Skip to main content
Log in

Traditional anti-malarial medicine in Roraima, Brazil

Medicina traditional anti-malárica em Roraima, Brasil

  • Published:
Economic Botany Aims and scope Submit manuscript

Abstract

Malaria is probably the most serious health problem facing northern Amazonia, and isolated populations can benefit greatly from the knowledge of local resources which may effectively be used to control it. The results of an ethnobotanical survey of the plant species used in the treatment of malaria in the Brazilian State of Roraima are presented. Fieldwork was carried out amongst seven savanna-and forest-dwelling indigenous groups, and among the Luso-Brazilian population. Ninety-nine species, of 82 genera and 41 families, were identified as having been used for this purpose in the region. The results are discussed in the context of previously published information on anti-malarial plants of northern Latin America, which was analysed by a broad literature survey whose overall results are also presented here. Of the species collected in Roraima, only 24 appear previously to have been reported as anti-malarials, although 49% of the represented genera are known to be used in this way elsewhere. The plants are currently undergoing laboratory screening for anti-malarial activity and toxicity.

Resumen

A malaria é, provavelmente, o problema de saúde mais grave que afeta o norte da Amazônia, e as populaÇões isoladas podem se beneficiar muito com o conhecimento dos recursos naturals que servem para combatěla. Os resultados de um levantamento etnobotănico das espécies de plantas utilizadas no tratamento de malária no estado de Roraima (Brasil) são aqui apresentados. Trabalho de campo foi realizado com sete grupos indígenas da savana e da floresta, e com a populaÇão Luso-brasi-leira. Noventa e nove espécies, de 82 gěneros e 41 famílias, foram identificadas como sendo utilizadas para esta finalidade na região. Os resultados são discutidos no contexto das infor-maÇões já existentes sobre plantas anti-maláricas do norte da América Latina, as quais foram analizadas através de um amplo levantamento bibliográfico cujos resultados principals também são aqui apresentados. Entre as espécies coletadas em Roraima, somente 24 parecem ter sido previamente documentadas como anti-maláricas, porém 49% dos gěneros representados säo conhecidos como anti-máldricos em outras regiões. As plantas estão sendo atualmente testadas em laboratório para verificar a presenca de atividade anti-malárica e de toxicidade.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literature Cited

  • Abreu Matos, F. J. de. 1987. O formulário fitoter-ápico do Professor Dias de Rocha. ColeÇão ESAM Ano XX, Vol. 18.

  • —. 1989. Plantas medicinais. Guia de seleÇão e emprego de plantas medicinais do nordeste de Brasil Volume II. IOCE, Fortaleza.

    Google Scholar 

  • —. 1994. Farmácias vivas. EUFC, Fortaleza.

    Google Scholar 

  • Altshul, S.von R. 1973. Drugs and foods from little-known plants. Harvard University Press, Cambridge.

    Google Scholar 

  • —,and F. Lipp. 1982. New sources for drugs and foods from the New York Botanical Garden herbaria. Harvard University Press, Cambridge.

    Google Scholar 

  • Amorim, G. M., C. A. Flores, B. E. Gomes, A. D. Marques, and R. S. B. Cordeiro. 1988. Screening for antimalarial activity in the genusPotho-morphe. Journal of Ethnopharmacology 24(1): 101–106.

    Article  PubMed  CAS  Google Scholar 

  • Arévalo Valera, G. 1994. Las plantas medicinales y su beneficio en la salud Shipibo-Conibo. AIDESP, Lima.

    Google Scholar 

  • Ayensu, E. S. 1981. Medicinal plants of the West Indies. Reference Publications, Algonac, Michigan.

    Google Scholar 

  • Badam, L., R. P. Deolankar, S. R. Rojatkar, B. A. Nagsampgi, and U. V. Wagh. 1988. In vitro antimalarial activity of medicinal plants of India. Indian Journal of Medical Research 87(4):379–383.

    PubMed  CAS  Google Scholar 

  • Balée, W. L. 1994. Footprints of the forest. Ka’apor ethnobotany—the historical ecology of plant utilization by an Amazonian people. Columbia University Press, New York.

    Google Scholar 

  • Balick, M. J. 1994. Ethnobotany, drug development and biodiversity conservation—exploring the linkages. Pages 4–24in G. T. Prance, D. J. Chadwick, and J. Marsh, eds., Ethnobotany and the search for new drugs. Ciba Foundation Symposium 185. John Wiley & Sons, New York.

