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Immobilized lipase reactors for modification of fats and oils—A review

  • Review
  • Published:
Journal of the American Oil Chemists’ Society

Abstract

This review focuses on the use of immobilized lipase technology to effect hydrolysis, ester synthesis, and interesterification reactions. The various immobilization procedures, reactor configurations, and process considerations are all reviewed and discussed.

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References

  1. Werdelmann, B.W., and R.D. Schmid,Fette Seifen Anstrichm. 84:436 (1982).

    Article  CAS  Google Scholar 

  2. Nawar, W.W., inFood Chemistry, edited by O.R. Fennema, Marcel Dekker, Inc., New York, 1985, p. 139.

    Google Scholar 

  3. Aunstrup, K.,Appl. Biochem. Bioeng. 2:27 (1975).

    Google Scholar 

  4. Neidelman, S.L., and J. Geigert,J. Am. Oil Chem. Soc. 61:290 (1984).

    Google Scholar 

  5. Boyce, C.O.L.,Ibid. 61:1750 (1984).

    CAS  Google Scholar 

  6. Posorske, L.H.,Ibid. 61:1758 (1984).

    CAS  Google Scholar 

  7. Ishida, S.,Yushi 37:47 (1984).

    CAS  Google Scholar 

  8. Nielsen, T.,Fette Seifen Anstrichm. 87:15 (1984).

    Article  Google Scholar 

  9. Smith, H.V.,J. Am. Oil Chem. Soc. 62:351 (1985).

    CAS  Google Scholar 

  10. Werdelmann, B.W.,Fette Seifen Anstrichm. 76:1 (1974).

    Article  CAS  Google Scholar 

  11. Stein, W.,Ibid. 84:45 (1982).

    Article  CAS  Google Scholar 

  12. Bindo, J.S., and G.D. Smith,J. Am. Oil Chem. Soc. 58:68A (1981).

    Google Scholar 

  13. Boelhouwer, C., inFuture Sources of Organic Raw Materials, World Conference on Future Sources of Organic Raw Materials, edited by L.E. St. Pierre and G.R. Brown, Pergamon Press, New York, 1980, p. 637.

    Google Scholar 

  14. Pryde, E.H.,J. Am. Oil Chem. Soc. 56:719A (1979).

    Google Scholar 

  15. Klimmek, H.,Chem. Ind. 33:136 (1981).

    Google Scholar 

  16. Anonymous,Chemical Marketing Reporter August 31:7 (1981).

  17. Anonymous,Chemical Age October 3:16 (1980).

  18. Segel, I.H.,Enzyme Kinetics—Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems, John Wiley and Sons, New York, 1975, pp. 5–7.

