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The lymphocyte plasma membrane: Locus of control in the immune response

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Summary

The lymphocyte plasma membrane is the locus of events which control the immune response. T and B lymphocytes, which mediate cellular and humoral immunity respectively, show distinctive plasma membrane morphologies and cell surface receptors. The dynamic state of these plasma membrane components is emphasized by their lateral mobility in the fluid plane of the membrane, as well as variation in their structure or expression as the lymphocyte proliferates and differentiates in response to stimulation by antigen or mitogens. The best understood membrane glycoproteins are surface membrane immunoglobulins that serve as antigen receptors on B cells, and the histocompatability-β 2 microglobulin complex that has an immunoglobulin-like structure. Other less well defined surface structures showing modulation during the cell cycle may affect growth regulation of proliferating lymphocytes. Some of these are shared by fetal and neoplastic cells. Major theories of lymphocyte signaling are discussed, and the early events in lymphocyte activation are reviewed. While a complete model encompassing all these early events is not yet possible, the central issues can be usefully discussed in terms of receptor-transducer-effector concepts derived by strong parallels from a knowledge of hormone-membrane interactions.

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References

  1. Polliack, A., N. Lampen, B. D. Clarkson, E. DeHarven, Z. Bentwich, F. P. Siegal, and H. G. Kunkel. 1973. Identification of human B and T lymphocytes by scanning electron microscopy. J. Exp. Med. 138: 607–624.

    Article  PubMed  CAS  Google Scholar 

  2. Sullivan, A. K., L. S. Adams, I. Silke, and L. M. Jerry. 1974. “Hairy” B cells and “smooth” T cells. New Engl. J. Med. 290: 689–690.

    Article  Google Scholar 

  3. Sciorra, L., and C. Eckhert. 1974. Distinguishing T and B lymphocytes by light microscopy and Nomarski optics. Lancet ii: 1526.

    Article  Google Scholar 

  4. Porter, K., D. Prescott, and J. Frye. 1973. Changes in surface morphology of Chinese hamster ovary cells during the cell cycle. J. Cell Biol. 57: 815–836.

    Article  PubMed  CAS  Google Scholar 

  5. Rubin, R. W., and L. P. Everhart. 1973. The effect of cell-to-cell contact on the surface morphology of Chinese hamster ovary cells. J. Cell Biol. 57: 837–844.

    Article  PubMed  CAS  Google Scholar 

  6. Lin, P. S., D. F. Wallach, and S. Isai. 1973. Temperature-induced variations in the surface topology of cultured lymphocytes are revealed by scanning electron microscopy. Proc. Natl. Acad. Sci. USA. 70: 2492–2496.

    Article  PubMed  CAS  Google Scholar 

  7. Rambourg, A., and C. P. Leblond. 1967. Electron microscope observations on the carbohydrate-rich cell coat present at the surface of cells in the rat. J. Cell Biol. 32: 27–53.

    Article  PubMed  CAS  Google Scholar 

  8. Santer, V., R. E. Cone, and J. J. Marchalonis. 1973. The Glycoprotein surface coat on different classes of murine lymphocytes. Exp. Cell Res. 79: 404–416

    Article  PubMed  CAS  Google Scholar 

  9. Wioland, M., D. Sablovic, and C. Burg. 1972. Electrophoretic mobility of T and B cells. Nature. 237: 274–276.

    Article  CAS  Google Scholar 

  10. Raff, M. C. 1971. Surface antigenic markers for distinguishing T and B lymphocytes. Transplant Rev. 6: 52–80.

    PubMed  CAS  Google Scholar 

  11. McArthur, W. P., J. Chapman, and G. J. Thorbecke. 1971. Immunocompetent cells of the chicken. I. Specific surface antigenic markers on bursa and thymus cells. J. Exp. Med. 134: 1036–1045.

    Article  PubMed  CAS  Google Scholar 

  12. Hudson, L., and I. M. Roitt. 1973. Immunofluorescent detection of surface antigens specific to T and B lymphocytes in the chicken. Eur. J. Immunol. 3: 63–67.

    Article  PubMed  CAS  Google Scholar 

  13. Böyum, A. 1968. Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21: Supplementum 97.

  14. Raff, M. C. 1973. T and B lymphocytes and immune responses. Nature. 242: 19–23.

    Article  PubMed  CAS  Google Scholar 

  15. Möller, G. 1973. T and B lymphocytes in Humans. Transplant Rev. Vol. 16.

  16. Greaves, M. F., J. J. T. Owen, and M. C. Raff. 1974.T and B Lymphocytes. Origins, Properties and Roles in Immune Responses. Amer. Elsevier Pub. Co. Inc., New York.

    Google Scholar 

  17. Ainti, F., J.-C. Cerottini, R. R. A. Coombs, M. Cooper, H. B. Dickler, S. Frøland, H. H. Fudenberg, M. F. Greaves, H. M. Grey, H. G. Kunkel, J. Natvig, J.-L. Preud’homme, E. Rabellino, R. E. Ritts, D. S. Rowe, M. Seligmann, F. P. Siegal, J. Stjernswärd, W. D. Terry, and J. Wybran. 1975. International Union of Immunological Societies (IUIS), Report—July, 1974. Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood. Clin. Immunol. Immunopath. 3: 584–597.

    Article  Google Scholar 

  18. Wybran, J., and H. H. Fudenberg. 1974. Editorial: How clinically useful is T and B cell quantitation? Ann. Int. Med. 80: 765–767.

    PubMed  CAS  Google Scholar 

  19. Jondal, M., D. Holm, and H. J. Wigzell. 1972. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming non-immune rosettes with SRBC. J. Exp. Med. 136: 207–215.

    Article  PubMed  CAS  Google Scholar 

  20. Brain, P., and R. H. Marston. 1973. Rosette formation by human T and B lymphocytes. Eur. J. Immunol. 3: 6–9.

    Article  PubMed  CAS  Google Scholar 

  21. Wybran, J., M. C. Carr, and H. H. Fudenberg. 1972. The human rosette-forming cell as a marker of a population of thymus-derived cells. J. Clin. Invest. 51: 2537–2543.

    Article  PubMed  CAS  Google Scholar 

  22. Frøland, S. S. 1972. Binding of sheep erythrocytes to human lymphocytes. A probable marker of T lymphocytes. Scand. J. Immunol. 1: 269–280.

    Article  PubMed  Google Scholar 

  23. Siegel, I. 1973. Thymocytes rosettes. N. Engl. J. Med. 289: 327.

    PubMed  CAS  Google Scholar 

  24. Kaplan, J. 1975. Human T lymphocytes form rosettes with autologous and allogeneic human red blood cells. Clin. Immunol. Immunopathol. 3: 471–475.

    Article  PubMed  CAS  Google Scholar 

  25. Baxley, G., G. B. Bishop, A. G. Cooper, and H. H. Wartis. 1973. Rosetting of human red blood cells to thymocytes and thymus derived cells. Clin. Exp. Immunol. 15: 385–392.

    PubMed  CAS  Google Scholar 

  26. Wybran, J., and H. H. Fudenberg. 1973. Thymus derived rosette-forming states: cancer, lymphoma, bacterial and viral infections, and other diseases. J. Clin. Invest. 52: 1026–1032.

    Article  PubMed  CAS  Google Scholar 

  27. Williams, R. C., J. R. DeBoard, O. J. Mellbye, R. P. Messner, and F. D. Linström. 1973. Studies of T and B lymphocytes in patients with connective tissue diseases. J. Clin. Invest. 52: 283–295.

    Article  PubMed  Google Scholar 

  28. Smith, R. W., W. D. Terry, D. N. Buell, and K. W. Sell. 1973. An antigenic marker for human thymic lymphocytes. J. Immunol. 110: 884–887.

    PubMed  CAS  Google Scholar 

  29. Aiuti, F., and H. Wigzell. 1973. Function and distribution pattern of human T lymphocytes. I. Production of anti-T lymphocyte specific sera as estimated by cytotoxicity and elimination of function of lymphocytes. Clin. Expt. Immunol. 13: 171–181.

