Summary
Nonhuman primates represent an important reservoir for the transmission of new infectious diseases to humans. While several working groups and international agencies have grappled with the ethics of xenotransplantation, the Nuffield Council on Bioethics have recently published a comprehensive and far-reaching series of recommendations that, while not eliminating the infectious disease risks, have nonetheless detailed the major points for concern and have developed a rational approach to minimizing these risks. This report should serve as the blueprint from which to proceed with xenotransplantation.
References
Nuffield Council on Bioethics. (1996)Animal-to-human transplants, the ethics of xenotransplantation.
Institute of Medicine (1996)Xenotransplantation; Science, Ethics and Public Policy. National Academy Press, Washington, D.C.
Department of Health and Human Services (1996) Draft Public Health Service (PHS) guidelines on infectious disease issues in xenotransplantation.Federal Register 61:49920–32.
Reemstma K. (1995) Xenotransplantation: historical perspective.Institute of Laboratory Animal Resources Journal 37:9–12.
Myers G, MacInnes K and Korber B. (1992) The emergence of simian/human immunodeficiency viruses.AIDS Research and Human Retroviruses 8: 373–386.
Allan J (1995) Xenograft transplantation and the infectious disease conundrum.Institute of Laboratory Animal Resources Journal 37:37–48.
Allan J (1996) Xenotransplantation at a crossroads: prevention versus progress.Nature Medicine 2:18–21.
Allan, J S (1996) Xenotransplantation and possible emerging infectious diseases.Molecular Diagnosis 1(3): 1–9.
Chapman L, Folks T, Salomon D, Patterson A, Eggerman T and Noguchi P (1995) Xenotransplantation and xenogeneic infections.New Engl Journal of Medicine 333: 1498–501.
Michaels, M. and Simmons, R. (1994) Xenotransplant-associated zoonoses.Transplantation 57:1–7.
Fishman, J. (1994) Miniature swine as organ donors for man: strategies for prevention of xenotransplantation-associated infections.Xenotransplantation 1: 47–57.
Webster, R. (1993) Influenza, In: Morse S, ed.,Emerging Viruses. Oxford University Press, Oxford 37–45.
Author information
Authors and Affiliations
Additional information
Dr. Allan’s research focuses on simian retroviruses, including simian immunodeficiency viruses (SIV).
Rights and permissions
About this article
Cite this article
Allan, J.S. Public health concerns take center stage in Nuffield Council on Bioethics. Sci Eng Ethics 2, 486–490 (1996). https://doi.org/10.1007/BF02583936
Issue Date:
DOI: https://doi.org/10.1007/BF02583936