    Google Scholar 

  19. Creighton, T.E.,Protein—Structures and Molecular Properties, W.H. Freeman and Co., New York, 1984, pp. 419–425.

    Google Scholar 

  20. Walsh, C.,Enzymatic Reaction Mechanisms, W.H. Freeman and Co., New York, 1984, pp. 24–48.

    Google Scholar 

  21. Linfield, W.M., D.J. O'Brien, S. Serota and R.A. Barauskas,J. Am. Oil Chem. Soc. 61:1067 (1984).

    CAS  Google Scholar 

  22. Nisshin Oil Mills Ltd., Japanese Patent No. 7,041,304 (1970).

  23. Nisshin Oil Mills Ltd.,Ibid. Japanese Patent No. 7,116,508 (1971).

  24. Nisshin Oil Mills Ltd.,Ibid. Japanese Patent No. 7,680,305 (1976).

  25. Meito Sangyo Co, KK,Ibid. Japanese Patent No. 7,116,509 (1971).

  26. Meito Sangyo Co. KK,Ibid. Japanese Patent No. 7,928,305 (1979).

  27. Meito Sangyo Co. KK,Ibid. Japanese Patent No. 7,995,607 (1979).

  28. Anonymous,Japan Chem. Week May 14:2 (1981).

  29. Anonymous,Ibid. Japan Chem. Week Feb. 4:1 (1982).

  30. Anonymous,Yushi 34:28 (1981).

  31. Sonntag, N.O.V.,J. Am. Oil Chem. Soc. 56:861A (1979).

    CAS  Google Scholar 

  32. Nielsen, T.,Fette Seifen Anstrichm. 83:507 (1981).

    Article  Google Scholar 

  33. Day, E.A., inFlavor Chemistry, edited by R.F. Gould, American Chemical Society, Washington, D.C., 1966, p. 94.

    Google Scholar 

  34. Dwivedi, B.K.,CRC Crit. Rev. Food Technol. 3:457 (1973).

    Google Scholar 

  35. Nelson, J.H.,J. Am. Oil Chem. Soc. 49:559 (1972).

    CAS  Google Scholar 

  36. Arnold, R.G., K.M. Shahani and B.K. Dwivedi,J. Dairy Sci. 58:1127 (1975).

    Article  CAS  Google Scholar 

  37. Shahani, K.M., R.G. Arnold, A. Kilara, and B.K. Dwivedi,Biotechnol. Bioeng. 18:891 (1976).

    Article  CAS  Google Scholar 

  38. Fox, P.F.,J. Soc. Dairy Technol. 33:118 (1980).

    CAS  Google Scholar 

  39. Kilara, A.,Process Biochem. 20:33 (1985).

    Google Scholar 

  40. Otting H.E., and M&R Dietetic Labs Inc., U.S. Patent No. 1,966,460 (1934).

  41. Otting, H.E., and M&R Dietetic Labs Inc.,Ibid. U.S. Patent No. 2,169,278 (1939).

  42. Farnham, M.G., and Dairyland Food Laboratories, Inc.,Ibid. U.S. Patent No. 2,531,329 (1950).

  43. Farnham, M.G., and Dairyland Food Laboratories Inc.,Ibid. U.S. Patent No. 2,794,743 (1957).

  44. Kraftco Corp., British Patent No. 1,240,345 (1971).

  45. Roberts, M.J., and Kraftco Corp., Canadian Patent No. 911,248 (1971).

  46. Roberts, M.J., and Kraftco Corp.,Ibid. Canadian Patent No. 911,250 (1971).

  47. Roberts, M.J., and Kraftco Corp., U.S. Patent No. 3,650,768 (1971).

  48. Fukumoto, J., Japanese Patent No. 20,026 (1971).

  49. Anonymous,Technical Bulletin of Lipase APF12-UL8, AMANO International Enzyme Co., Troy, VA, 1985.

  50. Arbige, M.V., P.R. Freund, S.C. Silver and J.T. Zelko,Food Technol. 40:91 (1986).

    CAS  Google Scholar 

  51. Kempf, C.A., J.S. Niedlinger, A.P. Stewart, P.F. Sharp and Golden State Co. Ltd., U.S. Patent No. 2,638,418 (1953).

  52. Tanabe Seiyaku Co. Ltd., Japanese Patent No. 3,187 (1970).

  53. Morton International Inc., British Patent No. 1,251,272 (1971).

  54. Engel, E., J.H. Nelson, C.H. Amundson, A.C. Buhler and Morton-Norwich Products Inc., Canadian Patent No. 912,905 (1971).