    CAS  Google Scholar 

  30. Greaves, M. F. 1973. Surface markers for human T and B lymphocytes. Curr. Titles Immunol. Transplant. Allergy 1: 193–198.

    Google Scholar 

  31. Frøland, S. S., and J. B. Natvig. 1972. Class, subclass and allelic exclusion of membrane-bound IgG of human B lymphocytes. J. Exp. Med. 136: 409–414.

    Article  PubMed  Google Scholar 

  32. Grey, H. M., E. Rabellino, and B. Pirofsky. 1971. Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogamma-globulinaemia, cellular immune deficiency and chronic lymphocytic leukemia. J. Clin. Invest. 50: 2368–2375.

    Article  PubMed  CAS  Google Scholar 

  33. Papamichail, M., J. C. Brown, and E. J. Holborow. 1971. Immunoglobulins on the surface of human lymphocytes. Lancet ii: 850–852.

    Article  Google Scholar 

  34. Wilson, J. D., and G. J. V. Nossal. 1971. Identification of human T and B lymphocytes in normal peripheral blood and in chronic lymphocytic leukemia. Lancet ii: 788–791.

    Article  Google Scholar 

  35. Siegal, F. P., B. Pernis, and H. G. Kunkel. 1971. Lymphocytes in human immunodeficiency states: a study of membrane-associated immunoglobulins. Eur. J. Immunol. 1: 482–491.

    Article  PubMed  CAS  Google Scholar 

  36. Cooper, M. D., and A. R. Lawton. 1972. Circulating B cells in patients with immunodeficiency. Amer. J. Path. 69: 513–528.

    PubMed  CAS  Google Scholar 

  37. Jondal, M., H. Wigzell, and F. Quito. 1973. Human lymphocyte subpopulations: classification according to surface markers and/or functional characteristics. Transplant. Rev. 16: 163–195.

    PubMed  CAS  Google Scholar 

  38. Lay, W. H., and V. Nussenzweig. 1968. Receptors for complement of leukocytes. J. Exp. Med. 128: 991–1009.

    Article  PubMed  CAS  Google Scholar 

  39. Bianco, C., R. Patrick, and V. Nussenzweig. 1970. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J. Exp. Med. 132: 702–720.

    Article  PubMed  CAS  Google Scholar 

  40. Nussenzweig, V. 1974. Receptors for immune complexes on lymphocytes. Adv. Immunol. 19: 217–258.

    Article  PubMed  CAS  Google Scholar 

  41. Nussenzweig, V., C. Bianco, P. Dukor, and A. Eden. 1971. Receptors for C3 on B lymphocytes: possible role in the immune response. In: B. Amos (Ed.),Progress in Immunology. Academic Press, New York, pp. 73–82.

    Google Scholar 

  42. Ross, G. D., E. M. Rabellino, M. J. Polley, and H. M. Grey. 1973. Combined studies of complement receptor and surface immunoglobulin-bearing cells and sheep erythrocyte rosette-forming cells in normal and leukemic human lymphocytes. J. Clin. Invest. 52: 377–385.

    Article  PubMed  CAS  Google Scholar 

  43. Unanue, E. R., and M. J. Karnovsky. 1973. Redistribution and fate of Ig complexes on surface of B lymphocytes: functional implications and mechanisms. Transplant. Rev. 14: 184–210.

    PubMed  CAS  Google Scholar 

  44. Eden, A., G. W. Miller, and V. Nussenzweig. 1973. Human lymphocytes bear membrane receptors for C3b and C3d. J. Clin. Invest. 52: 3239–3242.

    Article  PubMed  CAS  Google Scholar 

  45. Okada, H., and K. Nishioka. 1973. Complement receptors on cell membrane. I. Evidence for two complement receptors. J. Immunol. 111: 1444–1449.

    PubMed  CAS  Google Scholar 

  46. Eden, A., C. Bianco, and V. Nussenzweig. 1971. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. Specific isolation. Cell Immunol. 2: 658–659.

    Article  PubMed  CAS  Google Scholar 

  47. Gelfand, M. C., G. E. Elfenbeen, M. M. Frank, and W. E. Paul. 1974. Ontogeny of B lymphocytes: II. Relative rates of appearance of lymphocytes bearing surface immunoglobulin and complement receptors. J. Exp. Med. 139: 1125–1141.

    Article  PubMed  CAS  Google Scholar 

  48. Gelfand, M. C., D. H. Sachs, R. Liebman, and W. E. Paul. 1974. Ontogeny of B lymphocytes 3. H-2 linkage of a gene controlling the rate of appearance of complement-receptor lymphocytes. J. Exp. Med. 139: 1142–1153.

    Article  PubMed  CAS  Google Scholar 

  49. Uhr, J. W., and J. M. Phillips. 1966.In vitro sensitization of phagocytes and lymphocytes by antigen-antibody complexes. Ann. N.Y. Acad. Sci. 129: 793–798.

    Article  CAS  Google Scholar 

  50. Brown, J. C., D. G. DeJesus, E. J. Holborow, and G. Harris. 1970. Lymphocyte-medicated transport of aggregated human gamma-globulin into germinal centre areas of normal mouse spleen. Nature 228: 367–369.

    Article  PubMed  CAS  Google Scholar 

  51. Basten, A., J. F. A. P. Miller, J. Sprent, and J. Pye. 1972. A receptor for antibody on B lymphocytes. I. Method of detection and functional significance. J. Exp. Med. 135: 610–626.

    Article  PubMed  CAS  Google Scholar 

  52. Dickler, H. B., and H. G. Kunkel. 1972. Interaction of aggregated-globulin with B lymphocytes. J. Exp. Med. 136: 191–196.

    Article  PubMed  CAS  Google Scholar 

  53. Paraskevas, F., S. T. Lee, K. B. Orr, and L. G. Israels. 1972. A receptor for Fc on mouse B-lymphocytes. J. Immunol. 108: 1319–1327.

    PubMed  CAS  Google Scholar 

  54. Hallberg, T., D. Haegert, G. P. Clein, R. R. A. Coombs, A. Feinstein, and B. W. Gurner. 1974. Observations on the mixed antiglobulin reaction as a test for immunoglobulin-bearing lymphocytes in normal persons and in patients with chronic lymphatic leukemia. J. Immunol. Meth. 4: 317–332.

    Article  CAS  Google Scholar 

  55. Yoshida, T. O., and B. Andersson. 1972. Evidence for a receptor recognizing antigen complexed immunoglobulin on the surface of activated mouse thymus lymphocytes. Scand. J. Immunol. 1: 401–408.

    Article  PubMed  CAS  Google Scholar 

  56. Frøland, S. S., F. Wisløff, and T. E. Michaelsen. 1974. Human lymphocytes with receptors for IgG. A population of cells distinct from T-and B-lymphocytes. Int. Arch. Allergy Appl. Immunol. 47: 124–138.

    PubMed  Google Scholar 

  57. Aiuti, E., V. Lacava, J. A. Garofalo, R. D’Amelio, and C. D’Asero. 1973. Surface markers on human lymphocytes: studies of normal subjects and of patients with primary immunodeficiencies. Clin. Exp. Immunol. 15: 43–52.

    PubMed  CAS  Google Scholar 

  58. Yata, J., and I. Tsukimoto. 1972. Maturation of cell-surface structure of human B lymphocytes. Lancet ii: 1425.

    Article  Google Scholar 

  59. Frøland, S. S., and J. B. Natvig. 1973. Identification of three different human lymphocyte populations by surface markers. Transplant. Rev. 16: 114–162.

    PubMed  Google Scholar 

  60. Hayward, A. R., and M. F. Greaves. 1975. Central failure of B-lymphocyte induction in Pan-hypogammaglobulinemia. Clin. Immunol. Immunopathol. 3: 461–470.

    Article  PubMed  CAS  Google Scholar 

  61. Preud’homme, J. L., and M. Seligmann. 1972. Auto-human immunoglobulin G activity of membrane-bound monoclonal immunoglobulin M in lymphoproliferative disorders. Proc. Natl. Acad. Sci. U.S.A. 69: 2132–2135.

