Abstract
Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activityin vivo. In this study, new anti-inflammatory formulation containingS. deltoides extract as a major ingredient was prepared andin vivo activity was evaluated. The plausible action mechanism was also investigated. The new formulation (SAG) contains 1 part ofS. deltoides extract, 0.9 part ofAngelica gigas extract and 0.9 part of glucosamine sulfate (w/w). SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation. SAG showed 44.1% inhibition of AA-induced ear edema at an oral dose of, 50 mg/kg. In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7-day model of multiple treatment of TPA (38.1% inhibition at 200 mg/kg/day). Furthermore, SAG (50–800 mg/kg/day) as well asS. deltoides extract (285 mg/kg/day) significantly inhibited prostaglandin E2 production from the skin lesion of the animals of 7-day model. These results were well correlated within vitro finding that SAG as well asS. deltoides extract reduced cyclooxygenase (COX)-1- and COX-2-induced prostanoid production, measured in mouse bone marrow-derived mast cells. There-fore, these results suggest that SAG possesses anti-inflammatory activityin vivo against acute as well as chronic inflammatory animal models at least in part by inhibition of prostaglandin production through COX-1/COX-2 inhibition. And COX inhibition of SAG is possibly contributed byS. deltoides extract among the ingredients. Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical.
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Choi, Y.H., Son, K.H., Chang, H.W. et al. New anti-inflammatory formulation containingSynurus deltoides extract. Arch Pharm Res 28, 848–853 (2005). https://doi.org/10.1007/BF02977352
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DOI: https://doi.org/10.1007/BF02977352