Skip to main content
Log in

Regulation of circulating leptin in humans

  • Review
  • Published:
Endocrine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Ingalls, A. M., Dickie, M. M., and Snell, G. D. (1950).J. Hered.,41, 317–318.

    PubMed  CAS  Google Scholar 

  2. Coleman, D. L. (1978).Diabetologia 14, 141–148.

    Article  PubMed  CAS  Google Scholar 

  3. Hausberger, F. X. (1959).Anat. Rec. 130, 313.

    Google Scholar 

  4. Coleman, D. L. (1973).Diabetologia 9, 294–298.

    Article  PubMed  CAS  Google Scholar 

  5. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994).Nature 372, 425–432.

    Article  PubMed  CAS  Google Scholar 

  6. Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., and Collins, F. (1995).Science 269, 540–543.

    Article  PubMed  CAS  Google Scholar 

  7. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., and Friedman, J. M. (1995).Science 269, 543–546.

    Article  PubMed  CAS  Google Scholar 

  8. Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., and Burn, P. (1995).Science 269, 546–549.

    Article  PubMed  CAS  Google Scholar 

  9. Maffei, M., Fei, H., Lee, G. H., Dani, C., Leroy, P., Zhang, Y., Proenca, R., Negrel, R., Ailhaud, G., and Friedman, J. M. (1995).Proc. Natl. Acad. Sci. USA 92, 6957–6960.

    Article  PubMed  CAS  Google Scholar 

  10. Masazuki, H., Ogawa, Y., Isse, N., Satoh, N., Okazaki, T., Shigemoto, M., Mori, K., Tamura, N., Hosada, K., Yoshimasa, Y., Jingami, H., Kawada, T., and Nakao, K. (1995).Diabetes 44, 855–858.

    Article  Google Scholar 

  11. MacDougald, O. A., Hwang, C. S., Fan, H., and Lane, M. D., (1995).Proc. Natl. Acad. Sci. USA 92, 9034–9037.

    Article  PubMed  CAS  Google Scholar 

  12. Kolaczynski, J. W., Nyce, M. R., Considine, R. V., Boden, G., Nolan, J. J., Henry, R., Mudaliar, S. R., Olefsky, J., and Caro, J. F. (1996).Diabetes 45, 699–701.

    Article  PubMed  CAS  Google Scholar 

  13. Klein, S., Coppack, S. W., Mohamed-Ali, V., and Landt, M. (1996).Diabetes 45, 984–987.

    Article  PubMed  CAS  Google Scholar 

  14. Weigle, D. S., Bukowski, T. R., Foster, D. C., Holderman, S., Kramer, J. M., Lasser, G., Lofton-Day, C. E., Prunkard, D. E., Raymond, C., and Kujiper, J. L. (1995).J. Clin. Invest. 96, 2065–2070.

    PubMed  CAS  Google Scholar 

  15. Levin, N., Nelson, C., Gurney, A., Vandlen, R., and De Sauvage, F. (1996).Proc. Natl. Acad. Sci. USA 93, 1726–1730.

    Article  PubMed  CAS  Google Scholar 

  16. Chen, H., Charlat, O., Tartaglia, L. A., Woold, E. A., Weng, X., Ellis, S. J., Lakey, J. D., Culpepper, J., Moore, K. J., Breitbart, R., Duyk, G. M., Tepper, R. I. and Morgenstern, J. P. (1996).Cell 84, 491–495.

    Article  PubMed  CAS  Google Scholar 

  17. Lee, G. H., Proenca, R., Montez, J. M., Carrol, K. M., Proenca, R., Montez, J. M., Darvishzadeh, J. G., Lee, J. I., and Friedman, J. M. (1996).Nature 279, 632–635.

    Article  Google Scholar 

  18. Tartaglia, L. A., Dembski, M., Weng, X. U., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Woolf, E. A., Monroe, C. A., and Tepper, R. I. (1995).Cell 83, 1263–1271.

    Article  PubMed  CAS  Google Scholar 

  19. Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte Jr, D., Woods, S. C., Seeley, R. J., and Weigle, D. S. (1996).Diabetes 45, 531–535.

