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The association between the functional PTPN22 1858 C/T and MIF −173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis

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Abstract

Background

The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T (rs2476601) and macrophage migration inhibitory factor (MIF) −173 C/G polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA).

Methods

A meta-analysis was conducted on variant alleles versus common alleles of the PTPN22 1858 C/T and MIF −173 C/G polymorphisms across ten comparative studies, which containing 4,238 JIA patients and 6,012 normal control subjects.

Results

Ten comparative studies, consisting of nine European, and one Turkish population, were included in his meta-analysis. Meta-analysis showed an association between the T allele of the PTPN22 1858 C/T polymorphism and JIA in Europeans [odds ratio (OR) 1.311, 95% confidence interval (CI) 1.205–1.427, P < 1 × 10−8]. In addition, meta-analysis revealed an association between the C allele of the MIF −173 C/G polymorphism and JIA in all subjects (OR 1.482, 95% CI 1.202–1.828, P = 2.3 × 10−4).

Conclusions

This meta-analysis confirms that the PTPN22 1858 C/T polymorphism is associated with JIA susceptibility in Europeans and shows that the MIF −173 C/G polymorphism may be associated with susceptibility to JIA.

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Acknowledgments

This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).

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None.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea

    Young Ho Lee & Gwan Gyu Song

  2. Hanyang University Medical Center, Seoul, Korea

    Sang-Cheol Bae

Authors
  1. Young Ho Lee
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  2. Sang-Cheol Bae
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  3. Gwan Gyu Song
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Correspondence to Young Ho Lee.

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Responsible Editor: Andras Falus.

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Lee, Y.H., Bae, SC. & Song, G.G. The association between the functional PTPN22 1858 C/T and MIF −173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis. Inflamm. Res. 61, 411–415 (2012). https://doi.org/10.1007/s00011-012-0447-5

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  • DOI: https://doi.org/10.1007/s00011-012-0447-5

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