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Resveratrol-type oligostilbenes from Iris clarkei antagonize 20-hydroxyecdysone action in the Drosophila melanogaster BII cell line

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Abstract.

Bioassay-guided high-performance liquid chromatography analysis of a MeOH extract of Iris clarkei seeds yielded the resveratrol-type oligomeric stilbenes, ampelopsin B and α-viniferin, which antagonize the action of 20-hydroxyecdysone; with a 20-hydroxyecdysone concentration of 50 nM, the ED50 values were 33 μM and 10 μM, respectively. The structures of these compounds were determined by spectroscopic analysis, notably ultraviolet, liquid secondary ion mass spectrometry and modern one- and two-dimensional nuclear magnetic resonance techniques.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Exeter, Hatherly Laboratories, Prince of Wales Road, Exeter EX4 4PS (UK), e-mail: l.n.dinan@exeter.ac.uk, , , , , , UA

    K. Keckeis, S. D. Sarker**  & L. Dinan*

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  1. K. Keckeis
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  2. S. D. Sarker**
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  3. L. Dinan*
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Received 4 November 1999; accepted 13 December 1999

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Keckeis, K., Sarker** , S. & Dinan*, L. Resveratrol-type oligostilbenes from Iris clarkei antagonize 20-hydroxyecdysone action in the Drosophila melanogaster BII cell line . CMLS, Cell. Mol. Life Sci. 57, 333–336 (2000). https://doi.org/10.1007/PL00000694

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  • DOI: https://doi.org/10.1007/PL00000694

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