Abstract
The bioavailability of trace elements in infant formulas is affected by different physiological and dietetic factors. In vitro methods based on element dialyzability have been proposed to estimate the bioavailability. Infant formulas of the same type but from different manufacturers can differ in the salt used for supplementation and in the contents of other components that can affect mineral bioavailability. The aim of our study is to estimate the dialyzability of iron, zinc, and copper of formulas marketed in Spain, in order to detect possible differences in formulas of the same type coming from different manufacturers. At the same time, the effects of the type of formula, the composition of the protein fraction, and the mineral content on the element dialyzability are also studied. Differences are found in the dialysis percentages of the elements studied in formulas of the same type but from different manufacturers. The formulas giving the highest dialysis percentages for the three considered elements are the hypoallergenic ones based on protein hydrolysates. No differences are observed in formulas having whey or casein as the main protein fraction. Significant correlations are obtained between the element contents and the dialyzability of the elements.
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References
ESPGAN Committee on Nutrition, Guidelines on infant nutrition. I. Recommendations for the composition of an adapted formula,Acta Paediatr. Scand. 262 (Suppl.), 1–20 (1977).
ESPGAN Committee on Nutrition, Guidelines on infant nutrition. II. Recommendations for the composition of a follow-up formula,Acta Paediatr. Scand. 287 (Suppl.), 1–25 (1981).
ESPGAN Committee on Nutrition, Guidelines on infant nutrition—nutrition and feeding of preterm infants,Acta Paediatr. Scand. 336 (Suppl.), 3–14 (1987).
ESPGAN Committee on Nutrition, Comment on the composition of soy protein based infant and follow-up formulas,Acta Paediatr. Scand. 79, 1–13 (1990).
Codex Alimentarius Commission,Codex Standards for Foods for Spedal Dietary Uses Including Foods for Infants and Young Children and Related Code of Hygienic Practice, Joint FAO/WHO Food Standards Programme, FAO, Rome (1982).
Codex Alimentarius Commission,Draft Standards for Follow-up Formula, Joint FAO/WHO Food Standards Programme, FAO, Rome (1987).
ECC, Commission Directive 91/321/EEC of 14 May 1991 on infant formulae and follow-on formulae, No. L 175, 4/7/1991, pp. 35–49 (1991).
B. Lönnerdal, Effects of milk and milk components on calcium, magnesium, and trace element absorption during infancy,Physiol. Rev. 77(3), 643–669 (1997).
C. F. Mills, Dietary interactions involving the trace elements,Annu. Rev. Nutr. 5, 173–193 (1985).
S. Fairweather-Tait, Bioavailability of trace elements,Food Chem. 43, 213–217 (1992).
S. Fairweather-Tait and R. F. Hurrell (compiled by), Bioavailability of minerals and trace elements,Nutr. Res. Rev. 9, 295–324 (1996).
B. S. Naransiga Rao and T. Prabhavathi, An in vitro method for predicting the bioavailability of iron from foods,Am. J. Clin. Nutr. 31, 169–175 (1978).
D. D. Miller, B. R. Schricker, R. R. Rasmussen, and D. V. Campen, An in vitro method for estimation of iron availability from meals,Am. J. Clin. Nutr. 34, 2248–2256 (1981).
H. M. Crews, A. Burrell, and D. J. McWeeny, Preliminary enzymolysis studies on trace element extractability from food,J. Sci. Food Agric. 34, 997–1004 (1983).
T. Hazell and I. T. Johnson, In vitro estimation of iron availability from a range of plant foods; influence of phytate, ascorbate and citrate,Br. J. Nutr. 57, 223–233 (1987).
A. M. Minihane, T. E. Fox, and S. J. Fairweather-Tait, A continuous flow in vitro method to predict bioavailability of Fe from foods, inBIOAVAILABILITY’93, Nutritional, Chemical and Food Processing Implications of Nutrient Availability, Proceedings Part 2, U. Schlemmer, ed., Bundesforschungsanstalt für Ernährung, Karlsruhe, Germany, pp. 175–179 (1993).