    Article  PubMed  CAS  Google Scholar 

  62. Davey, M. J., and G. L. Asherson. 1967. Cytophilic antibody. I. Nature of the macrophage receptor. Immunology 12: 13–20.

    PubMed  CAS  Google Scholar 

  63. Weissman, G., A. Brand, and E. C. Franklin. 1974. Interaction of immunoglobulins with liposomes. J. Clin. Invest. 53: 536–543.

    Article  Google Scholar 

  64. Nussenzweig, V. 1974. Receptors for immune complexes on lymphocytes. Adv. Immunol. 19: 217–258.

    Article  PubMed  CAS  Google Scholar 

  65. Mantovani, B., M. Rabinovitch, and V. Nussenzweig. 1972. Phagocytosis of immune complexes by macrophages. Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG). J. Exp. Med. 135: 780–792.

    Article  PubMed  CAS  Google Scholar 

  66. Taylor, R. B., W. P. H., Duffus, M. C. Raff, and S. dePetris. 1971. Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by anti-immunoglobulin antibody. Nature [New Biol. 233: 225–229.

    CAS  Google Scholar 

  67. Unanue, E. R., W. D. Perkins, and M. J. Karnovsky. 1972. Endocytosis by lymphocytes of complexes of anti-IgG with membrane-bound IgG J. Immunol. 108: 569–572.

    PubMed  CAS  Google Scholar 

  68. Dukor, P., G. Schumann, R. H. Gisler, M. Dierich, W. König, U. Hadding, and D. Bitter-Suermann. 1974. Complement-dependent B-cell activation by cobra venom factor and other mitogens? J. Exp. Med. 139: 337–354.

    Article  PubMed  CAS  Google Scholar 

  69. Pepys, M. B. 1972. Role of complement in induction of the allergic response. Nature [New Biol.] 237: 157–159.

    Article  CAS  Google Scholar 

  70. Herber, H., M. J. Polley, and W. D. Linscott. 1968. Human monocytes distinct receptor sites for the third component of complement and for immunoglobulin G. Science 162: 1281–1283.

    Article  Google Scholar 

  71. Henson, P. M. 1969. The adherence of leukocytes and platelets induced by fixed IgG antibody or complement. Immunol. 16: 107–121.

    CAS  Google Scholar 

  72. Henson, P. M., and C. G. Cochrane. 1969. Immunological induction of increased vascular permeability. II. Two mechanisms of histamine release from rabbit platelets involving complement. J. Exp. Med. 129: 167–184.

    Article  PubMed  CAS  Google Scholar 

  73. Weissman, G., R. B. Zurier, P. J. Spieleret al. 1971. Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles. J. Exp. Med. 134: Supplement 1495. Part 2.

  74. Brown, J. C., D. G. DeJenes, E. J. Holborowet al. 1970. Lymphocyte-mediated transport of aggregated human gamma-globulin into germinal centre areas of normal mouse spleen. Nature. 228: 367–376.

    Article  PubMed  CAS  Google Scholar 

  75. Perlmann, P., and H. Perlmann. 1970. Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes. Cell Immunol. 1: 300–315.

    Article  PubMed  CAS  Google Scholar 

  76. O’Toole, C., P. Perlmann, H. Wigzell, B. Unsgaard, and C. G. Zetterlund. 1973. Lymphocyte cytotoxicity in bladder cancer. No requirement for thymus-derived effector cells? Lancet i: 1085–1088.

    Article  Google Scholar 

  77. Seemayer, T. A., L. M. Jerry, L. Shapiro. 1976. Spindle-cell Epithelial Thymoma. Am. J. Clin. Path. (In Press).

  78. Harris, A. W., A. D. Bankhurst, S. Mason, and N. L. Warner. 1973. Differentiated functions expressed by cultured mouse lymphoma cells. II. Theta antigen, surface immunoglobulin and a receptor for antibody on cells of a thymoma cell line. J. Immunol. 110: 431–438.

    PubMed  CAS  Google Scholar 

  79. West, W., and R. B. Herberman. 1974. A human lymphoid cell line with receptors for both sheep red blood cells and complement. Cell Immunol. 14: 139–145.

    Article  PubMed  CAS  Google Scholar 

  80. Shevach, E., R. Edelson, M. Frank, M. Lutzner, and I. Green. 1974. A human leukemia cell with both B and T cell surface receptors. Proc. Natl. Acad. Sci. U.S.A. 71: 863–866.

    Article  PubMed  CAS  Google Scholar 

  81. Bentwich, Z., S. D. Douglas, F. P. Siegal, and H. G. Kunkel. 1973. Human lymphocyte-sheep erythrocyte rosette formation: some characteristics of the interaction. Clin. Immunol. Immunopathol. 1: 511–522.

    Article  PubMed  CAS  Google Scholar 

  82. Killander, D., E. Klein, and A. Levin. 1974. Expression of membrane-bound IgM and HL-antigens on lymphoblastoid cells in different stages of the cell cycle. Eur. J. Immunol. 4: 327–332.

    Article  PubMed  CAS  Google Scholar 

  83. Papenhauser, P., P. Papageorgiou, and K. Hirschhorn. 1975. Complement receptor in synchronized cultures of human hematopoietic cell lines. J. Immunol. 114: 519–521, Part 2.

    Google Scholar 

  84. Ehrlich, P. 1900. Croonian lecture. On immunity with special reference to cell life. Proc. R. Soc. Med. 66: 424–435.

    Article  CAS  Google Scholar 

  85. Burnet F. M. 1959.The Clonal Selection Theory of Acquired Immunity. Cambridge University Press, London.

    Google Scholar 

  86. Frøland, S. S., J. B. Natvig, and P. Birdal. 1971. Surface-bound immunoglobulin as a marker of B lymphocytes in man. Nature [New Biol.] 234: 251–252.

    Google Scholar 

  87. Grey, H. M., E. Rabellino, and B. Pirofsky. 1971. Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypergammaglobulinemia, cellular immune deficiency and chronic lymphatic leukemia. J. Clin. Invest. 50: 2368–2375.

    Article  PubMed  CAS  Google Scholar 

  88. Rabellino, E., and H. M. Grey. 1971. Immunoglobulin on the surface of lymphocytes. III. Bursal origin of surface immunoglobulins on chicken lymphocytes. J. Immunol. 106: 1418–1420.

    PubMed  CAS  Google Scholar 

  89. Marchalonis, J. J., and R. E. Cone. 1973. Biochemical and biological characteristics of lymphocyte surface immunoglobulin. Transplant. Rev. 14: 3–49.

    PubMed  CAS  Google Scholar 

  90. Unanue, E. R., and M. J. Karnovsky. 1973. Redistribution and fate of Ig complexes on surface of B lymphocytes: functional implications and mechanisms. Transplant. Rev. 14: 184–210.

    PubMed  CAS  Google Scholar 

  91. Frøland, S. S., and J. B. Natvig. 1972. Class, subclass and allelic exclusion of membranebound Ig of human B lymphocytes. J. Exp. Med. 136: 409–414.

    Article  PubMed  Google Scholar 

  92. Natvig, J. B., and H. G. Kunkel. 1973. Human immunoglobulins: classes, subclasses, genetic variants and idiotypes. Adv. Immunol. 16: 1–59.

    Article  PubMed  CAS  Google Scholar 

  93. Wernet, P., T. Feizi, and H. G. Kunkel. 1972. Idiotypic determinants of immunoglobulin M detected on the surface of human lymphocytes by cytotoxicity assays. J. Exp. Med. 136: 650–655.

    Article  PubMed  CAS  Google Scholar 

  94. Nossal, G. J., A. Szenberg, G. L. Ada, and C. M. Austin. 1964. Single cell studies on 19S antibody production. J. Exp. Med. 119: 485–502.

    Article  PubMed  CAS  Google Scholar 

  95. Cooper, M. D., A. R. Lawton, and P. W. Kincade. 1972. A two-stage model for development of antibody-producing cells. Clin. Exp. Immunol. 11: 143–149.