    Chapter  Google Scholar 

  • Becker, E. R. 1949. Report on the twenty-five drugs and three plant materials tested againstPlasmodium lophurae in the white Peking duck. Iowa State College Journal of Science 23:189.

    PubMed  CAS  Google Scholar 

  • Berg, M. E.van den, and M. H. L.da Silva. 1988. ContribuiÇão ao conhecimento da flora medicinal de Roraima. Acta Amazonica 18(1-2 Supl.):23–35.

    Google Scholar 

  • Blair, S., A. Correa, B. Madrigal, C. Zuluaga, and H. D. Franco. 1991. Plantas antimaláricas. Una revisión bibliográfica. Editorial Universidad de Antioquia.

  • Boggan, J., V. Funk, C. Kelloff, M. Hoff, G. Cremers, and C. Feuillet. 1992. Checklist of the plants of the Guianas. Biological Diversity of the Guianas Program, Smithsonian Institution, Washington.

    Google Scholar 

  • Bolin, B., B. R. Döös, J. Jagar, and R. A. Warrick. 1986. The greenhouse effect, climatic change and ecosystems. John Wiley, New York.

    Google Scholar 

  • Boom, B. M. 1987. Ethnobotany of the Chácobo Indians, Beni, Bolivia. Advances in Economic Botany 4:1–68.

    Google Scholar 

  • Brailowsky, R. 1982. Plantas medicinales de Puerto Rico. Sociología 498. Programa de Honor, Universidad Interamericana, Recinto de San Germán.

    Google Scholar 

  • Branch, L. C., and M. F. da Silva. 1983. Folk medicine of Alter do Cháo, Pará, Brazil. Acta Amazonica 13(5-6):737–797.

    Google Scholar 

  • Brandão, M. G. L., M. G. A. Botelho, and A. U. Krettli. 1985. Quimoterapia experimental anti-málarica com productos naturais: uma abordagem mais racional? Ciěncia e Cultura 37(7): 1152–1163.

    Google Scholar 

  • —,T. S. M. Grandi, E. M. M. Rocha, D. R. Sawyer, and A. U. Krettli. 1992. Survey of medicinal plants used as antimalarials in the Amazon. Journal of Ethnopharmacology 36:175–182.

    Article  PubMed  Google Scholar 

  • Bray, D. H., D. C. Warhurst, J. D. Connolly, M. J. O’Neill, and J. D. Phillipson. 1990. Plants as sources of antimalarial drugs. Part 7. Activity of some species of Meliaceae plants and their constituent limonoids. Phytotherapy Research 4(l):29–35.

    Article  CAS  Google Scholar 

  • Carvalho, L. H., M. G. L. Brandão, D. Santos-Filho, J. L. C. Lopes, and A. U. Krettli. 1991. Anti-malarial activity of crude extracts from Brazilian plants studied in vivo inPlasmodium berghei-in-fected mice and in vitro againstPlasmodium fal-ciparum in culture. Brasilian Journal of Medical & Biological Research 24(11): 1113–1123.

    CAS  Google Scholar 

  • Cavalcante, P. B. and P. Frikel. 1973. A farmaco-peia Tiriyó. MPEG, Belém.

    Google Scholar 

  • CCPY. 1992. Defense of the Yanomami—CCPY’s work program and budget for the period April 1992-March 1993. CCPY, São Paulo.

    Google Scholar 

  • Cox, P. A. 1994. The ethnobotanical approach to drug discovery: strengths and limitations. Pages 25–41in G. T. Prance, D. J. Chadwick and J. Marsh, eds., Ethnobotany and the search for new drugs. Ciba Foundation Symposium 185. John Wiley & Sons, New York.

    Chapter  Google Scholar 

  • Delascio Chitty, F. 1985. Algunas plantas usadas en la medicina empirica Venezolana. Direccion de In-vestigaciones Biologicas, INPARQUES, Caracas.

    Google Scholar 

  • Diocese de Roraima. 1994. 1° Caderneto com recei-tas de plantas medicinais. Diocese de Roraima, Boa Vista.

    Google Scholar 

  • Di Stasi, L. C, E. M. G. Santos, C. M. dos Santos, and C. A. Hiruma. 1989. Plantas medicinais na Amazônia. Editora UNESP, São Paulo.