  55. Buhler, A.C., E. Engel, J.H. Nelson, C.H. Amundson and Morton-Norwich Products, U.S. Patent No. 3,653,921 (1972).

  56. Pangier, D.J., and Miles Laboratory Inc.,Ibid. U.S. Patent No. 3,469,993 (1969).

  57. Bauman, H.E., J.L. MacMillan, J.A. Stein and Pillsbury Co.,Ibid. No. 2,965,492 (1960).

  58. Knight, S.G.,Ibid. U.S. Patent No. 3,100,153 (1963).

  59. Watts, J.C., and J.H. Nelson,Ibid. U.S. Patent No. 3,190,753 (1965).

  60. Claus, W.S., and Carnation Co.,Ibid. U.S. Patent No. 3,190,753 (1965).

  61. Kraftco Corp., British Patent No. 1,326,516 (1972).

  62. Johnson, J.D., D.L. Southworth and Kraftco Corp., U.S. Patent No. 3,780,182 (1973).

  63. Andres, C.,Food Proc. 41:104 (1980).

    Google Scholar 

  64. Andres, C.,Ibid. 42:62 (1981).

    Google Scholar 

  65. Okumura, S., M. Iwai and Y. Tsujisaka,Biochim. Biophys. Acta 575:156 (1979).

    CAS  Google Scholar 

  66. Iwai, M., S. Okumura and Y. Tsujisaka,Agric. Biol. Chem. 44:2731 (1980).

    CAS  Google Scholar 

  67. Marlot, C., G. Landgrand, C. Triantaphylides and J. Baratti,Biotechnol. Lett. 7:647 (1985).

    Article  CAS  Google Scholar 

  68. Coleman, M.H., and A.R. Macrae, U.S. Patent No. 4,275,081 (1981).

  69. Matsuo, T., N. Sawamura Y. Hashimoto and W. Hashida,Ibid. U.S. Patent No. 4,268,3527 (1981).

  70. Tanaka, T., E. Ono and K. Takinami,Ibid. U.S. Patent No. 4,275,011 (1981).

  71. Macrae, A.R., inBiocatalysts in Organic Syntheses, edited by J. Tramper, H.C. van der Plaas and P. Linko, Elsevier Applied Science Publishers, Amsterdam, 1985, p. 195.

    Google Scholar 

  72. Tanaka, T., E. Ono and K. Takinami, U.S. Patent No. 4,275,011 (1981).

  73. Matsuo, T., N. Sawamura, Y. Hashimoto and W. Hashida,Ibid. U.S. Patent No. 4,420,560 (1983).

  74. Asahi Denka Co., Japanese Patent No. 57,198,798 (1982).

  75. Macrae, A.R.,J. Am. Oil Chem. Soc. 60:291 (1983).

    CAS  Google Scholar 

  76. Asahi Denka Co., Japanese Patent No. 57,111,398 (1982).

  77. Fuji Oil Co.,Ibid. Japanese Patent No. 56,025,643 (1981).

  78. Kilara, A. and K.M. Shahani,C.R.C. Crit. Rev. Food Sci. Nutr. 12:161 (1977).

    Article  Google Scholar 

  79. Karube, I., Y. Yugeta and S. Suzuki,Biotechnol. Bioeng. 19:1493 (1977).

    Article  CAS  Google Scholar 

  80. Kilara, A.,Proc. Biochem. 16:25 (1981).

    CAS  Google Scholar 

  81. Bailey, J.E., and D.F. Ollis,Biochemical Engineering Fundamentals, McGraw-Hill Book Co., New York, 1986, pp. 180–189.