    PubMed  CAS  Google Scholar 

  96. Warner, N. L. 1974. Membrane immunoglobulins and antigen receptors on B and T lymphocytes. Adv. Immunol. 19: 67–216.

    Article  PubMed  CAS  Google Scholar 

  97. Rowe, D. S., P. A. Crabbe, and M. W. Turner. 1968. Immunoglobulin D in serum, body fluids and lymphoid tissues. Clin. Exp. Immunol. 3: 477–490.

    PubMed  CAS  Google Scholar 

  98. Vitteta, E. S., and J. W. Uhr. 1973. Synthesis, transport, dynamics and fate of cell surface Ig and alloantigens in murine lymphocytes. Transplant Rev. 14: 50–75.

    Google Scholar 

  99. Baur, S., I. Schenkin, and J. W. Uhr. 1972. Cell surface immunoglobulin. I. Isolation and characterization of immunoglobulin from murine myeloma cells. J. Immunol. 108: 748–754.

    PubMed  CAS  Google Scholar 

  100. Pernis, B., L. Forni, and L. Amante. 1970. Immunoglobulin spots on the surface of rabbit lymphocytes. J. Exp. Med. 132: 1001–1018.

    Article  PubMed  CAS  Google Scholar 

  101. Karnovsky, M. J., E. R. Unanue, and M. Leventhal. 1972. Ligand-induced movement of lymphocyte membrane macromolecules. II. Mapping of surface moieties. J. Exp. Med. 136: 907–930.

    Article  PubMed  CAS  Google Scholar 

  102. Karnovsky, M. J., and E. R. Unanue. 1973. Mapping and migration of lymphocyte surface macromolecules. Fed. Proc. 32: 55–59.

    PubMed  CAS  Google Scholar 

  103. Taylor, R. B., W. P. H. Duffus, M. C. Raff, and S. DePetris. 1971. Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by anti-immunoglobulin antibody. Nature [New Biol.] 233: 225–229.

    CAS  Google Scholar 

  104. Loor, L., L. Forni, and B. Pernis. 1972. The dynamic state of the lymphocyte membrane. Factors affecting the distribution and turnover of surface immunoglobulins. Europ. J. Immunol. 2: 203–212.

    Article  CAS  Google Scholar 

  105. DePetris, S., and M. C. Raff. 1973. Normal distribution, patching and capping of lymphocyte surface immunoglobulin studied by electron microscopy. Nature [New Biol.] 241: 257–259.

    CAS  Google Scholar 

  106. Unanue, E. R., W. D. Perkins, and M. J. Karnovsky. 1972. Ligand-induced movement of lymphocyte membrane macromolecules. 1. Analysis of immunofluorescence and ultrastructural radioautography. J. Exp. Med. 136: 885–906.

    Article  PubMed  CAS  Google Scholar 

  107. Yahara, I., and G. M. Edelman. 1972. Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A. Proc. Natl. Acad. Sci. U.S.A. 69: 608–612.

    Article  PubMed  CAS  Google Scholar 

  108. Ashman, R., and M. C. Raff. 1973. Direct demonstration ofθ-positive antigen-binding cells with antigen-induced movement of T cell receptors. J. Exp. Med. 137: 69–84.

    Article  PubMed  CAS  Google Scholar 

  109. Raff, M. C., and S. DePetris. 1973. Movement of lymphocyte surface antigens and receptors: the fluid nature of the lymphocyte plasma membrane and its immunologic significance. Fed. Proc. 32: 48–54.

    PubMed  CAS  Google Scholar 

  110. Sullivan, A. L., P. M. Grimley, and H. Metzger. 1971. Electron microscopic localization of immunoglobulin E on the surface membrane of human basophils. J. Exp. Med. 134: 1403–1416.

    Article  PubMed  CAS  Google Scholar 

  111. Edidin, M., and A. Weiss. 1972. Antigen cap formation in cultured fibroblasts: a reflection of membrane fluidity and of cell mobility. Proc. Natl. Acad. Sci. U.S.A. 69: 2456–2459.

    Article  PubMed  CAS  Google Scholar 

  112. Melchers, F., and J. Andersson. 1973. Synthesis, surface deposition and secretion of immunoglobulin M in bone marrow-derived lymphocytes before and after mitogenic stimulation. Transplant. Rev. 14: 76–130.

    PubMed  CAS  Google Scholar 

  113. Vitetta, E. S., S. Baur, and J. W. Uhr. 1971. Cell surface immunoglobulin. II. Isolation and characterization of immunoglobulin from mouse spleen lymphocytes. J. Exp. Med. 134: 242–264.

    Article  PubMed  CAS  Google Scholar 

  114. Marchalonis, J. J., R. E. Cone, and J. L. Atwell. Isolation and partial characterization of lymphocyte surface immunoglobulins J. Exp. Med. 135: 956–971.

  115. Parkhouse, R. M. E., and B. A. Askonas. 1969. Immunoglobulin M biosynthesis. Intracellular accumulation of 7S subunits. Biochem. J. 115: 163–169.

    PubMed  CAS  Google Scholar 

  116. Vitetta, E. S., and J. W. Uhr. 1972. Release of cell surface immunoglobulin by mouse splenic lymphocytes. J. Immunol. 108: 577–579.

    PubMed  CAS  Google Scholar 

  117. Cone, R. E., J. J. Marchalonis, and R. T. Rolley. 1971. Lymphocyte membrane dynamics: metabolic release of cell surface protein by normal and neoplastic lymphocytes. J. Exp. Med. 134: 1373–1384.

    Article  PubMed  CAS  Google Scholar 

  118. Wilson, J. D., G. J. V. Nossal, and H. Lewis. 1972. Metabolic characteristics of lymphocyte surface immunoglobulins. Europ. J. Immunol. 2: 225–232.

    Article  CAS  Google Scholar 

  119. Loor, F., L. Forni, and B. Pernis. 1972. The dynamic state of the lymphocyte membrane. Factors affecting the distribution and turnover of surface immunoglobulins. Europ. J. Immunol. 2: 203–212.

    Article  CAS  Google Scholar 

  120. Lerner, R. A., S. J. McConahey, I. Jansen, and F. J. Dixon. 1972. Synthesis of plasma membrane-associated and secretory immunoglobulin in diploid lymphocytes. J. Exp. Med. 135: 136–149.

    Article  PubMed  CAS  Google Scholar 

  121. Warren, L., and M. C. Glick. 1968. Membranes of animal cells. II. The metabolism and turnover of the surface membrane. J. Cell Biol. 37: 729–746.

    Article  PubMed  CAS  Google Scholar 

  122. Parkhouse, R. M. E. 1973. Assembly and secretion of immunoglobulin M (IgM) by plasma cells and lymphocytes. Transplant. Rev. 14: 131–144.

    PubMed  CAS  Google Scholar 

  123. Roelants, G. E., L. Forni, and B. Pernis. 1973. Blocking and redistribution (“capping”) of antigen receptors on T and B lymphocytes by anti-immunoglobulin antibody. J. Exp. Med. 137: 1060–1077.

    Article  PubMed  CAS  Google Scholar 

  124. Rabellino, E., S. Colom, H. M. Grey, and E. R. Unanue. 1971. Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation. J. Exp. Med. 133: 156–167.

    Article  PubMed  CAS  Google Scholar 

  125. Vitetta, E. S., C. Bianco, V. Nussenzweig, and J. W. Uhr. 1972. Cell surface immunoglobulin. IV. Distribution among thymocytes, bone marrow cells and their derived populations. J. Exp. Med. 136: 81–93.

    Article  PubMed  CAS  Google Scholar 

  126. Grey, H. M., R. T. Kubo, and J. C. Cerottini. 1972. Thymus-derived (T) cell immunoglobulins. Presence of a receptor site for IgG and absence of large amounts of “buried” Ig determinants on T cells. J. Exp. Med. 136: 1323–1328.

