Abstract
In this formulation study, biocompatible non steroidal anti-inflammatory (NSAIDs)-loaded nanoparticles were designed as models to be further integrated in a prosthesis surface functionalization. A modified spontaneous emulsion-solvent diffusion methodology was used to produce drug-loaded PLGA nanoparticles without any purification or solvent evaporation requirements. Formulation parameters, such as lactide/glycolide ratio, polymer concentration, solvent/non solvent ratio and non solvent phase, as well as the non ionic tensioactive P188 co-precipitation composition were systematically explored. The optimized formulation (mean size: 145 nm, surface charge: −13 mV) was employed to encapsulate various amounts of NSAIDs in a simple and scalable manner. The drug release was characterized in vitro by a complete release for 48 h. These results encourage upcoming preliminary steps for in vivo experiments of prosthesis surface functionalization.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
A. Kumari, S. Kumar Yadav and S. C. Yadav, Colloids Surf. B 75, 1 (2010). doi:10.1016/j.colsurfb.2009.09.001
V. Dahl, J. C. Raede, S. Drosdal, O. Wathne and J. Brynildsrud, Acta Anaesthesiol. Scand. 39, 323 (1995). doi:10.1111/j.1399-6576.1995.tb04070.x
M. Fransen, Control. Clin. Trials 25, 223 (2004). doi:10.1016/j.cct.2003.11.008
C. L. Romano, D. Duci, D. Romano, M. Mazza and E. Meani, The Journal of Arthroplasty 19, 14 (2004). doi:10.1016/S0883-5403(03)00279-1
M. Fransen, C. Anderson, J. Douglas, S. MacMahon, B. Neal, R. Norton, M. Woodward, I. D. Cameron, R. Crawford, S. K. Lo, G. Tregonning and M. Windolf, BMJ. 333, 519 (2006). doi:10.1136/bmj.38925.471146.4F
J. P. Cella, E. A. Salvati and T. P. Sculco, The Journal of Arthroplasty 3, 229 (1988).
C. E. Mora-Huertas, H. Fessi and A. Elaissari, Int. J. Pharm. 385, 113 (2010). doi:10.1016/j.ijpharm.2009.10.018
T. Niwa, H. Takeuchi, T. Hino, N. Kunou and Y. Kawashima, J. Controlled Release 25, 89 (1993) doi:10.1016/0168-3659(93)90097-O
P. J. Weller, “Handbook of Pharmaceutical Excipients 5th edition”, London: Pharmaceutical Press, 2006.
N. Csaba, P. Caamaño, A. Sánchez, F. Dominguez and M. J. Alonso, Biomacromolecules 6, 271 (2005). doi:10.1021/bm049577p
O. Albayrak, O. El-Atwani and S. Altintas, Surf. Coat. Technol. 202, 2482 (2008). doi:10.1016/j.surfcoat.2007.09.031
K. Y Win and S. S. Feng, Biomaterials 26, 2713 (2005). doi:10.1016/j.biomaterials.2004.07.050
H. Gao, Y. N. Wang, Y. G. Fan and J. B. Ma, J. Biomed. Mater. Res. Part A 80, 111 (2007). doi:10.1002/jbm.a.30861
T. Riley, S. Stolnik, C. R. Heald, C. D. Xiong, M. C. Garnett, L. Illum and S. S. Davis, Langmuir 17, 3168 (2001). doi:10.1021/la001226i
G. Mittal, D. K. Sahana, V. Bhardwaj and M. N. V. Ravi Kumar, J. Controlled Release 119, 77 (2007). doi:10.1016/j.jconrel.2007.01.016
D. Quintanar-Guerrero, E. Allemann, H. Fessi and E. Doelker, Int. J. Pharm. 188, 155 (1999). doi:10.1016/S0378-5173(99)00216-1
T. Jung, A. Breitenbach and T. Kissell, J. Controlled Release 67, 157 (2000). doi:10.1016/S0168-659(00)002017