    Google Scholar 

  • —,C. C. Hiruma, E. M. Guimaraes, and C. M. dos Santos. 1994. Medicinal plants popularly used in Brazilian Amazon. Fitoterapia 65(6):529–540.

    Google Scholar 

  • Dominguez, J. A. 1932. Malaria treatment withAs-pidosperma quebracho-bianco. Revista farmacéu-tica (Buenos Aires) 73:82.

    CAS  Google Scholar 

  • Duke, J. A., and R. Vasquez. 1994. Amazonian ethnobotanical dictionary. CRC Press, Boca Raton.

    Google Scholar 

  • Emperaire, L. 1983. La caatinga du sud-est du Piaui, Brésil. Étude Ethnobotanique. Éditions Recherche sur les Civilisations, Memoire No 21.

  • Estrella, E. 1995. Plantas medicinales Amazonicas: realidad e perspectivas. Tratado de Cooperacion Amazonica, Lima.

    Google Scholar 

  • Etkin, N. L., and P. J. Ross. 1991. Recasting malaria, medicine and meals: a perspective on disease adaptation. Pages 230–258in L. Romanucci-Ross, D. E. Moerman and L. R. Tancredi, eds., The anthropology of medicine: from culture to method. 2nd Edition. Bergin & Garvey, New York.

    Google Scholar 

  • Fanshawe, D. B. 1948. Forest products of British Guiana. Part II. Minor forest products. Forestry Bulletin 2(n.s.):7–81.

    Google Scholar 

  • Flores, F. A. 1984. Notes on some medicinal and poisonous plants of Amazonian Peru. Advances in Economic Botany 1:1–8.

    Google Scholar 

  • Freise, F. W. 1933. Plantas medicinais brasileiras. Boletim de Agricultura, São Paulo 1933:252–494.

    Google Scholar 

  • García-Barriga, H. 1992. Flora medicinal de Colombia. 2nd Edition. Tercer Mundo, Bogotá.

    Google Scholar 

  • Gbeassor, M., A. Y. Kedjagni, K. Koumaglo, C. de Souza, K. Agbo, K. Aklikokou, and K. A. Amegbo. 1990. In vitro antimalarial activity of six medicinal plants. Phytotherapy Research 4(3): 115–117.

    Article  Google Scholar 

  • Gessler, M. C, D. E. Msuya, M. H. H. Nkunya, L. B. Mwasumbi, A. Schar, M. Heinrich, and M. Tanner. 1995. Traditional healers in Tanzania: the treatment of malaria with plant remedies. Journal of Ethnopharmacology 48:131–144.

    Article  PubMed  CAS  Google Scholar 

  • Grenand, P., C. Moretti, and H. Jacquemin. 1987. Pharmacopées traditionelles en Guyane. ORSTOM, Paris.

    Google Scholar 

  • Heckel, E. 1897. Les plantes médicinales et toxiques de la Guiane FranÇaise. Protat Fréres, Macon, France.

    Google Scholar 

  • Hemming, J. 1990. Roraima: Brazil’s northernmost frontier. University of London Institute of Latin American Studies Research Paper 20.

  • Hodge, W. H., and D. Taylor. 1957. The ethnobotany of the Island Caribs of Dominica. Webbia 12(2):513–644.

    Google Scholar 

  • House, P. R., S. Lagos-Witte, L. Ochoa, C. Torres, T. Mejía, and M. Rivas. 1995. Plantas medicinales comunes de Honduras. UNAH, Tegucigalpa.

    Google Scholar 

  • Johnston, M., and A. Colquhoun. 1996. Preliminary ethnobotanical survey of Kurupukari: an Amerindian settlement of Central Guyana. Economic Botany 50(2): 182–194.

    Google Scholar 

  • Klayman, D. L. 1985.Qinghaosu (Artemisinin): an antimalarial drug from China. Science 228:1049–1055.

    Article  PubMed  CAS  Google Scholar 

  • La Rotta,C. 1983. Observaciones etnobotánicas so-bre algunas especies utilizadas por la comunidad indígena Andoque (Amazónas, Colombia). DAINCO, Bogotá.

    Google Scholar 

  • Lachman-White, D. A., C. D. Adams, and U. O.’D. Trotz. 1987. A guide to the medicinal plants of coastal Guyana. Commonwealth Science Council, London.