    Article  PubMed  CAS  Google Scholar 

  127. Feldman, M., R. E. Cone, and J. J. Marchalonis. 1973. Cell interactions in the immune responsein vitro. VI. Mediation by T cell surface monomeric IgM. Cell Immunol. 9: 1–11.

    Article  Google Scholar 

  128. Cone, R. F., M. Feldman, J. J. Marchalonis, and G. J. V. Nossal. 1973. Cytophilic properties of surface immunoglobulin of thymus-derived lymphocytes. Immunology 26: 49–60.

    Google Scholar 

  129. DuPasquier, L., N. Weiss, and F. Loor. 1972. Direct evidence for immunoglobulins on the surface of thymus lymphocytes of amphibian larvae. Eur. J. Immunol. 2: 366–370.

    Article  CAS  Google Scholar 

  130. Mitchison, N. A. 1969. In: M. Landy and W. Braun (Ed.),Immunological Tolerance. Academic Press, New York, p. 115.

    Google Scholar 

  131. Möller, G. (Ed.), 1974.β 2-microglobulin and HL-A antigen. Transplant. Rev. 21:

  132. Cresswell, P., M. J. Turner, and J. L. Strominger. 1973. Papain-solubilized HL-A antigens from cultured human lymphocytes contain two peptide fragments. Proc. Natl. Acad. Sci. U.S.A. 70: 1603–1607.

    Article  PubMed  CAS  Google Scholar 

  133. Tanigaki, N., M. Katagiri, K. Nakamuro, V. P. Kreiter, and D. Pressman. 1973. A structural component of papain solubilized HL-A antigen molecules. Fed. Proc. 32: 1017.

    Google Scholar 

  134. Springer, T., and J. L. Strominger. 1973. Detergent solubilized HL-A antigen from cultured human lymphocytes. Fed. Proc. 32: 1018.

    Google Scholar 

  135. Rask, L., L. Östberg, B. Lindblom, Y. Fernstedt, and P. A. Peterson. 1974. The subunit structure of transplantation antigens. Transplant. Rev. 21: 85–105.

    PubMed  CAS  Google Scholar 

  136. Strominger, J. L., P. Cresswell, H. Grey, R. E. Humphreys, D. Mann, J. McCune, P. Parham, R. Robb, A. R. Sanderson, T. A. Springer, C. Terhorst, and M. J. Turner. 1974. The immunoglobulin-like structure of human histocompatibility antigens. Transplant. Rev. 21: 126–143.

    PubMed  CAS  Google Scholar 

  137. Edelman, G. M. 1970. The covalent structure of a human γG immunoglobulin. XI. Functional implications. Biochemistry 9: 3197–3205.

    Article  PubMed  CAS  Google Scholar 

  138. Tanigaki, N., and D. Pressman. 1974. The basic structure and the antigenic characteristics of HL-A antigens. Transplant. Rev. 21: 15–34.

    PubMed  CAS  Google Scholar 

  139. Smithies, O., and M. D. Poulik. 1972. Initiation of protein synthesis at an unusual position in an immunoglobulin gene? Science 175: 187–189.

    Article  PubMed  CAS  Google Scholar 

  140. Nakamuro, K., N. Tanigaki, and D. Pressman. 1973. Multiple common properties of humanβ 2-microglobulin and the common portion fragment derived from HL-A antigen molecules. Proc. Natl. Acad. Sci. U.S.A. 70: 2863–2685.

    Article  PubMed  CAS  Google Scholar 

  141. Peterson, P. A., L. Rask, and J. B. Lindblom. 1974. Highly purified papain-solubilized HL-A antigens containβ 2-microglobulin. Proc. Natl. Acad. Sci. U.S.A. 71: 35–39.

    Article  PubMed  CAS  Google Scholar 

  142. Cresswell, P., T. Springer, J. L. Strominger, M. J. Turner, H. M. Grey, and R. T. Kubo. 1974. Immunological identity of the small subunit of HL-A antigens andβ 2-microglobulin and its turnover on the cell membrane. Proc. Natl. Acad. Sci. U.S.A. 71: 2123–2127.

    Article  PubMed  CAS  Google Scholar 

  143. Berggård, I., and A. G. Bearn. 1968. Isolation and properties of a low molecular weightβ 2-globulin occurring in human biological fluids. J. Biol. Chem. 243: 4095–4103.

    PubMed  Google Scholar 

  144. Evrin, P.-E., P. A. Peterson, L. Wide, and I. Berggård. 1971. Radioimmunoassay ofβ 2-microglobulin in human biological fluids. Scand. J. Clin. Lab. Invest. 28: 439–443.

    Article  PubMed  CAS  Google Scholar 

  145. Evrin, P.-E., and L. Wigbell, 1972. The serum levels and urinary excretion ofβ 2-microglobulin in apparently healthy subjects. Scand. J. Clin. Lab. Invest. 29: 69–74.

    Article  PubMed  CAS  Google Scholar 

  146. Cunningham, B. A., J. L. Wang, I. Berggård, and P. A. Peterson. 1973. The complete amino acid sequence ofβ 2-microglobulin. Biochemistry 12: 4811–4822.

    Article  PubMed  CAS  Google Scholar 

  147. Gall, W. E., and G. M. Edelman. 1970. The covalent structure of a human γG-immunoglobulin. X. Intrachain disulfide bonds. Biochemistry 9: 3188–3196.

    Article  PubMed  CAS  Google Scholar 

  148. Cunningham, B. A., and I. Berggård. 1974. Structure, evolution and significance ofβ 2-microglobulin. Transplant. Rev. 21: 3–14.

    PubMed  CAS  Google Scholar 

  149. Edelman, G. M., B. A. Cunningham, W. E. Gall, P. D. Gottlieb, U. Rutishauser, and M. J. Waxdal. 1969. The covalent structure of an entire γG-immunoglobulin molecule. Proc. Natl. Acad. Sci. U.S.A. 63: 78–85.

    Article  PubMed  CAS  Google Scholar 

  150. Karlsson, F. A. 1974. Physical-chemical properties ofβ 2-microglobulin. Immunochemistry. 11: 111–114.

    Article  PubMed  CAS  Google Scholar 

  151. Peterson, P. A., B. A. Cunningham, I. Berggård, and G. M. Edelman. 1972.β 2-microglobulin — a free immunoglobulin domain. Proc. Natl. Acad. Sci. U.S.A. 69: 1697–1701.

    Article  PubMed  CAS  Google Scholar 

  152. Yasmeen, D., J. R. Ellerson, K. J. Dorrington, and R. H. Painter. 1973. Evidence for the domain hypothesis: location of the site of cytophilic activity toward guinea pig macrophages in the CH3 homology region of human immunoglobulin G. J. Immunol. 110: 1706–1709.

    PubMed  CAS  Google Scholar 

  153. Nilsson, K., P.-E. Evrin, I. Berggård and J. Pantern. 1973. Involvement of lymphoid and non-lymphoid cells in the production ofβ 2-microglobulin — a homologue of the constant domains of IgG Nature [New Biol.] 244: 44–45.

    CAS  Google Scholar 

  154. Hütteroth, T. H., H. Cleve, S. D. Litwin, and M. D. Poulik. 1973. The relationship betweenβ 2-microglobulin and immunoglobulin in cultured human lymphoid cell lines. J. Exp. Med. 137: 838–843.

    Article  PubMed  Google Scholar 

  155. Bernier, G. M., and M. W. Fanger, 1972. Synthesis ofβ 2-microglobulin by stimulated lymphocytes. J. Immunol. 109: 407–409.

    PubMed  CAS  Google Scholar 

  156. Evrin, P. E., and H. Pentoft. 1973.β 2-microglobulin in human blood cells. J. Immunol. 111: 1147–1154.

    PubMed  CAS  Google Scholar 

  157. Bismuth, A., C. Neauport-Sautes, F. M. Kourilsky, Y. Manuel, and T. Greenland. 1973. Association entre les antigènes HL-A et laβ 2-microglobuline détectée par immunofluorescence sur la membrane des lymphocytes humains. C. R. Acad. Sci. (Paris). 277: 2845–2848.

