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Myocardial single-photon emission computed tomographic imaging with technetium 99m tetrofosmin: Stress-rest imaging with same-day and separate-day rest imaging

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Technetium 99m tetrofosmin is a new ethylene diphosphine ligand for myocardial perfusion imaging and has unique properties. We have compared stress-rest single-photon emission computed tomographic (SPECT) imaging with99mTc tetrofosmin with same-day and separate-day rest imaging to detect myocardial perfusion defects.

Methods and Results

Myocardial SPECT imaging was performed in 22 patients with coronary artery disease who had undergone planar thallium 201 imaging and coronary angiography. Single-day (stress-rest) and separate-day rest99mTc tetrofosmin SPECT protocols were compared in the same patient. Images were assessed by a blinded panel to identify myocardial infarction, ischemia, or normal scans. Overall sensitivity for identification of patients with coronary artery disease was 86% (19/22) by both same-day stress-rest and separate-day rest protocols with99mTc tetrofosmin (p=NS). Of a total of 396 segments studied, 107 abnormal segments were identified at exercise and 76 and 81 at the same-day and separate-day rest tests, respectively (p=NS). Same-day stress-rest and separate-day rest99mTc tetrofosmin SPECT protocols were also useful for detecting individual coronary stenosis with a greater than 50% lesion: 80% of the left anterior descending, 93% of the right coronary, and 75% of the left circumflex coronary arteries were detected.

Conclusion

Excellent images were obtained with99mTc tetrofosmin during both stress and rest.99mTc tetrofosmin imaging with the same-day stress-rest and separate-day rest imaging protocols have similar diagnostic sensitivities for detection of coronary heart disease.

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Authors and Affiliations

  1. Northwick Park Hospital and Clinical Research Centre, Harrow, UK

    Bangalore Sridhara, Heinz Sochor, Pierre Rigo, Simon Braat, Roland Itti, David Martinez-Duncker, Paul Cload & Avijit Lahiri

  2. University Hospital, Vienna, Austria

    Bangalore Sridhara, Heinz Sochor, Pierre Rigo, Simon Braat, Roland Itti, David Martinez-Duncker, Paul Cload & Avijit Lahiri

  3. Centre Hospitalier Universiat, Liege, Belgium

    Bangalore Sridhara, Heinz Sochor, Pierre Rigo, Simon Braat, Roland Itti, David Martinez-Duncker, Paul Cload & Avijit Lahiri

  4. Academisch Ziekenhuis, Maastricht, The Netherlands

    Bangalore Sridhara, Heinz Sochor, Pierre Rigo, Simon Braat, Roland Itti, David Martinez-Duncker, Paul Cload & Avijit Lahiri

  5. Hospital Neuro-Cardiologique, Lyon, France

    Bangalore Sridhara, Heinz Sochor, Pierre Rigo, Simon Braat, Roland Itti, David Martinez-Duncker, Paul Cload & Avijit Lahiri

  6. Amersham International plc, Amersham, UK

    Bangalore Sridhara, Heinz Sochor, Pierre Rigo, Simon Braat, Roland Itti, David Martinez-Duncker, Paul Cload & Avijit Lahiri

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  1. Bangalore Sridhara
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  2. Heinz Sochor
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  3. Pierre Rigo
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  4. Simon Braat
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  5. Roland Itti
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  7. Paul Cload
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  8. Avijit Lahiri
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Sridhara, B., Sochor, H., Rigo, P. et al. Myocardial single-photon emission computed tomographic imaging with technetium 99m tetrofosmin: Stress-rest imaging with same-day and separate-day rest imaging. J Nucl Cardiol 1, 138–143 (1994). https://doi.org/10.1007/BF02984085

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  • DOI: https://doi.org/10.1007/BF02984085

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