    Google Scholar 

  • Leaman, D. J., J. T. Arnason, R. Yusuf, H. Sangat-Roemantyo, H. Soedjito, C. K. Angerhofer, and J. M. Pezzuto. 1995. Malaria remedies of the Apo Kayan, East Kalimantan, Indonesian Borneo: a quantitative assessment of local concensus as an indicator of biological efficacy. Journal of Ethnopharmacology 49(1):1–16.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, W. H., M. Elvin-Lewis, and M. C. Gnerre. 1987. Introduction to the ethnobotanical pharma-copeia copeia of the Amazonian Jívaro of Peru. Pages 96–103in A. J. Leeuwenberg, comp., Medicinal and poisonous plants of the tropics. Pudoc, Wageningen.

    Google Scholar 

  • Loizaga, N. S., and L. C. Sagastume. 1935. Malaria treatment with ’Quechuol-Dominguez’. Semana Médica (Buenos Aires) 1935(2):562–566.

    Google Scholar 

  • Lorenzi, H. 1991. Plantas daninhas do Brasil: terrestres, aquáticas, parasitas, toxicas e medicinais. 2a Edicão. Editora Plantarum, Nova Odessa.

    Google Scholar 

  • MacMillan, G. J. 1995. At the end of the rainbow? Gold, land and people in the Brazilian Amazon. Earthscan Publications, London.

    Google Scholar 

  • Makinde, J. M., P. O. Obih, and A. A. Jimoh. 1987. Effect ofSolanum erianthum aqueous leaf extract onPlasmodium berghei in mice. African Journal of Medical Science 16(4): 193–196.

    CAS  Google Scholar 

  • Mansell Prothero, R. 1995. Malaria in Latin America: environmental and human factors. Bulletin of Latin American Research 14(3):357–365.

    Article  Google Scholar 

  • Martin, G. J. 1995. Ethnobotany. A methods manual. Chapman & Hall, London.

    Google Scholar 

  • Martin, P. H., and M. G. Lefebvre. 1995. Malaria and climate: sensitivity of malaria potential transmission to climate. Ambio 24(4):200–207.

    Google Scholar 

  • Milliken, W. n.d. Plants for Malaria. A bibliographic survey of plants used in the treatment of malaria and fevers in northern Latin America. Royal Botanic Gardens, Kew.

  • —,and Ratter, J. A. 1989. The vegetation of the Una de Maracá. Royal Botanic Garden, Edinburgh.

    Google Scholar 

  • —,and B. Albert. 1996. The use of medicinal plants by the Yanomami Indians of Brazil. Economic Botany 50(1): 10–25.

    Google Scholar 

  • —,and —. 1997. The use of medicinal plants by the Yanomami Indians of Brazil, Part II. Economic Botany 51(3):264–278.

    Google Scholar 

  • —,R. P. Miller, S. R. Pollard, and E. V. Wandelli. 1992. Ethnobotany of the Waimiri Atroari Indians of Brazil. Royal Botanic Gardens, Kew.

    Google Scholar 

  • Misra, P., N. L. Pal, P. Y. Guru, J. C. Katiyar, and J. S. Tandon. 1991. Antimalarial activity of traditional plants against erythrocytic stages ofPlasmodium berghei. International Journal of Pharmacognosy 29(l):19–23.

    Article  Google Scholar 

  • Morton, J. F. 1981. Atlas of medicinal plants of Middle America. C. Thomas, Springfield, Illinois.

    Google Scholar 

  • Ohigashi, H., M. A. Huffmann, D. Izutsu, K. Koshimizu, M. Kawanaka, H. Sugiyama, G. C. Kirby, D. C. Warhurst, D. Allen, C. W. Wright, J. D. Phillipson, P. Timmon-David, F. Delnas, R. Elias, and G. Balansard. 1993. Toward the chemical ecology of medicinal plant use in chimpanzees: the case ofVernonia amygdalina, a plant used by wild chimpanzees for parasite-related diseases. Journal of Chemical Ecology 20:541–553.

    Article  Google Scholar 

  • Ortizde Montellano,B. R. 1990. Aztec medicine, health and nutrition. Rutgers University Press, New Brunswick.

    Google Scholar 

  • Phillipson, J. D., M. J. O’Neill, C. W. Wright, D. H. Bray, and D. C. Warhurst. 1987. Plants as sources of antimalarial and amoebicidal compounds. Pages 70–79in A. J. M. Leeuwenberg, comp., Medicinal and poisonous plants of the tropics. Centre for Agricultural Publishing and Documentation, Pudoc, Wageningen.