    CAS  Google Scholar 

  158. Poulik, M. D., M. Bernoco, D. Bernoco, and R. Ceppellini. 1973. Aggregation of HL-A antigens at the lymphocyte surface induced by antiserum toβ 2-microglobulin. Science 182: 1352–1355.

    Article  PubMed  CAS  Google Scholar 

  159. Solheim, B. G., and E. Thorsby. 1974.β 2-microglobulin. Part of the HL-A molecule in the cell membrane. Tissue Antigens, 4: 83–94.

    Article  PubMed  CAS  Google Scholar 

  160. Neauport-Sautes, C., A. Bismuth, F. M. Kourilsky, and Y. Manuel. 1974. Relationship between HL-A antigens andβ 2-microglobulin as studied by immunofluorescence on the lymphocyte membrane. J. Exp. Med. 139: 957–968.

    Article  PubMed  CAS  Google Scholar 

  161. Östberg, L., J. B. Lindblom and P. A. Peterson. 1974. Subunit structure, of the HL-A antigens on the cell surface. Nature 249: 463–465.

    Article  Google Scholar 

  162. Solheim, B. G. 1974. Association between theβ 2m/HL-A molecule and membrane structures responsible for lymphocyte activation. Transplant. Rev. 21: 35–52.

    PubMed  CAS  Google Scholar 

  163. Nilsson, K., P.-E. Evrin, K. I. Welsh, 1974. Production ofβ 2-microglobulin by normal and malignant human cell lines and peripheral lymphocytes. Transplant. Rev. 21: 53–84.

    PubMed  CAS  Google Scholar 

  164. Kissmeyer-Nielsen, F., and E. Thorsby. 1970. Transplantation antigens. Transplant. Rev. 4: 72–85.

    Google Scholar 

  165. Cunningham, B. A., and I. Berggård. 1974. Structure, evolution and significance ofβ 2-microglobulin. Transplant. Rev. 21: 3–14.

    PubMed  CAS  Google Scholar 

  166. Gally, J. A., and G. M. Edelman. 1972. The genetic control of immunoglobulin synthesis. Ann. Rev. Genetics 6: 1–46.

    Article  CAS  Google Scholar 

  167. Crumpton, M. J., and D. Snary. 1974. Preparation and properties of lymphocyte plasma membrane. Contemp. Top. Mol. Immunol. 3: 27–56.

    PubMed  CAS  Google Scholar 

  168. Ragland, W. L., J. L. Pace, and R. L. Doak, 1973. Plasma membranes of bursal, thymic and circulating lymphocytes have unique proteins. Biochem. Biophys. Res. Commun. 50: 118–126.

    Article  PubMed  CAS  Google Scholar 

  169. Hayman, M. J., and M. J. Crumpton. 1972. Isolation of glycoproteins from pig lymphocyte plasma membrane using Lens culinaris phytohemagglutinin. Biochem. Biophys. Res. Commun. 47: 923–930.

    Article  PubMed  CAS  Google Scholar 

  170. Snary, D., P. Goodfellow, M. J. Hayman, W. F. Bodmer, and M. J. Crumpton. 1974. Subcellular separation and molecular nature of human histocompatibility antigens HL-A. Nature 247: 457–461.

    Article  PubMed  CAS  Google Scholar 

  171. Mandel, T. E. 1972. Intramembraneous marker in T lymphocytes. Nature [New Biol.] 239: 112–114.

    CAS  Google Scholar 

  172. Loor, F. 1973. Lymphocyte membrane particle redistribution induced by a mitogenic-capping dose of the phytohemagglutinin of Phaseolus vulgaris. Eur. J. Immunol. 3: 112–116.

    Article  PubMed  CAS  Google Scholar 

  173. Lerner, R. A., F. J. Dixon. 1973. The human lymphocyte as an experimental animal. Sci. Am. 228: 82–91.

    Article  PubMed  CAS  Google Scholar 

  174. Juliano, R., J. Ciszkowski, D. Waite, and E. Mayhew. 1972. RNA associated with plasma membranes of Ehrlich ascites carcinoma cells. FEBS Lett. 22: 27–30.

    Article  PubMed  CAS  Google Scholar 

  175. Wallach, D. F. H., and P. S. Lin. 1973. A critical evaluation of plasma membrane fractionation. Biochim. Biophys. Acta. 300: 211–254.

    PubMed  CAS  Google Scholar 

  176. Moore, G. E., and L. Woods. 1972. Isoantigens of cultured human lymphoid cells. Transplant. 13: 155–159.

    Article  CAS  Google Scholar 

  177. Sullivan, A. K., and L. M. Jerry. 1975. (Manuscript in preparation.)

  178. Sullivan, A. K., L. M. Jerry, G. Rowden, M. G. Lewis, R. Pitrele, T. Law, L. S. Adams, and H. L. Thi. 1976. Fetal Antigens on the Surface of Human Lymphoid Cells. (Submitted for publication).

  179. Heishko, A., P. Mamont, R. Shields, and G. M. Tompkins. 1971. Pleiotypic response. Nature 232: 206–211.

    Google Scholar 

  180. Pardee, A. B. 1971. The surface membrane as a regulator of animal cell division. In Vitro 1: 95–104.

    Article  Google Scholar 

  181. Möller, G. (Ed.), 1972. Lymphocyte activation by mitogens. Transplant. Rev. Vol 11.

  182. Ada, G. L. 1970. Antigen binding cells in tolerance and immunity. Transplant. Rev. 5: 105–129.

    PubMed  CAS  Google Scholar 

  183. Janossy, G., M. F. Greaves, M. J. Doenhoff, and J. Snajdr. 1973. Lymphocyte activation. V. Quantitation of the proliferative responses to mitogens using defined T and B cell populations. Clin. Exp. Immunol. 14: 581–596.

    PubMed  CAS  Google Scholar 

  184. Greaves, M. F., and G. Janossy. 1972. Elicitation of selective T and B lymphocyte responses by cell surface binding ligands. Transplant. Rev. 11: 87–130.

    PubMed  CAS  Google Scholar 

  185. Andersson, J., O. Sjöberg, and G. Möller. 1972. Mitogens as probes for immunocyte activation and cellular coöperation. Transplant. Rev. 11: 131–177.

    PubMed  CAS  Google Scholar 

  186. Andersson, J., G. M. Edelman, G. Möller, and O. Sjöberg. 1972. Activation of B lymphocytes by locally concentrated concanavalin A. Eur. J. Immunol. 2: 233–235.

    Article  PubMed  CAS  Google Scholar 

  187. Rodbell, M., M. J. Krams, S. L. Pohl, and L. Firnbaumer. 1971. The glucagon-sensitive adenylcyclase system in plasma membranes of rat liver. J. Biol. Chem. 246: 1861–1871.

    PubMed  CAS  Google Scholar 

  188. Inbar, M., H. Ben-Basset, and L. Sachs. 1973. Temperature-sensitive activity on the surface membrane in the activation of lymphocytes by lectins. Exp. Cell Res. 76: 143–151.

    Article  PubMed  CAS  Google Scholar 

  189. Gunther, G. R., J. L. Wang, I. Yahara, B. A. Cunningham, and G. M. Edelman. 1973. Concanavalin A derivatives with altered biological activities. Proc. Natl. Acad. Sci. U.S.A. 70: 1012–1016.

    Article  PubMed  CAS  Google Scholar 

  190. Nicolson, G. 1974. The interaction of lectins with animal cell surfaces. Int. Rev. Cytol. 39: 89–190.

    Article  PubMed  CAS  Google Scholar 

  191. Sela, B., J. L. Wang, and G. M. Edelman. 1975. Antibodies reactive with cell surface carbohydrates. Proc. Natl. Acad. Sci. U.S.A. 72: 1127–1131.

    Article  PubMed  CAS  Google Scholar 

  192. Novogrodsky, A., and E. Katchalski. 1973. Induction of lymphocyte transformation by sequential treatment with neuraminidase and galactose oxidase. Proc. Natl. Acad. Sci. U.S.A. 70: 1824–1827.

