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Alterations on peripheral blood B cell subsets induced by allergic rhinitis

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Abstract

Objectives and design

Here we evaluated whether allergic rhinitis to Dermatophagoides pteronyssinus induces alterations on circulating B cell subsets.

Materials and methods

Circulating B cell subsets and isotype expression on antigen-experienced B cells from allergic patients under conventional pharmacological treatment (NO-SIT, n = 15) and under subcutaneous immunotherapy (SCIT, n = 33), and non-allergic subjects (NC, n = 25) were analyzed by flow cytometry.

Results

In allergic patients, we found a significant decrease in IgM+ and IgG+ memory B cells and an increase in IgA+ memory B cells. Additionally, the numbers of circulating IgA+ plasmablasts in allergic patients were also increased, while those cells expressing IgM were reduced.

Conclusions

Allergic patients have a disturbed B cell subsets distribution which seems to underlie rhinitis pathogenesis and remain unchanged after SCIT.

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    Authors and Affiliations

    1. Blood and Transplantation Center of Coimbra, Portuguese Institute of Blood and Transplantation, Coimbra, Portugal

      Ana Henriques, Rodrigo Nunes, António Martinho, Maria Pais, Hélder Trindade & Artur Paiva

    2. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal

      Ana Henriques

    3. Escola Superior de Tecnologia da Saúde de Coimbra/Coimbra Health School, Coimbra, Portugal

      Rodrigo Nunes & Artur Paiva

    4. Imunoallergology Department, University Hospital Center of Coimbra, Coimbra, Portugal

      Graça Loureiro, António Segorbe-Luís & Celso Pereira

    Authors
    1. Ana Henriques
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    2. Rodrigo Nunes
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    3. Graça Loureiro
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    4. António Martinho
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    5. Maria Pais
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    6. António Segorbe-Luís
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    7. Hélder Trindade
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    8. Celso Pereira
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    9. Artur Paiva
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    Corresponding author

    Correspondence to Artur Paiva.

    Additional information

    Responsible Editor: Mauro Teixeira.

    A. Henriques and R. Nunes have equally contributed to this work and both should be considered as first author.

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    Henriques, A., Nunes, R., Loureiro, G. et al. Alterations on peripheral blood B cell subsets induced by allergic rhinitis. Inflamm. Res. 64, 145–149 (2015). https://doi.org/10.1007/s00011-015-0803-3

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    • DOI: https://doi.org/10.1007/s00011-015-0803-3

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