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Idiopathic giant-cell granuloma of the pituitary with unusual clinical and histological features

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Abstract

A surgically treated idiopathic giant-cell granuloma of the pituitary in a 48-year-old man is described. Relative to previously reported cases, this case was unusual both clinically and histologically. Diabetes insipidus was the initial, and a prominent clinical, manifestation. Histological studies showed caseating granuloma or fibrosis in addition to a typical giant-cell granuloma. This is the first published documentation of the association of caseous necrosis in a patient diagnosed as having idiopathic giant-cell granuloma of the pituitary.Endocr Pathol 4:169–173, 1993.

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References

  1. Albini CH, MacGillivray MH, Fisher JE, Voorhess ML, Klein DM. Triad of hypopituitarism, granulomatous hypophysitis, and ruptured Rathke’s cleft cyst. Neurosurgery 22:133–136, 1988.

    Article  CAS  Google Scholar 

  2. Alonso JF, Ortiz F, Perez M. Hipofistis granulomatosa de probable etiologia autoimmune. Un caso diagonisticado post mortem. Med Clin (Bar) 95:100–102, 1990.

    Google Scholar 

  3. Bachour E, Perrin G, Ciriano P, Trouillas J, Sassolas G, Tommasi M, Goutelle A. Les granulomes idiopathiques a cellules géantes de l’hypophyse. Neurochirurgie 37:253–257, 1991.

    CAS  PubMed  Google Scholar 

  4. DelPozo JM, Roda JE, Montoya JG, Lglesias JR, Hurtado A. Intrasellar granuloma. J Neurosurg 53:717–719, 1980.

    Article  CAS  Google Scholar 

  5. Hassoun P, Anayssi E, Salti I. A case of granulomatous hypophysitis with hypopituitarism and minimal pituitary enlargement. J Neurol Neurosurg Psychiatry 49:949–951, 1985.

    Article  Google Scholar 

  6. Hoick S, Laursen H. Prolactinoma coexistent with granulomatous hypophysitis. Acta Neuropathol 61:253–257, 1983.

    Article  Google Scholar 

  7. McKeel DW Jr. Common histopathologic and ultrastructural features in granulomatous and lymphoid adenohypophysitis (abstract). Fed Proc 31:821, 1983.

    Google Scholar 

  8. Miyamoto M, Sugawa H, Mori T, Hashimoto N, Imura H. A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis. Endocrinol Jpn 35:607–616, 1988.

    Article  CAS  Google Scholar 

  9. Oeckler RCT, Bise K. Non-specific granulomas of the pituitary: report of six cases treated surgically. Neurosurg Rev 14:185–190, 1991.

    Article  CAS  Google Scholar 

  10. Post KD, McCormick PC, Bello JA. Differential diagnosis of pituitary tumors. Endocrinol Metab Clin North Am 16:609–645, 1987.

    Article  CAS  Google Scholar 

  11. Rickards AG, Harvey PW. Giant-cell granuloma and the other pituitary granulomata. QJ Med 23:425–439, 1954.

    CAS  Google Scholar 

  12. Scanarini M, D’Avella D, Rotilio A, Kitromilis N, Mingrino S. Giant cell granulomatous hypophysitis: a distinct clinocopathological entity, J Neurosurg 71:681–686, 1989.

    Article  CAS  Google Scholar 

  13. Scheithauer BW. The hypothalamus and neurohypophysis. In: Kalman K, Asa SL, eds. Functional endocrine pathology. Vol 1. Boston: Blackwell Scientific, 1991:170–240.

    Google Scholar 

  14. Scully RE, Mark EJ, McNeely BU. Case records of the Massachusetts General Hospi- tal. Case 5-1985. N Engl J Med 312:297–305, 1985.

    Article  Google Scholar 

  15. Siqueira E, Tsung JS, Alkawi MZ, Woodhause N. Case report: idiopathic giant cell granuloma of the hypothesis: an unusual cause of panhypopituitarism. Surg Neurol 32:68–71, 1989.

    Article  CAS  Google Scholar 

  16. Subbuswamy SG, Mansukhani SH, Gadgil RK. Giant cell granuloma of the pituitary. Indian J Med Sci 21:816–818, 1967.

    CAS  PubMed  Google Scholar 

  17. Sundarasivarao D. Giant-cell granuloma of the pituitary J Indian Med Assoc 42:531–533, 1964.

    CAS  PubMed  Google Scholar 

  18. Taylon C, Duff TA. Giant cell granuloma involving the pituitary gland. J Neurosurg 52:584–587, 1980.

    Article  CAS  Google Scholar 

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Yamada, S., Sawano, S., Aiba, T. et al. Idiopathic giant-cell granuloma of the pituitary with unusual clinical and histological features. Endocr Pathol 4, 169–173 (1993). https://doi.org/10.1007/BF02915307

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