    Article  PubMed  CAS  Google Scholar 

  20. Erickson, J. C., Clegg, K. E., and Palmiter, R. D. (1996).Nature 381, 415–418.

    Article  PubMed  CAS  Google Scholar 

  21. Caro, J. F., Sinha, M. K., Kolaczynski, J. W., Zhang, P. L., and Considine, R. V. (1996).Diabetes 45, 1455–1462.

    PubMed  CAS  Google Scholar 

  22. Ma, Z. A., Gingerich, R. L., Santiago, J. V., Klein, S., Smith, H. C., and Landt, M. (1996).Clin. Chem. 42, 942–946.

    PubMed  CAS  Google Scholar 

  23. Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nuce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., and Caro, J. F. (1996).N. Engl. J. Med. 334, 292–295.

    Article  PubMed  CAS  Google Scholar 

  24. McGregor, G. P., Desaga, J. F., Ehlenz, K., Fischer, A., Heese, F., Hegele, A., Lämmer, C., Peiser, C., and Lang, R. E. (1996).Endocrinology 137, 1501–1504.

    Article  PubMed  CAS  Google Scholar 

  25. Houseknecht, K. L., Mantzoros, C. S., Kuliawat, R., Hadro, E., Flier, J. S., and Kahn, B. B. (1996).Diabetes 45, 1638–1643.

    Article  PubMed  CAS  Google Scholar 

  26. Sinha, M. K., Opentanova, I., Ohannesian, J. P., Kolaczynski, J. E., Heiman, M. L., Hale, J., Becker, G. W., Bowsher, R. R., Stephens, T. W., and Caro, J. F. (1996).J. Clin. Invest. 98, 1277–1282.

    PubMed  CAS  Google Scholar 

  27. Bonner, J. C., and Brody, A. R. (1995).Am. J. Physiol. 12, L869-L878.

    Google Scholar 

  28. Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganatahan, S., Kern, P. A., and Friedman, J. M. (1995).Nature Med. 1, 1155–1161.

    Article  PubMed  CAS  Google Scholar 

  29. Dagogo-Jack, S., Fanelli, C., Paramore, D., Brothers, J., and Landt, M. (1996).Diabetes 45, 695–698.

    Article  PubMed  CAS  Google Scholar 

  30. Dua, A., Hennes, M. I., Joffmann, R. G., Maas, D. L., Krakower, G. R., Sonnenberg, G. E., and Kissebah, H. (1996).Diabetes 45, 1635–1637.

    Article  PubMed  CAS  Google Scholar 

  31. Larsson, H., Elmståhl, S., and Ahrén, B. (1996).Diabetes 45, 1580–1584

    Article  PubMed  CAS  Google Scholar 

  32. Havel, P. J., Kasim-Karakas, S., Mueller, W., Johnson, P. R., Gingerich, R. L., and Stern, J. S. (1996).J. Clin. Endocrinol. Metabol. 81, 4406–4413.

    Article  CAS  Google Scholar 

  33. Kissebah, A., Vydelingum, N., Murray, R., Evans, D., Hartz, A., Kalkhoff, R. K., and Adams, R. W. (1982).J. Clin. Endocrinol. Metab. 54, 254–260.

    Article  PubMed  CAS  Google Scholar 

  34. Kissebah, A. H., and Krakower, G. R. (1994).Physiol. Rev. 74, 761–811.

    PubMed  CAS  Google Scholar 

  35. Pratley, R. E., Tataranni, P. A., Snitker, S., Bogardus, C., and Ravussin, E. (1996).Obes. Res. 4, 25S.

    Google Scholar 

  36. Kolaczynski, J. W., Considine, R. V., Ohannesian, J., Marco, C., Opentanova, I., Nyce, M. R., Myint, M., and Caro, J. F. (1996).Diabetes,45, 1511–1515.

    Article  PubMed  CAS  Google Scholar 

  37. Havel, P. J., Månsson, S., Gingerich, R. L., and Ahrén, B. (1997).Am. J. Physiol. 273, R113–120.

    PubMed  Google Scholar 

  38. Kolaczynski, J. W., Ohannesian, J., Considine, R. V., Marco, C. C., and Caro, J. F. (1996).J. Clin. Endocrinol. Metab. 81, 4162–4165.

