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Systems biology for molecular life sciences and its impact in biomedicine

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An Erratum to this article was published on 06 June 2013

Abstract

Modern systems biology is already contributing to a radical transformation of molecular life sciences and biomedicine, and it is expected to have a real impact in the clinical setting in the next years. In this review, the emergence of systems biology is contextualized with a historic overview, and its present state is depicted. The present and expected future contribution of systems biology to the development of molecular medicine is underscored. Concerning the present situation, this review includes a reflection on the “inflation” of biological data and the urgent need for tools and procedures to make hidden information emerge. Descriptions of the impact of networks and models and the available resources and tools for applying them in systems biology approaches to molecular medicine are provided as well. The actual current impact of systems biology in molecular medicine is illustrated, reviewing two cases, namely, those of systems pharmacology and cancer systems biology. Finally, some of the expected contributions of systems biology to the immediate future of molecular medicine are commented.

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Acknowledgments

Our experimental work is supported by grants PS09/02216 (Spanish Ministry of Science and Innovation and FEDER) and PIE P08-CTS-3759, CVI-6585 and funds from group BIO-267 (Andalusian Government and FEDER). The “CIBER de Enfermedades Raras” is an initiative from the ISCIII (Spain).

Conflict of interest

The author declares that there is no conflict of interest.

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  1. Department of Molecular Biology and Biochemistry, University of Málaga, Malaga, Spain

    Miguel Ángel Medina

  2. CIBER de Enfermedades Raras (CIBERER), Málaga, Spain

    Miguel Ángel Medina

  3. Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, 29071, Málaga, Spain

    Miguel Ángel Medina

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  1. Miguel Ángel Medina
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Correspondence to Miguel Ángel Medina.

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Medina, M.Á. Systems biology for molecular life sciences and its impact in biomedicine. Cell. Mol. Life Sci. 70, 1035–1053 (2013). https://doi.org/10.1007/s00018-012-1109-z

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