowledge of miRNA–gene regulatory networks in various sarcoma types and give a perspective of the complex multilayer miRNA-mediated gene regulation in sarcomas.

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Acknowledgments

Due to space restrictions, we could not cite many significant contributions made by numerous other investigators in this important and rapidly progressing field. We thank Ms. Jennie W. Knoot for assisting with manuscript editing. This work is supported by grants from Minnesota Medical Foundation, Academic Health Center, University of Minnesota and The Karen Wykoff Sarcoma Foundation and the Department of Defense (W81XwH10-1-0556).

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  1. Department of Surgery, University of Minnesota, 11-212 Moos Tower (Mail Code: MMC 195), 515 Delaware St, S.E, Minneapolis, MN, 55455, USA

    Subbaya Subramanian

  2. Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA

    Subbaya Subramanian

  3. Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA

    Reena V. Kartha

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  1. Subbaya Subramanian
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Correspondence to Subbaya Subramanian.

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Subramanian, S., Kartha, R.V. MicroRNA-mediated gene regulations in human sarcomas. Cell. Mol. Life Sci. 69, 3571–3585 (2012). https://doi.org/10.1007/s00018-012-1127-x

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  • DOI: https://doi.org/10.1007/s00018-012-1127-x

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