    Google Scholar 

  82. Weetall, H.H.,Food Prod. Dev. 7:46 (1973).

    CAS  Google Scholar 

  83. Melius, P., and B.-C. Wang,Adv. Exp. Med. Biol. 42:339 (1974).

    CAS  Google Scholar 

  84. Lieberman, R.B., and D.F. Ollis,Biotechnol. Bioeng. 17:1401 (1975).

    Article  CAS  Google Scholar 

  85. Kobayashi, T., I. Kato, K. Ohmiya and S. Shimizu,Agric. Biol. Chem. 44:413 (1980).

    CAS  Google Scholar 

  86. Lavayre, J., and J. Baratti,Biotechnol. Bioeng. 24:1007 (1982).

    Article  CAS  Google Scholar 

  87. Patton, J.S., and L. Andersson,FEBS Lett. 86:179 (1978).

    Article  CAS  Google Scholar 

  88. Patton, J.S., P.A. Albertsson, C. Erlanson and B. Borgström,J. Biol. Chem. 253:4195 (1978).

    CAS  Google Scholar 

  89. Kimura, Y., A. Tanaka, K. Sonomoto, T. Nihira and S. Fukui,Eur. J. Appl. Microbiol. Biotechnol. 17:107 (1983).

    Article  CAS  Google Scholar 

  90. Yokozeki, K., S. Yamanaka, K. Takimani, Y. Hirose, A. Tanaka, K. Sonomoto and S. Kukui,Ibid. 14:1 (1982).

    Article  CAS  Google Scholar 

  91. Kilara, A.,Process Biochem. 16:25 (1981).

    CAS  Google Scholar 

  92. Kilara, A., K.M. Shahani and F.W. Wagner,Biotechnol. Bioeng. 19:1703 (1977).

    Article  CAS  Google Scholar 

  93. Tahoun, M.K.,Food Chemistry 22:297 (1986).

    Article  CAS  Google Scholar 

  94. Rakhimov, M.M., N.R. Dzhanbaeva and I.V. Berezin,Doklady Biochem. 229:389 (1977).

    Google Scholar 

  95. Ogiso, T., M. Sugiura and Y. Kato,Chem. Pharm. Bull. 20:2542 (1972).

    CAS  Google Scholar 

  96. Brandenberger, H.,Rev. Ferment. Ind. Aliment. 11:237 (1956).

    CAS  Google Scholar 

  97. Kwon, R.A., K.H. Kim and J.S. Rhee,Kor. J. Appl. Microbiol. Bioeng. 15:122 (1987).

    CAS  Google Scholar 

  98. Kawashima, K., and K. Umeda,Agr. Biol. Chem. 40:1143 (1976).

    CAS  Google Scholar 

  99. Suzuki, S., and I. Karube,Japan Kokai 77:156,990 (1977).

    Google Scholar 

  100. Omar, I.C., H. Saeki, N. Nishio and S. Nagai,Agric. Biol. Chem. 52:99 (1988).

    CAS  Google Scholar 

  101. Kubo, M., I. Karube and S. Suzuki,Biochem. Biophys. Res. Commun. 69:731 (1976).

    Article  CAS  Google Scholar 

  102. van der Padt, A., M.J. Edema, J.J.W. Sewalt and K. van't Riet,J. Am. Oil Chem. Soc. 67:347 (1990).

