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The use of two radiotracers for transfer-rate determinations in closed two compartment systems

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Abstract

The sensitivity and “specificity” of measurements for the determination of transferates are enhanced by the use of an additional radiotracer, serving to trace the unlabelled substance. This method presents advantages mostly in systems outside their steady state but only exeptionally in steady state systems.

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Literature

  • Robertson, J. S. 1957. “Theory and Use of Tracers in Determining Transfer Rates in Biological Systems.”Physiol. Rev.,37, 133–154.

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  • Sheppard, C. W. 1962.Basic Principles of the Tracer Method. New York: John Wiley & Sons, Inc.

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Authors and Affiliations

  1. Department of Microbiology, Michael Reese Hosptial and Medical Center, Chicago, Ill

    Felix Leitner

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  1. Felix Leitner
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Additional information

This paper is an outgrowth of work supported by grant AI 02457 from the National Institute of Allergy and Infectious Diseases, U.S. Public Health Service.

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Leitner, F. The use of two radiotracers for transfer-rate determinations in closed two compartment systems. Bulletin of Mathematical Biophysics 27, 431–434 (1965). https://doi.org/10.1007/BF02476847

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  • DOI: https://doi.org/10.1007/BF02476847

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