J. Cheng, B. A. Teply, I. Sherifi, J. Sung, G. Luther, F. X. 3Langer and O. C. Farokhzad, Biomaterials 28, 869 (2007). doi:10.1016/j.biomaterials.2006.09.047
D. Quintanar-Guerrero, E. Allemann and E. Doelker, Colloid Polym. Sci. 275, 640 (1997). doi:10.1007/s003960050130
N. Anton, J. P. Benoit and P. Saulnier, J. Controlled Release 128, 185 (2008). doi:10.1016/j.jconrel.2008.02.007
A. Aumelas, A. Serrero, A. Durand, E. Dellacherie and M. Leonard, Colloids Surf. B 59, 74 (2007). doi:10.1016/j.colsurfb.2007.04.021
B. K. Kim, D. Kim, S. H. Cho and S. H. Yuk, J. Microencapsulation 21, 697 (2004). doi:10.1080/02652040400000520
S. W. Choi, H. Y. Kwon, W. S. Kim and J. H. Kim, Colloids Surf. A 201, 283 (2002). doi:10.1016/S09277757(01)01042-1
F. Gu, L. Zhang, B. A. Teply, N. Mann, A. Wang, A. F. Radovic-Moreno, R. Langer and O. C. Farokhzad, Proc. Natl. Acad. Sci. U. S. A. 105, 2586 (2008). doi:10.1073/pnas.0711714105
C. Passirani, G. Barratt, J. P. Devissaguet and D. Labarre, Pharm. Res. 15, 1046 (1998). doi:10.1023/A:1011930127562
N. Csaba, L. González, A. Sánchez and M. J. Alonso, J. Biomater. Sci. Polym. Ed. 1137 (2004). doi:10.1163/1568562041753098
B. Jiang, L. Hu, C. Gao and J. Shen, Int. J. Pharm. 304, 220 (2005). doi:10.1016/j.ijpharm.2005.08.008
M. A. Casadei, F. Cerreto, S. Cesa, M. Giannuzzo, M. Feeney, C. Marianecci and P. Paolicelli, Int. J. Pharm. 325, 140 (2006). doi:10.1016/j.ijpharm.2006.06.012
M. Feng, P. Li, J. Biomed. Mater. Res. Part A 80, 184 (2007). doi:10.1002/jbm.a.30882
A. Sheikh Hasan, M. Socha, A. Lamprecht, F. E. Ghazouani, A. Sapin, M. Hoffman, P. Maincent and N. Ubrich, Int. J. Pharm. 344, 53 (2007). doi:10.1016/j.ijpharm.2007.05.066
F. Alexis, Polym. Int. 54, 36 (2005). doi:10.1002/pi.1697
N. Faisant, J. Siepmann and J. P. Benoit, Eur. J. Pharm. Sci. 15, 355 (2002). doi:10.1016/S0928-0987(02)00023-4
J. Siepmann and F. Siepmann, Int. J. Pharm. 364, 328 (2008). doi:10.1016/j.ijpharm.2008.09.004
B. S. Zolnik, P. E. Leary and D. J. Burgess, J. Controlled Release 112, 293 (2006). doi:10.1016/j.jconrel.2006.02.015
E. Vega, F. Gamisans, M. L. Garcia, A. Chauvet, F. Lacoulonche and M. A. Egea, J. Pharm. Sci. 97, 5306 (2008). doi:10.1002/jps.21383
Y. Javadzadeh, F. Ahadi, S. Davaran, G. Mohammadi, A. Sabzevari and K. Adibkia, Colloids Surf. B 81, 498 (2010). doi:10.1016/j.colsurfb.2010.07.047
D. Klose, F. Siepmann, K. Elkharraz and J. Siepmann, Int. J. Pharm. 354, 95 (2008). doi:10.1016/j.ijpharm.2007.10.030
W. J. Cho, J. H. Kim, S. H. Oh, H. H. Nam, J. M. Kim and J. H. Lee, J. Biomed. Mater. Res., Part A 91, 400 (2009) doi:10.1002/jbm.a.32264
R. E. Eliaz and J. Kost, J. Biomed. Mater. Res. 50, 388 (2000).
A. Aubert-Pouëssel, M. C. Venier-Julienne, P. Saulnier, M. Sergent and J. P. Benoît, Pharm. Res. 21, 2384 (2004). doi:10.1007/s11095-004-7693-3
D. Allhenn and A. Lamprecht, Pharm. Res. (2010). doi:10.1007/s11095-010-0304-6
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Roullin, V.G., Callewaert, M., Molinari, M. et al. Optimised NSAIDs-loaded Biocompatible Nanoparticles. Nano-Micro Lett. 2, 247–255 (2010). https://doi.org/10.1007/BF03353851
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03353851