    Article  PubMed  CAS  Google Scholar 

  39. Hamilton, B. S., Paglia, D., Kwan, Y. M., and Deitel, M. (1995).Nature Med. 1, 953–956.

    Article  PubMed  CAS  Google Scholar 

  40. Lönnquist, F., Arner, P., Nordford, L., and Schalling, M. (1995).Nature Med. 1, 950–953.

    Article  Google Scholar 

  41. Hamann, A., and Matthaei, S. (1996).Exp. Clin. Endocrinol. Diabetes,104, 293–300.

    Article  PubMed  CAS  Google Scholar 

  42. Wei, M., Haffner, S. M., and Stern, M. P. (1996).Obes. Res. 4, 44S.

    Google Scholar 

  43. Schwartz, M. W., Peskind, E., Raskin, M., Boyko, E. J., and Porte Jr, D. (1996).Nature Med. 2, 589–593.

    Article  PubMed  CAS  Google Scholar 

  44. Fujioka, K., Patane, J., Manuak, C., and Staten, M. (1996).Obes. Res. 4, 42S.

  45. Frederich, R. C., Löllman, B., Hamann, A., Napolitano-Rosen, A., Kahn, B. B., Lowell, B. B., and Flier, J. S. (1995).J. Clin. Invest. 96, 1658–1663.

    PubMed  CAS  Google Scholar 

  46. Havel, P. J., Kasim-Karakas, S., Dubuc, G. R., Mueller, W., and Phinney, S. D. (1996).Nature Med. 2, 949–950.

    PubMed  CAS  Google Scholar 

  47. Sinha, M. K., Ohannesian, J. P., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Magosin, S., Marco, C., and Caro, J. F. (1996).J. Clin. Invest. 97, 1344–1347.

    PubMed  CAS  Google Scholar 

  48. Robyn, C. (1981).Am. J. Physiol. 241, E355-E363.

    PubMed  Google Scholar 

  49. Weitzman, E. D., Zimmerman, J. C., Czeisler, C. A., and Ronda, J. M., (1983).J. Clin. Endocrinol. Metab. 56, 352–358.

    PubMed  CAS  Google Scholar 

  50. van Coevorden, A., Laurent, E., Decoster, C., van Cauter, E., Kerkhof, M., Meve, P., and Mockel, J. (1989).J. Clin. Endocrinol. Metab. 69, 177–185.

    PubMed  Google Scholar 

  51. Bergman, R. N., Phillips, L. S., and Cobelli, C. (1981).J. Clin. Invest. 68, 1456–1467.

    Article  PubMed  CAS  Google Scholar 

  52. Bogardus, C., Lillioja, S., Mott, D. M., Hollenbeck, C., and Reaven, G. (1985).Am. J. Physiol. 248, E286-E291.

    PubMed  CAS  Google Scholar 

  53. Bonadonna, R. C., and DeFronzo, R. A. (1991).Diabetes Metab. 17, 112–135.

    CAS  Google Scholar 

  54. Olefsky, M., Kolterman, O. G., and Scarlet, J. A. (1982).Am. J. Physiol. 243, E15-E30.

    PubMed  CAS  Google Scholar 

  55. Zunigo-Guajardo, S., Jimenez, J., Angel, A., and Zinman, B. (1986).Metabolism 35, 278–282.

    Article  Google Scholar 

  56. Segal, K. R., Landt, M., and Klein, S. (1996).Diabetes 45, 988–991.

    Article  PubMed  CAS  Google Scholar 

  57. Nolan, J. J., Olefsky, J. M., Nyce, M. R., Considine, R. V., and Caro, J. F. (1996).Diabetes 45, 1276–1278.

    Article  PubMed  CAS  Google Scholar 

  58. Larsson, H., and Ahrén, B. (1996).J. Clin. Endocrinol. Metab. 81, 4428–4432.

    Article  PubMed  CAS  Google Scholar 

  59. De Vos, P., Saladion, R., Auwerx, J., and Staels, B. (1995).J. Biol. Chem. 270, 15,958–15,961.

    Article  Google Scholar 

  60. Kahn, S. E., Prigeon, R. L., McCulloch, D. S. K., Boyko, E. J., Bergman, E. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., Palmer, J. P., and Porte Jr, D. (1993).Diabetes 42, 1663–1672.

