Abstract
Forty-three goitrous patients (grade II and III, WHO classification), living in areas of chronic iodine deficiency, were treated with an injection of iodized oil (470 mg iodine). Serial measurements of serum thyroid hormone levels after the therapy revealed increasing concentrations of both hormones, with a significantly lower serum T3/T4 ratio, and progressively significantly lower serum TSH mean values. Serum Tg mean value, initially elevated (58 ± 9 ng/ml), decreased after 6 months and returned to the normal range at 36 months of therapy. In none of the examined patients (except for one subject with positive autoantibodies before therapy), it was observed the surge of positive anti- thyroglobulin or anti-microsomal autoantibodies after the iodized oil. We conclude that iodized oil therapy does not induce an abnormal autoimmune reaction in endemic goiter patients.
Similar content being viewed by others
References
Medeiros-Neto G.A., Maciel R.M.B., Halpern A. Iodine deficiency disorders and congenital hypothyroidism. Aché, São Paulo, 1986.
Hetzel B.S., Potter B.J. Iodine deficiency and the role of thyroid hormones. In: Dreosti I.E., Smith R.M. (Eds.), Brain Development, Neurobiology of the Trace Elements. Humana Press, New Jersey, 1983, p. 45.
Obregon M.J., Santisteban P., Rodriguez-Pena A., Pascual A., Cartagena P., Ruiz-Marcos A., Lamas L., Escobar del Rey F., Morreale de Escobar G. Cerebral hypothyroidism in rats with adult-onset iodine deficiency. Endocrinology 115: 614, 1984.
Potter R.J., Mano M.T., Belling G.B., Martin D.M., Cragg B.G., Chavadij J., Hetzel B.S. Restoration of brain growth in fetal sheep after iodized oil administration to pregnant iodine-deficient ewes. J. Neurol. Sci. 66: 15, 1984.
Kochupillai N., Godbole M.M., Pandav C.S., Ahuja M.M.S. Iodine deficiency and neonatal hypothyroidism in India. In: Ramalingaswami V., (Ed.), Iodine Nutrition, Thyroxine and Brain Development. Tata-McGraw Thel, New Delhi, 1985.
Vanderpas J., Bourdoux P., Lagasse R., Riviera M., Dramarx M., Lody P., Nelson G., Delange F., Ermans A.M., Thilly C.H. Endemic infantile hypothyroidism in severe endemic goitre area of Central Africa. Clin. Endocrinol. (Oxf.) 20: 327, 1984.
Hetzel B.S. Iodine deficiency disorders (IDD) and their eradication. Lancet 2: 1126, 1983.
Maberly G.F., Corcoran J.M., Eastman C.J. The effect of iodized oil on goitre size, thyroid function and the development of the Jod-Basedow phenomenon. Clin. Endocrinol. (Oxf.) 17: 253, 1982.
Boukis M.A., Koutras D.A., Souvatzoglou A., Evangelopoulou A., Vrontakis M., Moulopoulos S.M. Thyroid hormone and immunological studies in endemic goiter. J. Clin. Endocrinol. Metab. 57: 856, 1983.
Eltom M., Karlsson F.A., Kamal A.M., Bostrom H., Dahlberg R.A. The effectiveness of oral iodized oil in the treatment and prophylaxis of endemic goiter. J. Clin. Endocrinol. Metab. 61: 1112, 1985.
Medeiros-Neto G.A. Laboratory evaluation in iodine deficiency disorders. Arq. Bras. Endocrinol. Metabol. 28: 100, 1984.
Weaver D.K., Nishiyama R.N., Burton W.D., Batsakis J.G. Surgical thyroid disease: a survery before and after iodine prophylaxis. Arch. Surg. 92: 796, 1966.
Inoue M., Taketami N., Sato T., Nakayima H. High incidence of chronic lymphocytic thyroiditis in apparently healthy schoolchildren: epidemiological and clinical study. Endocrinol. Jpn. 22: 483, 1975.
Hall R., Turner-Warwick M., Doniach D. Autoantibodies in iodine goitre and asthma. Clin. Exp. Immunol. 1: 285, 1966.
Harach H.R., Escalante D.A., Onativia A., Lederer-Outes J., Saravia-Day E., Williams E.D. Thyroid carcinoma and thyroiditis in an endemic goitre region before and after iodine prophylaxis. Acta Endocrinol. (Kbh.) 108: 55, 1985.
Follis R.H. Further observations on thyroiditis and colloid accumulation in hyperplastic thyroid glands of hamsters receiving excess iodine. Lab. Invest. 13: 1590, 1964.
Evans T.C., Beierwalters W.H., Nishiyama R.H. Experimental canine Hashimoto’s thyroiditis. Endocrinology 84: 641, 1969.
Bagchi N., Brown T.R., Urdanivia E. Induction of autoimmune thyroiditis in chickens by dietary iodine. Science 230: 325, 1985.
Lima N., Knobel M., Medeiros-Neto G.A. Long term effect of iodized oil on serum thyroglobulin levels in endemic goitre patients. Clin. Endocrinol. (Oxf.) 24: 635, 1986
Refetoff S., Lever E.G. The value of serum thyroglobulin measurement in clinical practice. JAMA 250: 2353, 1983.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Knobel, M., Medeiros-Neto, G. Iodized oil treatment for endemic goiter does not induce the surge of positive serum concentrations of anti-thyroglobulin or anti-microsomal autoantibodies. J Endocrinol Invest 9, 321–324 (1986). https://doi.org/10.1007/BF03346935
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03346935