    Article  PubMed  CAS  Google Scholar 

  193. Kornfeld, R., and S. Kornfeld. 1970. The structure of a phytohemagglutinin receptor site from human erythrocytes. J. Biol. Chem. 245: 2536–2545.

    PubMed  CAS  Google Scholar 

  194. Hayman, M. J., and M. J. Crumpton. 1972. Isolation of glycoproteins from pig lymphocyte plasma membrane usingLens culinaris phytohemagglutinin. Biochem. Biophys. Res. Commun. 47: 923–930.

    Article  PubMed  CAS  Google Scholar 

  195. Henkart, P. A., and R. I. Fisher. 1975. Characterization of the lymphocyte surface receptors for Con A and PHA. J. Immunol. 114: 710–714.

    PubMed  CAS  Google Scholar 

  196. Möller, G., J. Andersson, H. Pohlit, and O. Sjöberg. 1973. Quantitation of the number of mitogen molecules activating DNA synthesis in T and B lymphocytes. Clin. Exp. Immunol. 13: 89–99.

    PubMed  Google Scholar 

  197. Melchers, F., and J. Andersson. 1973. Synthesis, surface deposition and secretion of immunoglobulin M in bone marrow-derived lymphocytes before and after mitogenic stimulation. Transplant. Rev. 14: 76–130.

    PubMed  CAS  Google Scholar 

  198. Möller, G. (Ed.), 1975. Concepts of B Lymphocyte Activation. Transplant. Rev. Vol. 23.

  199. Diener, E., and M. Feldmann. 1972. Relationship between antigen and antibody-induced suppression of immunity. Transplant. Rev. 8: 76–103.

    PubMed  CAS  Google Scholar 

  200. Coutinho, A., and G. Möller. 1973. B cell mitogenic properties of thymus-independent antigens. Nature [New Biol.] 245: 12–14.

    CAS  Google Scholar 

  201. Feldmann, M., R. E. Cone, and J. J. Marchalonis. 1973. Cell interactions in the immune responsein vitro. VI. Mediation by T cell surface monomer IgM. Cell. Immunol. 9: 1–11.

    Article  PubMed  CAS  Google Scholar 

  202. Feldmann, M., J. G. Howard, and C. Desaymard. 1975. Role of antigen structure in the discrimination between tolerance and immunity by B cells. Transplant. Rev. 23: 78–97.

    PubMed  CAS  Google Scholar 

  203. Coutinho, A., and G. Möller. 1974. Editorial: Immune activation of B cells: evidence for one non-specific triggering signal not delivered by the Ig receptors. Scand. J. Immunol. 3: 133–146.

    Article  PubMed  CAS  Google Scholar 

  204. Möller, G. 1975. One non-specific signal triggers B lymphocytes. Transplant. Rev. 23: 126–137.

    PubMed  Google Scholar 

  205. Countinho, A. 1975. The theory of the “One Nonspecific Signal” model for B cell activation. Transplant. Rev. 23: 49–65.

    Google Scholar 

  206. Bretscher, P., and M. Cohn. 1970. A theory of self-nonself discrimination. Science. 1969: 1042–1049.

    Article  Google Scholar 

  207. Cohn, M., and B. Blomberg. 1975. The self-nonself discrimination: a one- or two-signal mechanism? Scand. J. Immunol. 4: 1–24.

    Article  PubMed  CAS  Google Scholar 

  208. Bretscher, P. A. 1975. The two signal model for B cell induction. Transplant. Rev. 23: 37–48.

    PubMed  CAS  Google Scholar 

  209. Dukor, P., and K.-U. Hartmann. 1973. Hypothesis. Bound C3 as the second signal for B cell activation. Cell Immunol. 7: 349–356.

    Article  PubMed  CAS  Google Scholar 

  210. Hartmann, K.-U. 1975. Possible involvement of C3 during stimulation of B lymphocytes. Transplant. Rev. 23: 98–104.

    PubMed  CAS  Google Scholar 

  211. Katz, D. H., T. Hamaoka, M. E. Dorf, and B. Benacerraf. 1973. Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene. J. Exp. Med. 138: 734–739.

    Article  PubMed  CAS  Google Scholar 

  212. Katz, D. N., T. Hamaoka, M. E. Dorf, and B. Benacerraf. 1973. Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiological lymphocyte interaction. Proc. Natl. Acad. Sci. U.S.A. 70: 2624–2628.

    Article  PubMed  CAS  Google Scholar 

  213. Taussig, M. J., E. Mozes, and R. Isac. 1974. Antigen-specific thymus cell factors in the genetic control of the immune response to poly-(tyrosyl, glutamyl)-poly-D,L-alanyl-poly-lysyl. J. Exp. Med. 140: 301–312.

    Article  PubMed  CAS  Google Scholar 

  214. Katz, D. H., and B. Benacerraf. 1974. The function and interrelationship of T cell receptors, Ir genes and other histocompatibility gene products. Transplant. Rev. 22: 175–195.

    Google Scholar 

  215. Shevach, E. M., L. Lee, and S. Z. Ben-Sasson. 1975. Genetic control of macrophage-T lymphocyte interaction. In: A. Rosenthal (Ed.),Immune Recognition. Proceedings of the Ninth Leucocyte Culture Conference. Academic Press, New York, pp 627–649.

    Google Scholar 

  216. Sachs, D. H., and H. B. Dickler. 1975. The possible role of I region determined cell surface molecules in the regulation of immune responses. Transplant. Rev. 23: 159–175.

    PubMed  CAS  Google Scholar 

  217. Hadden, J. W., E. M. Hadden, M. K. Haddox, and N. D. Goldberg. 1972. Guanosine. 3′, 5′-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 69: 3024–3027.

    Article  PubMed  CAS  Google Scholar 

  218. Whitfield, J. F., J. P. MacManus, A. L. Boynton, D. J. Gillan, and R. J. Isaacs. 1974. Concanavalin A and the initiation of thymic lymphoblast DNA synthesis and proliferation by a calcium-dependent increase in cyclic GMP level. J. Cell. Physiol. 83: 151–156.

    Article  Google Scholar 

  219. Watson, J. 1975. The influence of intracellular levels of cyclic nucleotides on cell proliferation and the induction of antibody synthesis. J. Exp. Med. 141: 97–111.

    Article  PubMed  CAS  Google Scholar 

  220. Weinstein, Y., D. A. Chambers, H. R. Bourne, and K. L. Melmon. 1974. Cyclic GMP stimulates nucleic acid synthesis. Nature. 251: 352–353.

    Article  PubMed  CAS  Google Scholar 

  221. Watson, J. 1975. Cyclic nucleotides as intracellular mediators of B cell activation. Transplant. Rev. 23: 223–249.

    PubMed  CAS  Google Scholar 

  222. Parker, C. W., J. W. Smith, and A. L. Steiner. 1971. Early effects of phytohemagglutinin on lymphocyte cyclic AMP levels. Int. Arch. Allergy Appl. Immunol. 41: 40–46.

    PubMed  CAS  Google Scholar 

  223. Webb, D. R., D. P. Stites, J. D. Perlman, D. Luong, and H. H. Fudenberg. 1973. Lymphocyte activation: the dualistic effect of cAMP. Biochem. Biophys. Res. Comm. 53: 1002–1008.

    Article  PubMed  CAS  Google Scholar 

  224. Krishmaraj, R., and G. P. Talwar. 1973. Role of cyclic cAMP in mitogen induced transformation of human peripheral leukocytes. J. Immunol. 111: 1010–1017.

    Google Scholar 

  225. Parker, C. W. 1975. Possible mechanisms of lymphocyte activation. In: A. S. Rosenthal (Ed.),Immune Recognition. Proceedings of the Ninth Leucocyte Culture Conference, Academic Press, New York, pp. 331–336.

    Google Scholar 

  226. Haddon, J. W., E. M. Haddon, M. K. Haddox, and N. D. Goldberg. 1972. Guanosine 3′, 5′-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 69: 3024–3027.