    Article  PubMed  CAS  Google Scholar 

  61. Larsson, H., and Ahrén, B. (1996).Diabetologia 39, 1099–1107.

    Article  PubMed  CAS  Google Scholar 

  62. Wabitsch, M., Jensen, P. B., Blum, W. F., Christoffersen, C. T., Englaro, P., Heinze, E., Rascher, W., Teller, W., Tornqvist, H., and Hauner, H. (1996).Diabetes 45, 1435–1438.

    Article  PubMed  CAS  Google Scholar 

  63. Cusin, I., Sainsbury, A., Doyle, P., Rohner-Jeanrenaud, F., and Jeanrenaud, B. (1995).Diabetes 44, 1467–1470.

    Article  PubMed  CAS  Google Scholar 

  64. Saladin, R., De Vos, P., Guerre-Millo, M., Leturque, A., Girard, J., Staels, B., and Auwerx, J. (1995).Nature 377, 527–529.

    Article  PubMed  CAS  Google Scholar 

  65. Kieffer, T. J., Heller, R. S., and Habener, J. F. (1996).Biochem. Biophys. Res. Commun. 224, 522–527.

    Article  PubMed  CAS  Google Scholar 

  66. Malmström, R., Taskinen, M. R., Karonen, S. L., and Yki-Järvinen, H. (1996).Diabetologia 39, 993–996.

    Article  PubMed  Google Scholar 

  67. Utriainen, T., Malmström, R., Mäkimattila, S., and Yki-Järvinen, H. (1996).Diabetes 45, 1364–1366.

    Article  PubMed  CAS  Google Scholar 

  68. Havel, P. J., Aoki, T. T., Grecu, E. O., Stern, J. S., and Kasim-Karakas, S. (1996).Obes. Res. 4, 15S.

    Google Scholar 

  69. Ahrén B., and Larsson, H. (1996).Diabetologia 39, A58.

    Article  Google Scholar 

  70. Porte Jr, D. (1991).Diabetes 40, 166–180.

    Article  PubMed  Google Scholar 

  71. Becker, D. J., Ongemba, L. N., Brichard, V., Henquin, J. C., and Brichard, S. M. (1995).FEBS Lett. 371, 324–328.

    Article  PubMed  CAS  Google Scholar 

  72. Moinat, M., Deng, C., Muzzin, P., Assimacopoulos-Jeannet, F., Seydoux, J., Dulloo, A.G., and Giacobino, J.P. (1995).FEBS Lett. 373, 131–134.

    Article  PubMed  CAS  Google Scholar 

  73. Trayhurn, P., Thomas, M. E. A., Duncan, J. S., and Rayner, D. V. (1995).FEBS Lett. 368, 488–490.

    Article  PubMed  CAS  Google Scholar 

  74. Gettys, T. W., Harkness, P. J., and Watson, P. M. (1996).Endocrinology 137, 4054–4057.

    Article  PubMed  CAS  Google Scholar 

  75. Mizuno, T. M., Bergen, H., Funabashi, T., Kleopoulos, S. P., Zgong, Y. G., Bauman, W. A., and Mobbs, C. V. (1996).Proc. Natl. Acad. Sci. U.S.A. 93, 3434–3438.

    Article  PubMed  CAS  Google Scholar 

  76. Slieker, J. L., Sloop, K. W., Surface, P. L. K., Kriauciunas, A., Laquier, F., Manetta, J., Buevalleskey, J., and Stephens, T. W. (1996).J. Biol. Chem. 271, 5301–5304.

    Article  PubMed  CAS  Google Scholar 

  77. Thompson, M. P. (1996).Biochem. Biophys. Res. Commun. 224, 332–337.

    Article  PubMed  CAS  Google Scholar 

  78. Mantzaros, C., Qu, D., Frederich, R. C., Susulic, V. S., Lowell, B. B., Maratos-Flier, E., and Flier, J. S. (1996).Diabetes 45, 909–914.

    Article  Google Scholar 

  79. Donahoo, W. T., Jensen, D. R., Yost, T. J., and Eckel, R. H. (1996).Obes. Res. 4, 39S.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bo Ahrén.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ahrén, B., Larsson, H., Wilhelmsson, C. et al. Regulation of circulating leptin in humans. Endocr 7, 1–8 (1997). https://doi.org/10.1007/BF02778056

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02778056

Keywords

Navigation