    Google Scholar 

  103. Pronk, W., P.J.A.M. Kerkhof, C. van Helden and K. van't Riet,Biotechnol. Bioeng. 32:512 (1988).

    Article  CAS  Google Scholar 

  104. Pannell, L., M.S. Thesis, University of Wisconsin, Madison (1989).

  105. Kitajima, M., S. Miyano and A. Kondo,Kogyo Kaguku Zasshi 72:493 (1969).

    CAS  Google Scholar 

  106. Brockman, H.L., J.H. Law and F.J. Kézdy,J. Biol. Chem. 248:4965 (1973).

    CAS  Google Scholar 

  107. Hills, M.J., I. Kiewitt and K.D. Mukherjee,Biochem. Soc. Trans. 17:478 (1989).

    CAS  Google Scholar 

  108. Kadyrova, Z.K., S.A. Abdurakhimov and K.K. Khalniyazov,Khimi. Prir. Soedin. 4:439 (1983).

    Google Scholar 

  109. Wisdom, R.A., P. Dunnill and M.D. Lilly,Enzyme Microb. Technol. 7:567 (1985).

    Article  CAS  Google Scholar 

  110. Hoq, M.M., T. Yamane, S. Shimizu, T. Funada and S. Ishida,J. Am. Oil Chem. Soc. 62:1016 (1985).

    Article  CAS  Google Scholar 

  111. Hoq, M.M., H. Tagami, T. Yamane and S. Shimizu,Agric. Biol. Chem. 49:335 (1985).

    CAS  Google Scholar 

  112. Brady, C., L. Metcalfe, D. Slaboszewski and D. Frank,J. Am. Oil Chem. Soc. 65:917 (1988).

    CAS  Google Scholar 

  113. Kang, S.T., and J.S. Rhee,Biotechnol. Lett. 10:341 (1988).

    Article  CAS  Google Scholar 

  114. Kang, S.T., and J.S. Rhee,Biotechnol. Bioeng. 33:1469 (1989).

    Article  CAS  Google Scholar 

  115. Brady, C.D., L.D. Metcalfe, D.R. Slaboszewski and D. Frank, U.S. Patent No. 4,629,742 (1986).

  116. Brady, C.D., L.D. Metcalfe, D.R. Slaboszewski and D. Frank,Ibid. U.S. Patent No. 4,678,580 (1987).

  117. Wisdom, R.A., P. Dunnill and M.D. Lilly,Biotechnol. Bioeng. 29:1081 (1987).

    Article  CAS  Google Scholar 

  118. Goderis, H.L., G. Ampe, M.P. Feyten, B.L. Fouwé and W.M. Guffens,Ibid. 30:258 (1987).

    Article  CAS  Google Scholar 

  119. Taylor, F., C.C. Panzer, J.C. Craig and D.J. O'Brien,Ibid. 28:1318 (1986).

    Article  CAS  Google Scholar 

  120. Hoq, M.M., T. Yamane, S. Shimizu, T. Funada and S. Ishida,J. Am. Oil Chem. Soc. 61:776 (1984).

    CAS  Google Scholar 

  121. Horiuti, Y., and S. Imamura,J. Biochem. 83:1381 (1978).

    CAS  Google Scholar 

  122. Kang, S.T., and J.S. Rhee,Biotechnol. Lett. 11:37 (1989).

    Article  CAS  Google Scholar 

  123. Yamane, T., T. Funada and S. Ishida,J. Ferment. Technol. 60:517 (1982).

    CAS  Google Scholar 

  124. Park, J.-H., and Y.-C. Lee,Korean J. Food Sci. Technol. 17:75 (1985).

    CAS  Google Scholar 

  125. Kosugi, Y., H. Suzuki and A. Kamibayashi,Japan. Kokai Tokyo Koho 79:76,892 (1979).

    Google Scholar 

  126. Kosugi, Y., and H. Suzuki,J. Ferment. Technol. 52:577 (1974).

    CAS  Google Scholar 

  127. Bell, G., J.R. Todd, J.A. Blain, J.D.E. Patterson and C.E. Shaw,Biotechnol. Bioeng. 23:1703 (1981).

    Article  CAS  Google Scholar 

  128. Patterson, J.D.E., J.A. Blain, C.E.L. Shaw, R. Todd and G. Bell,Biotechnol. Lett. 1:211 (1979).

    Article  CAS  Google Scholar 

  129. Kosugi, Y., and H. Suzuki,J. Ferment. Technol. 51:895 (1973).

    CAS  Google Scholar 

  130. Posorske, L.H., G.K. LeFebvre, C.A. Miller, T.T. Hansen and B.L. Glenvig,J. Am. Oil Chem. Soc. 65:922 (1988).

    CAS  Google Scholar 

  131. Jensen, B.H., D.R. Galluzzo and R.G. Jensen,Ibid. 65:905 (1988).

    Google Scholar 

  132. Hansen, T.T., and P. Eigtved,Proceedings of the World Conference on Emerging Trends in the Fats and Oil Industry, edited by A.R. Baldwin, American Oil Chemists' Society, Champaign, IL, 1986, p. 365.

    Google Scholar 

  133. Miller, C., H. Austin, L. Posorske and J. Gonzalez,J. Am. Oil Chem. Soc. 65:927 (1988).

    CAS  Google Scholar 

  134. Schuch, R., and K.M. Mukherjee,J. Agric. Food Chem. 35,1005 (1987).

    Article  CAS  Google Scholar 

  135. Eigtved, P., T.T. Hansen and H. Sakaguchi,J. Am. Oil Chem. Soc. 63:463 (1986).

    Google Scholar 

  136. Eigtved, P., Danish Patent Application No. 40,125/83 (1983).

  137. Kroll, J., F.R. Hassanien, E. Glapinska and C. Franzke,Die Nahrung 24:215 (1983).

    Article  Google Scholar 

  138. Wisdom, R.A., P. Dunnill, M.D. Lilly and A. Marcae,Enzyme Microb. Technol. 6:443 (1984).

    Article  CAS  Google Scholar 

  139. Macrae, A.R., inBiotechnology for the Oils and Fats Industry, edited by C. Ratledge, P. Dawson, and J. Rattray, American Oil Chemists' Society, Champaign IL, 1984, p. 189.

