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Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism

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Abstract

Serial measurements of body mass index (BMI), serum concentrations of testosterone (T), estradiol (E) and leptin (L) were performed before and after gonadotropin (Gn) therapy in an 18-year-old male subject (BMI 25.4 kg/m2) with idiopathic hypothalamic hypogonadism (IHH). We also measured the BMI and serum concentrations of L in 99 age-matched healthy subjects. Serum L correlated significantly with BMI in control subjects (r=0.84, p<0.0001). Baseline serum concentrations of L in our case were markedly high and both T and E were very low, but Gn therapy resulted in a gradual decrease in L and improvement in T and E, finally reaching the control levels of BMI-matched subjects. Our results demonstrate that T is a powerful negative modulator of serum L independent of BMI in conditions associated with low T levels, such as IHH.

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Authors and Affiliations

  1. Health and Medical Center, Okayama University, Tsushima-Naka 2-1-1, 700-8530, Okayama, Japan

    T. Ogura MD, K. Tobe, A. Imai, C. Tsukamoto, Y. Iwasaki & K. Matsuura

  2. Faculty of Education, Okayama University, Japan

    Y. Mimura

  3. Department of Medicine Ill, Okayama University, Japan

    F. Otsuka & T. Yamauchi

Authors
  1. T. Ogura MD
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  2. K. Tobe
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  3. Y. Mimura
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  4. F. Otsuka
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  5. T. Yamauchi
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  6. A. Imai
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  7. C. Tsukamoto
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  8. Y. Iwasaki
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  9. K. Matsuura
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Correspondence to T. Ogura MD.

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Ogura, T., Tobe, K., Mimura, Y. et al. Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism. J Endocrinol Invest 23, 246–250 (2000). https://doi.org/10.1007/BF03343716

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  • DOI: https://doi.org/10.1007/BF03343716

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