Summary
Argyrophilia and argentaffinity, as basic properties of APUD cells, were investigated in 50 normal and hyperplastic prostates, which included both autopsy and surgical specimens from patients of various ages. Normal prostates (including glands from 3 foetuses) had 62% of argyrophil-positive granules in the glandular epithelia, while only 44% of the hyperplastic glands were positive. Argentaffin-positive cells were found in 12% of the surgical hyperplastic cases. Both argyrophil and argentaffin cells were distributed in zones, often in lobule-like shapes, lying along the basal membrane. On the basis of these findings, there is a discussion on the possible roles played by the so-called APUD cells in hyperplastic and neoplastic growths of the prostate, such as carcinoid tumours (apudomas) or endocrine-associated syndromes in the course of prostatic cancer.
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Aoyama H., Yoshida K., Kondo T., Hijioka T., Okajima E.: Primary carcinoid tumor of the urinary bladder (report of a case)—Jap. J. Urol.69, 124, 1978.
Azzopardi J. G., Evans D. J.: Argentaffin cells in prostatic carcinoma: differentiation from lipofuscin and melanin in prostatic epithelium—J. Path.104, 247, 1971.
Berry N. E., Reese L.: Malignant melanoma which had its first clinical manifestation in the prostage gland—J. Urol. (Baltimore)69, 286, 1953.
Block N. L., Weber D., Schinella R.: Blue nevi and other melanotic lesions of the prostate— J. Urol. (Baltimore)107, 85, 1975.
Corrado F., Casanova S., Vignoli G.: Cellule endocrine nell'uretta maschile. Studio al microscopio elettronico—Urologia (Treviso)41, 541, 1974.
Dixon J. S., Gosling J. A., Ramsdale D. R.: Urethral chromaffin cells. A light and electron microscopic study—Z. Zellforsch.138, 397, 1973.
Feyrter F.: Über diffuse endokrine epitheliale Organe—J. A. Barth, Leipzig, 1938.
Godwin J. D.: Carcinoid tumors. An analysis of 2837 cases—Cancer36, 560, 1975.
Goldmann R. L.: Melanogenic epithelium in the prostate gland—Amer. J. clin. Path.49, 75, 1968.
Hakanson R., Larsson L. I., Sjöberg N. O., Sundler F.: Amine producing endocrine-like cells in the epithelium of urethra and prostate of the guinea pig. A chemical, fluorescence, histochemical, electron microscopic study—Histochemistry38, 259, 1974.
Hall T. C.: Symptomatic hypokalemic alkalosis in hyperadrenocorticism secondary to carcinoma of the prostate—Cancer21, 190, 1968.
Hernandes F. J., Reid J. D.: Mixed carcinoid and mucus secreting intestinal tumors—Arch. Path.88, 489, 1969.
Kano K., Sato S.: Observation of endocrine cells in prostatic adenoma. An electron microscopic finding—Urologia (Treviso)45, 313, 1978.
Kazzaz B. A.: Argentaffin and argyrophil cells in the prostate—J. Path.112, 189, 1974.
Nigogosyan G., De la Pava S., Pickren J. W., Woodruff M. W.: Blue nevus of the prostate gland—Cancer16, 1097, 1963.
Pearse A. G. E.: Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitonin—Proc. roy. Soc. B170, 71, 1968.
Pearse A. G. E.: Neurocristopathy, neuroendocrine pathology and the APUD concept— Z. Krebsforsch.84, 1, 1975.
Ramsdale D. R.: Further observations on urethral chromaffin cells. An electron microscopic study—Cell Tiss. Res.148, 499, 1974.
Sellwood R. A., Spencer J., Azzopardi J. G., Wapnik S., Welbourne R. B., Kulatilake A. E.: Inappropriate secretion of ADH by carcinoma of the prostate—Brit. J. Surg.56, 933, 1969.
Szijj T., Csapo Z., Lasslo F. A., Kovacs K.: Medullary carcinoma of the thyroid associated with hypercorticism—Cancer24, 167, 1969.
Welbourne R. B.: Current status of the apudomas—Ann. Surg.185, 1, 1977.
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Pollice, L., Resta, L. & Simone, G. Apud cells in normal and hyperplastic prostates. La Ricerca Clin. Lab. 9, 273–278 (1979). https://doi.org/10.1007/BF02932179
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DOI: https://doi.org/10.1007/BF02932179