    Google Scholar 

  140. Ison, A.P., P. Dunnill and M.D. Lilly,Enzyme Microb. Technol. 10:47 (1988).

    Article  CAS  Google Scholar 

  141. Dierov, Z.K., A.A. Dikchyuvene and A.B. Paulyukonis,Khim. Prirodn. Soedin. 5:624 (1978).

    Google Scholar 

  142. Asaji, K., M. Kitajima and M. Shizuo, German Patent No. 1,943,608 (1971).

  143. Asaji, K., M. Kitajima and M. Shizuo, Japanese Patent No. 42,594 (1971).

  144. Neklyudov, A.D., B.D. Shvedov and V.V. Tsibanov,Prikl. Biokhim. Microbiol. 17:510 (1981).

    CAS  Google Scholar 

  145. Malcata, F.X., C.G., Hill and C.H. Amundson,Continuous Production of Lipolyzed Butterfat using a Membrane Reactor, paper presented at the IFT Annual Meeting, Anaheim CA (1990).

  146. Datta, R., and D.F. Ollis, inImmobilized Biochemicals and Affinity Chromatography, edited by R.B. Dunlap, Plenum Press, New York, 1974, p. 293.

    Google Scholar 

  147. Schafer, H.W.,Dissertation Abstr. Int. 36:1127B (1975).

    Google Scholar 

  148. Kosugi, Y., H. Igusa and N. TomizukaYukagaku 36:67 (1987).

    Google Scholar 

  149. Takahashi, K., Y. Tamaura, Y. Kodera, T. Mihama, Y. Saito and Y. Inada,Biochem. Biophys. Res. Comm. 142:291 (1987).

    Article  CAS  Google Scholar 

  150. Malcata, F.X., H.S. Garcia, C.G. Hill and C.H. Amundson,Biotech. Bioeng. submitted.

  151. Brockman, H.L., J. Law and F.J. Kézdy,J. Biol. Chem. 248:4965 (1973).

    CAS  Google Scholar 

  152. Sugiura, M., and M. Isobe,Chem. Pharm. Bull. 24:72 (1976).

    CAS  Google Scholar 

  153. Law, B.A., inAdvances in the Microbiology and Biochemistry of Cheese and Fermented Milk, edited by F.L. Davies and B.A. Law, Elsevier Applied Science Publishers, Amsterdam, 1984, p. 187.

    Google Scholar 

  154. Soda, M.,J. Food Protection 49:395 (1986).

    Google Scholar 

  155. Magee, E.L., and N.F. Olson,J. Dairy Sci. 64:600 (1981).

    CAS  Google Scholar 

  156. Magee, E.L., and N.F. Olson,Ibid. 64:611 (1981).

    CAS  Google Scholar 

  157. Magee, E.L., N.F. Olson and R.C. Lindsay,Ibid. 64:616 (1981).

    CAS  Google Scholar 

  158. Olson, N.F.,Ibid. 64:1063 (1981).

    Google Scholar 

  159. Arnadottir, A., M.S. Thesis, University of Wisconsin, Madison (1986).

  160. Braun, S.D., N.F. Olson and R.C. Lindsay,J. Food Sci. 47:1803 (1982).

    Article  CAS  Google Scholar 

  161. Braun, S.D., N.F. Olson and R.C. Lindsay,J. Food Biochem. 7:23 (1983).

    CAS  Google Scholar 

  162. Braun, S.D., Ph.D. Thesis, University of Wisconsin, Madison (1984).

  163. Braun, S.D., and N.F. Olson,J. Dairy Sci. 69, 1202 (1986).

    CAS  Google Scholar 

  164. Braun, S.D., and N.F. Olson,Ibid. 69:1209 (1986).

    Article  CAS  Google Scholar 

  165. Braun, S.D., and N.F. Olson,J. Microencapsulation 3:115 (1986).

    CAS  Google Scholar 

  166. Blain, J.A., J.D.E. Patterson, C.E.L. Shaw and W.A. Akhtar,Lipids 11:553 (1976).

    Article  CAS  Google Scholar 

  167. Brockman, H.L., inLipases, edited by B. Borgström and H.L. Brockman, Elsevier Science Publishers, Amsterdam, 1984, p. 3.

    Google Scholar 

  168. Michaelis, L., and M.L. Menten,Biochem. Z. 49:333 (1913).

    CAS  Google Scholar 

  169. Richardson, T. and D.B. Hyslop inFood Chemistry, edited by O.R. Fennema, Marcel Dekker Inc., New York, 1985, p. 371.