    Google Scholar 

  • —,and C. W. Wright. 1991a. Antiprotozoal agents from plant sources. Planta Medica 57(suppl.):53–59.

    Article  Google Scholar 

  • —,and —. 1991b. Can ethnopharmacology contribute to the development of antimalarial agents? Journal of Ethnopharmacology 32:155–165.

    Article  PubMed  CAS  Google Scholar 

  • Pittier, H. 1978. Las plantas usuales de Venezuela. Fundacion Eugenio Mendoza.

  • Prance, G. T. 1972. An ethnobotanical comparison of four tribes of Amazonian Indians. Acta Amazonica 2(2):7–27.

    Google Scholar 

  • Rocha, A. I.de, M. L. H.da Silva, A. P. Mourao, and M. P. Cava. 1968. A presenca de alkaloides em espécies botanicas da Amazônia. CNPQ/INPA, Publicacâo No. 12. Manaus.

    Google Scholar 

  • Rutter, R. A. 1990. Catalogo de plantas utiles de la Amazonia Peruana. Instituto Linguistico de Verano, Pucallpa, Peru.

    Google Scholar 

  • Sala-Neto, F., J. S.da Silva, R. O. Pires, N. P. Nascimento, C. Brenner, J. P. Bouhli, and C. E. Tosta. 1992. Uma nova metodologia para a avaliacâo da atividade antimalarica de produtos vegetais: aplicacâo ao estudo de 83 espécimes da flora brasileira. Anais do Simposio de Malaria. Revista da Sociedade Brasileira de Medicina Tropical 25(supl. II):92.

    Google Scholar 

  • Saraf, S., V. K. Dixit, S. C. Tripathi, and G. K. Patnaik. 1994. Antihepatotoxic activity ofCassia occidentalis. International Journal of Pharmacognosy 32(2): 178–183.

    Google Scholar 

  • Schomburgk, R. 1848. Travels in British Guiana 1840–1844. Transl. W. E. Roth. J. J. Weber, Leipzig.

  • Schultes, R. E., and R. F. Raffauf. 1990. The healing forest—medicinal and toxic plants of the northwest Amazonia. Historical, ethno-and economic botany series, Vol. 2. Dioscorides Press, Portland, Oregon.

    Google Scholar 

  • —,and —. 1994. De plantis toxicariis e mundo novo tropicale commentationes XXXIX. Febrifuges of northwest Amazonia. Harvard Papers in Botany 5:52–68.

    Google Scholar 

  • Spencer, C. F., F. R. Koniuszy, E. F. Rogers Jr,J. Shavel, N. R. Easton, E. A. Kaezka Jr,F. A. Kuehl, R. F. Phillips, A. Walti, K. Folkers, C. Malanga, and A. O. Seeler. 1947. Survey of plants for antimalarial activity. Lloydia 10:145–174.

    Google Scholar 

  • Stahel, G. 1944. De nuttige planten van Suriname. Departement Landbouwproelstation in Suriname, Bulletin No. 59.

  • SUCAM. 1991. Malária dados epidemiologicos de Roraima, 1888–1990. Internal Report.

  • Takeuchi, M. 1960. A estrutura da vegetaÇão na Amazônia II—as savanas do norte da Amazônia. Boletim do Museu Paraense Emílio Goeldi, N. S. Botănica. No. 7.

  • Trager, W., and J. B. Jensen. 1976. Human malaria parasites in continuous culture. Science 193:673–675.

    Article  PubMed  CAS  Google Scholar 

  • Wasicky, R., O. Unti, and E. Barbieri. 1942. Quinine and alkaloids in Brazil. Anais da Faculdade de Farmácia e Odontologia, São Paulo 3:137.

    Google Scholar 

  • Weenen, H., M. H. H. Nkunya, D. H. Bray, L. B. Mwasumbi, L. S. Kinabo, and V. A. E. B. Kilimali. 1990. Antimalarial activity of Tanzanian plants. Planta Medica 56(4):368–370.

    Article  PubMed  CAS  Google Scholar 

  • Wilbert, W., and G. Haiek. 1991. Phytochemical screening of a Warao pharmacopoeia employed to treat gastrointestinal disorders. Journal of Ethno-pharmacology 34:7–11

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Milliken, W. Traditional anti-malarial medicine in Roraima, Brazil. Econ Bot 51, 212–237 (1997). https://doi.org/10.1007/BF02862091

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02862091

Key Words

Navigation