Abstract
The steady state kinetics of some typical catalytic systems of biological importance have been formulated. The conditions for the existence of a maximum or limiting velocity are examined and discussed. In particular it is shown that the limiting velocity for a given component is simply the rate expression for a given number of steps of theoverall process; from the general condition for a limiting velocity these steps may be specified. The stringency of the conditions which must be imposed upon the steady state solution in order that it may be assumed that one or more steps are essentially at equilibrium is pointed out. The application of the general method to coupled or branched systems and to cyclic systems is briefly discussed.
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This work was done while the author was a Senior Research Fellow of the National Institute of Health.
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Hearon, J.Z. The steady state kinetics of some biological systems: I. Bulletin of Mathematical Biophysics 11, 29–50 (1949). https://doi.org/10.1007/BF02477912
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DOI: https://doi.org/10.1007/BF02477912