    Google Scholar 

  170. Benzonana, G., and P. Desnuelle,Biochem. Biophys. Acta 105:121 (1965).

    CAS  Google Scholar 

  171. Rietsch, J., F. Pattus, P. Desnuelle and R. Verger,J. Biol. Chem. 252:4313 (1977).

    CAS  Google Scholar 

  172. James, L.K., and L.G. Augenstein,Adv. Enzymol. 28:1 (1966).

    CAS  Google Scholar 

  173. Miller, I.R. and J.M. Ruysschaert,J. Colloid Interface Sci. 35:340 (1971).

    Article  CAS  Google Scholar 

  174. Cohen, H., B.W. Shen, W.R. Snyder, J.H. Law and F.J. Kézdy,Ibid. 56:240 (1976).

    Article  CAS  Google Scholar 

  175. Brockerhoff, H.,J. Biol. Chem. 246:5828 (1971).

    CAS  Google Scholar 

  176. Momsen, W.E., and H.L. Brockman,Ibid. 251:378 (1976).

    CAS  Google Scholar 

  177. Vandermeers, A., M.C. Vandermeers, J. Rathé and J. Cristophe,Biochim. Biophys. Acta 370:257 (1974).

    CAS  Google Scholar 

  178. Lilly, M.D., and J.M. Woodley, inBiocatalysis in Organic Syntheses, edited by J. Tramper, H.C. van der Plass, and P. Linko, Elsevier Applied Science Publishers, Amsterdam, 1985, p. 179.

    Google Scholar 

  179. Chibata, I., and T. Tosa, inImmobilized Enzyme Principles, edited by L.B. Wingard, E. Katchalski-Katzir, and L. Goldstein, Academic Press, New York, 1976, p. 329.

    Google Scholar 

  180. Khmelnitsky, Y.L., A.V. Levashov, N.L. Klyachko and K. Martinek,Enzyme Microb. Technol. 10:710 (1988).

    Article  Google Scholar 

  181. Messing, R.A., inImmobilized Enzymes for Industrial Reactors, edited by R.A. Messing, Academic Press, New York, 1975, p. 2.

    Google Scholar 

  182. Butler, L.G.,Enzyme Microb. Technol. 1:253 (1979).

    Article  CAS  Google Scholar 

  183. Zaks, A. and A.M. Klibanov,Proc. Natl. Acad. Sci. USA 82:3192 (1985).

    Article  CAS  Google Scholar 

  184. Klibanov, A.M.,TIBS 14:141 (1989).

    CAS  Google Scholar 

  185. Zaks, A., and A.M. Klibanov,Science 224:1249 (1984).

    Article  CAS  Google Scholar 

  186. Coleman, M.H., and A.R. Macrae, British Patent No. 1,577,933 (1980).

  187. Dohan, L.A., J.L. Beret, S. Pain and P. Delande, inEnzyme Engineering, edited by H. Weetall and G. Royer, Plenum Press, New York, Vol. 5, 1978, p. 279.

    Google Scholar 

  188. Lee, Y.-K., and C.-L. Choo,Biotechnol. Bioeng. 33:183 (1989).

    Article  CAS  Google Scholar 

  189. Anonymous,Technical Bulletin of Lipase APF-12-PR2, AMANO International Enzyme Co., Troy, VA, 1985.

  190. Arbige, M.V., P.R. Freund, S.C. Silver and J.T. Zelko,Food Technol. 40:91 (1986).

    CAS  Google Scholar 

  191. Barach, J.T., L.L. Talbot and S. Bush,J. Dairy Sci. 68 (suppl. 1):69 (1985).

    Google Scholar 

  192. Iwai, M., and Y. Tsujisaka, inLipases, edited by B. Borgström and H.L. Brockman, Elsevier Science Publishers, Amsterdam, 1984, p. 443.

