Summary
Exposure of HTC cells to sodium butyrate caused inhibition of growth. The site of growth inhibition was studied by time-lapse cinematography and [3H]thymidine incorporation studies. Evidence is presented that sodiunm butyrate affected the cell cycle at a specific point immediately after mitosis. Inasmuch as it does not modify the interphase duration after its removal, butyrate may be used for HTC synchronization.
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This work was supported by l'Institut Nationale de la Santé et de la Recherche Médicale and la Centre Nationale de la Recherche Scientifique (L. T. and J. K.).
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van Wijk, R., Tichonicky, L. & Kruh, J. Effect of sodium butyrate on the hepatoma cell cycle: Possible use for cell synchronization. In Vitro 17, 859–862 (1981). https://doi.org/10.1007/BF02618280
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DOI: https://doi.org/10.1007/BF02618280