    Article  Google Scholar 

  227. DeRubertis, F., T. Zeuser, W. Adler, and T. Hudson. 1974. Role of cyclic adenosine 3′, 5′-monophosphate in lymphocyte mitogenesis. J. Immunol. 113: 151–161.

    PubMed  CAS  Google Scholar 

  228. Watson, J. 1975. The influence of intracellular levels of cyclic nucleotides on cell proliferation and the induction of antibody synthesis. J. Exp. Med. 141: 97–111.

    Article  PubMed  CAS  Google Scholar 

  229. DeRubertis, F. R., W. H. Adler, T. V. Zeuser, and T. Hudson. 1974. Role of cyclic adenosine 3′,5′-monophosphate in lymphocyte mitogenesis. J. Immunol. 113: 151–61.

    PubMed  CAS  Google Scholar 

  230. Watson, J. R., R. Epstein, and M. Cohn. 1973. Cyclic nucleotides as intracellular mediators of the expression of antigen-sensitive cells. Nature 246: 405–409.

    Article  PubMed  CAS  Google Scholar 

  231. Ishizuka, M., M. Gafni, and W. Braun. 1970. Cyclic AMP effects on antibody formation and their similarities to hormone-mediated events. Proc. Soc. Exp. Biol. Med. 134: 963–967.

    PubMed  CAS  Google Scholar 

  232. Rudland, P. S., M. Seeley, and W. Seifert. 1974. Cyclic GMP and cyclic AMP levels in normal and transformed fibroblasts. Nature 251: 417–420.

    Article  PubMed  CAS  Google Scholar 

  233. Kram, R., and G. M. Tompkins. 1973. Pleiotypic control by cyclic AMP: interaction with cyclic GMP and possible role of microtubules. Proc. Natl. Acad. Sci. 70: 1659–1663.

    Article  PubMed  CAS  Google Scholar 

  234. Haddon, J. W., E. M. Johnson, E. M. Hadden, R. G. Coffey, and L. D. Johnson. 1975. Cyclic GMP and lymphocyte activation. In: A. Rosenthal (Ed.),Immune Recognition. Proceedings of the Ninth Leucocyte Culture Conference. Academic Press, New York, pp. 359–389.

    Google Scholar 

  235. Wimhurst, J., and K. L. Manchester. 1970. Role of bivalent cations in the control of enzymes involved in gluconeogenesis. FEBS Letters 10: 33–37.

    Article  PubMed  CAS  Google Scholar 

  236. Singer, S. J. 1974. Molecular biology of cellular membranes with applications to immunology. Adv. Immunol. 19: 1–66.

    Article  PubMed  CAS  Google Scholar 

  237. Schultz, G., J. G. Hardman, K. Schultz, C. E. Baird, and E. W. Sutherland. 1973. The importance of calcium ions for the regulation of guanosine 3′, 5′-cyclic monophosphate levels. Proc. Natl. Acad. Sci. U.S.A. 70: 3889–3893.

    Article  PubMed  CAS  Google Scholar 

  238. Maino, V. C., N. M. Green, and M. J. Grumpton. 1974. The role of calcium ions in initiating transformation of lymphocytes. Nature 251: 324–327.

    Article  PubMed  CAS  Google Scholar 

  239. Whitfield, J. F., R. H. Rixon, J. P. McManus, and S. D. Balk. 1973. Calcium, cyclic adenosine 3′, 5′-monophosphate, and the control of cell proliferation: a review. In Vitro 8: 257–278.

    Article  PubMed  CAS  Google Scholar 

  240. McManus, J. P., J. F. Whitfield, A. L. Boyton, and R. H. Rixon. 1974. Role of cyclic nucleotides and calcium in the positive control of cell proliferation. Adv. Cyclic Nucleotide Res. 5: in press.

  241. Kaplan, J. G., and M. R. Quastel. 1975. Lymphocyte transformation and cation transport. In: A. Rosenthal (Ed.),Immune Recognition. Proceedings of the Ninth Leucocyte Culture Conference. Academic Press, New York, pp. 391–403.

    Google Scholar 

  242. Barnett, R. E., R. E. Scott, L. T. Furcht, and J. H. Kersey. 1974. Evidence that mitogenic lectins induce changes in lymphocyte membrane fluidity. Nature 249: 465–466.

    Article  PubMed  CAS  Google Scholar 

  243. Cherry, R. J. 1975. Molecular structure and protein mobility in cellular membranes. In: E. F. Walborg, Jr. (Ed.),Cellular Membranes and Tumor Cell Behaviour. Williams and Wilkins, Co., Baltimore, in press.

    Google Scholar 

  244. Resch, K., and E. Ferber. 1975. The role of phospholipids in lymphocyte activation. In: A. Rosenthal (Ed.),Immune Recognition. Proceedings of the Ninth Leucocyte Culture Conference. Academic Press, New York, pp. 281–312.

    Google Scholar 

  245. Singer, S. J., and G. L. Nicolson. 1975. The fluid mosaic model of the structure of cell membranes. Science. 175: 720–731.

    Article  Google Scholar 

  246. Vischer, T. L. 1974. Stimulation of mouse B lymphocytes by trypsin. J. Immunol. 113: 58–62.

    PubMed  CAS  Google Scholar 

  247. Austen, K. F. 1973. A review of immunological, biochemical, and pharmacological factors in the release of chemical mediators from human lung. In: K. F. Austen, L. M. Lichtenstein (Eds.),Asthma. Physiology, Immunopharmacology, and Treatment. Academic Press, New York, pp. 109–119.

    Google Scholar 

  248. Ji, T., and G. L. Nicolson. 1974. Lectin binding and perturbation of the outer surface of the cell membrane induces a transmembrane organizational alteration at the inner surface. Proc. Natl. Acad. Sci. U.S.A. 71: 2212–2216.

    Article  PubMed  CAS  Google Scholar 

  249. Greaves, M. F. 1975. Scratching the surface. In: A. Rosenthal (Ed.),Immune Recognition. Proceedings of the Ninth Leucocyte Culture Conference. Academic Press, New York, pp. 3–19.

    Google Scholar 

  250. Rodbell, M. 1975. Evidence for multi-site transition states of hormone sensitive adenylate cyclose system. In: G. Nicolson, M. Rodbell (Eds.),Cell Surface Receptors. Proceedings of ICN-UCLA Winter Conferences on Molecular and Cellular Biology, in press.

  251. Gunther, G. R., J. L. Wang, I. Yahara, B. A. Cunningham, and G. M. Edelman. 1973. Concanavalin A derivatives with altered biological activities. Proc. Natl. Acad. Sci. U.S.A. 70: 1012–1016.

    Article  PubMed  CAS  Google Scholar 

  252. Wang, J. L., G. R. Gunther, I. Yahara, B. A. Cunningham, and G. M. Edelman. 1975. Receptor-cytoplasmic interactions and lymphocyte activation. In: A. Rosenthal (Ed.),Immune Recognition. Proceedings of the Ninth Leucocyte Culture Conference. Academic Press, New York, pp. 473–489.

    Google Scholar 

  253. Ono, M., and M. Hozumi. 1973. Effect of cytochalasin B on lymphocyte stimulation induced by concanavalin A or periodate. Biochem. Biophys. Res. Commun. 53: 342–349.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Cancer Research Unit and Department of Experimental Medicine, McGill University, H3C-3G1, Montreal, Quebec, Canada

    L. M. Jerry & A. K. Sullivan

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  1. L. M. Jerry
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  2. A. K. Sullivan
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Presented in the formal symposium on Information Transfer in Eukaryotic Cells, at the 26th Annual Meeting of the Tissue Culture Association, Montreal, Quebec, June 2–5, 1975.

Supported by: Medical Research Council of Canada and National Cancer Institute of Canada.

Scholar of the Medical Research Council of Canada.

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Jerry, L.M., Sullivan, A.K. The lymphocyte plasma membrane: Locus of control in the immune response. In Vitro 12, 236–259 (1976). https://doi.org/10.1007/BF02796446

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