    Google Scholar 

  193. Iwai, M., Y. Shimada and Y. Tsujisaka,J. Biochem. 88:533 (1980).

    CAS  Google Scholar 

  194. Benzonana, G.,Lipids 9:166 (1974).

    Article  CAS  Google Scholar 

  195. Davranov, K.D., and M. Pakhimov,Biokhimiya 46:250 (1981).

    CAS  Google Scholar 

  196. Yoshimoto, T., K. Takahashi, H. Nishimura, A. Ajima, Y. Tamaura and Y. Inada,Biotechnol. Lett. 6:337 (1984).

    Article  CAS  Google Scholar 

  197. Takahashi, K., H. Nishimura, T. Yoshimoto, M. Okada, A. Ajima, A. Matsushima, Y. Tamaura, Y. Saito and Y. Inada,Ibid. 6:765 (1984).

    Article  CAS  Google Scholar 

  198. Ajima, A., T. Yoshimoto, K. Takahashi, Y. Tamaura, Y. Saito and Y. Inada,Ibid. 7:303 (1985).

    Article  CAS  Google Scholar 

  199. Baillargeon, M.W. and P.E. Sonnet,J. Am. Oil Chem. Soc. 65:1812 (1988).

    CAS  Google Scholar 

  200. Deleuze, H., G. Lagrand, H. Millet, J. Baratti, G. Buonoi and C. Triantaphylides,Biochem. Biophys. Acta 911:117 (1987).

    CAS  Google Scholar 

  201. Inada, Y., H. Nishimura, K. Takahashi, T. Yoshimoto, A. Ranjan and Y. Saito,Biochem. Biophys. Res. Comm. 122:845 (1984).

    Article  CAS  Google Scholar 

  202. Inada, Y., K. Takahashi, T. Yoshimoto, A. Ajima, A. Matsushima and Y. Saito,TIBTECH 4:190 (1986).

    CAS  Google Scholar 

  203. Inada, Y., T. Yoshimoto, A. Matsushima and Y. Saito,Ibid. 4:68 (1986).

    CAS  Google Scholar 

  204. Kodera, Y., K. Takahashi, H. Nishimura, A. Matsushima, Y. Saito and Y. Inada,Biotechnol. Lett. 8:881 (1986).

    Article  CAS  Google Scholar 

  205. Matsushima, A., Y. Kodera, K. Takahashi, Y. Saito and Y. Inada,Ibid. 8:73 (1986).

    Article  CAS  Google Scholar 

  206. Matsushima, A., M. Okada, K. Takahashi, T. Yoshimoto and Y. Inada,Biochem. Intl. 11:551 (1985).

    CAS  Google Scholar 

  207. Takahashi, K., Y. Koderta, T. Yoshimoto, A. Ajima, A. Matsushima and Y. Inada,Biochem. Biophys. Res. Comm. 131:532 (1985).

    Article  CAS  Google Scholar 

  208. Takahashi, K., T. Yoshimoto, A. Yutaka and Y. Inada,Enzyme 32:235 (1984).

    CAS  Google Scholar 

  209. Yoshimoto, T., M. Nakata, S. Yamagushi, T. Funada, Y. Saito and Y. Inada,Biotechnol. Lett. 8:771 (1986).

    Article  CAS  Google Scholar 

  210. Butter, L.G.,Enzyme Microb. Technol. 1:253 (1979).

    Article  Google Scholar 

  211. Yamane, T.,J. Am. Oil Chem. Soc. 64:12 (1987).

    Google Scholar 

  212. P.E. Sonnet,Ibid. 65:900 (1988).

    CAS  Google Scholar 

  213. Lombardo, D., and O. Guy,Biochim. Biophys. Acta 659:401 (1981).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemical Engineering, University of Wisconsin, 53706, Madison, WI

    F. Xavier Malcata, Hector R. Reyes & Charles G. Hill Jr.

  2. Department of Food Science, University of Wisconsin, 53706, Madison, WI

    Hugo S. Garcia, Charles G. Hill Jr. & Clyde H. Amundson

Authors
  1. F. Xavier Malcata
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  2. Hector R. Reyes
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  3. Hugo S. Garcia
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  4. Charles G. Hill Jr.
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  5. Clyde H. Amundson
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Xavier Malcata, F., Reyes, H.R., Garcia, H.S. et al. Immobilized lipase reactors for modification of fats and oils—A review. J Am Oil Chem Soc 67, 890–910 (1990). https://doi.org/10.1007/BF02541845

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  • DOI: https://doi.org/10.1007/BF02541845

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