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Retinoic acid isomers protect hippocampal neurons from amyloid-β induced neurodegeneration

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Abstract

Attenuating amyloid-β mediated neurodegeneration is of major therapeutic consideration in the potential treatment of Alzheimer disease. Previously, we found that a high dietary consumption of retinoic acid was associated with a reduced incidence of Alzheimer disease. Therefore, in this study, we investigated whether amyloid-β mediated cell death in primary hippocampal neurons could be prevented by retinoic acid isomers. Our results suggest that retinoic acid isomers, including all-trans retinoic acid, 9-cis retinoic acid, and 13-cis retinoic acid, may play an important role in protecting neurons from amyloid-β-induced cell death. Retinoic acid may therefore afford a novel therapeutic mechanism for the treatment and prevention of Alzheimer disease.

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Authors and Affiliations

  1. Akdeniz University, Faculty of Medicine, Department of Biochemistry, Dumlupinar Boulevard, 07070, Arapsuyu-Antalya, Turkey

    Mehmet Sahin & Yakup Alicigüzel

  2. Akdeniz University, Faculty of Medicine, Department of Medical Biology and Genetics, Dumlupinar Boulevard, 07070, Arapsuyu-Antalya, Turkey

    Sibel Berker Karaüzüm

  3. Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA

    George Perry & Mark A. Smith

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  1. Mehmet Sahin
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  2. Sibel Berker Karaüzüm
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  3. George Perry
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  4. Mark A. Smith
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  5. Yakup Alicigüzel
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Correspondence to Mark A. Smith or Yakup Alicigüzel.

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Sahin, M., Karaüzüm, S.B., Perry, G. et al. Retinoic acid isomers protect hippocampal neurons from amyloid-β induced neurodegeneration. neurotox res 7, 243–250 (2005). https://doi.org/10.1007/BF03036453

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  • DOI: https://doi.org/10.1007/BF03036453

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