M. G. E. Wolters, H. A. W. Schreuder, G. V. D. Heurel, M. J. V. Lonkhuijsen, R. J. J. Hermus, and A. G. J. Voragen, A continuous in vitro method for estimation of the bioavailability of minerals and trace elements in foods: application to breads varying in phytic acid content,Br. J. Nutr. 69, 849–861 (1993).
L. Shen, J. Luten, H. Robberecht, J. Bindels, and H. Deelstra, Modification of an in-vitro method for estimating the bioavailability of zinc and calcium from foods, Z.Lebensm. Unters. Forsch 199, 442–445 (1994).
J. Luten, H. Crews, A. Flynn, P. Van Dael, P. Kastenmayer, R. Hurrell, et al, Interlaboratory trial on the determination of the in vitro dialysability from food,J. Sci. Food Agric. 72, 415–424 (1996).
ICSH: International Committee for Standardization in Hematology, Proposed recommendations for measurement of serum iron in human blood,J. Clin. Pathol. 24, 334–335 (1971).
G. E. P. Box, W. G. Hunter, and J. S. Hunter,Estadística para Investigadores, Editorial Reverté S. A., Barcelona (1988).
P. E. Johnson and G. W. Evans, Relative zinc availability in human breast milk, infant formulas, and cow’s milk,Am. J. Clin. Nutr. 31, 416–21 (1978).
B. Sandström, C. L. Keen, and B. Lönnerdal, An experimental model for studies of zinc bioavailability from milk and infant formulas using extrinsic labeling,Am. J. Clin. Nutr. 38, 420–428 (1983).
C. E. Casey, P. A. Walravens, and M. K. Hambidge, Availability of zinc: loading test with human milk, cow’s milk and infant formulas,Pediatrics 68, 394–396 (1981).
B. Sandström, A. Cederblad, and B. Lönnerdal, Zinc absorption from human milk, cow’s milk and infant formulas,Am. J. Dis. Child. 137, 726–729 (1983).
B. Lönnerdal, A. Cederblad, L. Davidsson, and B. Sandström, The effect of individual components of soy formula and cow’s milk formula on zinc bioavailability,Am. J. Clin. Nutr. 40, 1064–107 (1983).
E. E. Ziegler, R. E. Serfas, R. A. Baillie, and S. E. Nelson, Absorption of zinc (70Zn) from breast milk and from infant formulas,FASEB J. 7, A 201 (abstract) (1993).
B. Lönnerdal, J. G. Bell, A. G. Hendrickx, R. A. Burns, and C. L. Keen, Copper absorption from human milk, cow’s milk and infants formulas using a suckling rat model,Am. J. Clin. Nutr. 42, 836–844 (1985).
R. Hurrell, S. Lynch, T. Trinidad, A. Dassenko, and J. Cook, Iron absorption in humans as influenced by bovine milk proteins,Am J. Clin. Nutr. 49, 546–552 (1989).
B. Lönnerdal B. M. Yuen, and S. Huang, Calcium, iron, zinc, copper and manganese bioavailability from infant formulas and weaning diets assessed in rat pups,Nutr. Res. 14(10), 1535–1548 (1994).
S. Rudloff and B. Lönnerdal, Calcium and zinc retention from protein hydrolysate formulas in suckling rhesus monkeys,Am. J. Dis. Child. 146, 588–591 (1992).
S. M. Lynch and J. J. Strain, Effects on skim milk powder, whey or casein on tissue trace element status and antioxidant enzyme activities in rats fed control and copperdeficient diets,Nutr. Res. 10, 449–460 (1990).
U. M. Saarinen and M. A. Siimes, Iron absorption from infant formula and the optimal level of iron supplementation,Acta Paediatr. Scand. 66, 719–722 (1977).
E. E. Ziegler, R. E. Serfass, S. E. Nelson, R. Figueroa-Colón, B. B. Edwards, R. S. Houk, et al., Effect of low zinc intake on absorption and excretion of zinc by infants studied with70Zn as extrinsic tag,J. Nutr. 119, 1647–1653 (1989).
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García, R., Alegría, A., Barberá, R. et al. Dialyzability of iron, zinc, and copper of different types of infant formulas marketed in Spain. Biol Trace Elem Res 65, 7–17 (1998). https://doi.org/10.1007/BF02784110
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DOI: https://doi.org/10.1007/BF02784110