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Antiviral triterpenes fromPrunella vulgaris

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Abstract

Two triterpenes 1 and 2 with antiviral activity againstHerpes simplex virus type 1in vitro were isolated fromPrunella vulgaris. Each compound caused a significant reduction in viral cytopathic effect whenvero cells were exposed to them for 72 hours after viral challenge. They were identified asbetulinic acid(1) and 2α, 3α-dihydroxyurs-12-en-28-oic acid(2) on the basis of their spectroscopic properties. The antiviral activity of them was estimated as EC50=30 μg/ml(1) and 8 μg/ml(2), respectively by plaque reduction assay.

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Authors and Affiliations

  1. Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea

    Shi Yong Ryu, Chong-Kyo Lee, Chong Ock Lee, Hae Soo Kim & Ok Pyo Zee

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  1. Shi Yong Ryu
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  2. Chong-Kyo Lee
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  3. Chong Ock Lee
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  4. Hae Soo Kim
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  5. Ok Pyo Zee
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Ryu, S.Y., Lee, CK., Lee, C.O. et al. Antiviral triterpenes fromPrunella vulgaris . Arch. Pharm. Res. 15, 242–245 (1992). https://doi.org/10.1007/BF02974063

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  • DOI: https://doi.org/10.1007/BF02974063

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