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Cystic hypersecretory duct carcinoma of the breast: A case report describing the cytologic features

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Abstract

We report the clinical, cytological and pathological features of so-called cystic hypersecretory duct carcinoma occurring in a 60-year-old Japanese woman. The tumor manifested a multicystic mass ultrasonographically, and aspiration biopsy cytology revealed atypical ductal epithelial cells with vacuolar cytoplasm. A modified radical mastectomy was performed. Histologically, the lesion was characterized by many dilated ducts containing eosinophilic secretions, which resembled thyroid colloid. The ducts were lined by an intraductal micropapillary carcinoma with hobnail-shaped cells, and were positive for lactalbumin immunohistochemically. Additionally, a so-called cystic hypersecretory hyperplasia was seen in the surrounding breast parenchyma. Although a direct transition from the hyperplasia to the carcinoma was not proved, a close relationship between the two lesions was suggested.

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Abbreviations

CHC:

Cystic hypersecretory duct carcinoma

CHH:

Cystic hypersecretory hyperplasia

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Authors and Affiliations

  1. Department of Pathology, Kawasaki Hospital, Kawasaki Medical School, 2-1-80 Nakasange, 700, Okayama, Japan

    Takuya Moriya, Jishu Ito & Hirohisa Takasuga

  2. Kunitomi Clinic, Japan

    Kunjyasu Okazaki

Authors
  1. Takuya Moriya
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  2. Jishu Ito
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  3. Hirohisa Takasuga
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  4. Kunjyasu Okazaki
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Moriya, T., Ito, J., Takasuga, H. et al. Cystic hypersecretory duct carcinoma of the breast: A case report describing the cytologic features. Breast Cancer 3, 131–134 (1996). https://doi.org/10.1007/BF02966974

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  • DOI: https://doi.org/10.1007/BF02966974

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