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Syndecan-1 - A new piece in B-cell puzzle

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Pathology & Oncology Research

Abstract

Syndecans are transmembrane proteoglycans, with core proteins mainly decorated with heparan sulfate chains. Syndecan-1 is expressed in a tissue-, cell-and differentiation-specific manner. Its extra-cellular domain can bind via HS chains to matrix elements, to growth factors (especially “heparin-binding” proteins) and to certain biological agents. The ectodomain released by proteolysis can also be functionally active. The cytoplasmic domain can take part in signaling processes as well as in modifying cell shape. In hematopoietic cells syndecan-1 is expressed in normal pre-B-cells and plasma cells, as well as in plasmocytoid and lymphoplasmocytoid malignancies. According to our study syndecan-1 is expressed in B-CLL cells both in tissue environment and in circulation.

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  1. 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üő;i út 26, H-1085, Budapest, Hungary

    László Kopper, Anna SebestyÉn, Mónika Gallai & Ilona Kovalszky

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  1. László Kopper
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Correspondence to László Kopper.

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This work has been supported by OTKA T107083 project (L. K.)

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Kopper, L., SebestyÉn, A., Gallai, M. et al. Syndecan-1 - A new piece in B-cell puzzle. Pathol. Oncol. Res. 3, 183–191 (1997). https://doi.org/10.1007/BF02899919

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