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Mathematical studies of the interaction of respiratory gases with whole blood II. CO2 absorption

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Abstract

Some progress has been made on the problem of the interaction of respiratory gases with whole blood. A working mathematical model for the O2−CO2 interaction phenomena has been developed from mathematical studies of the data. The Edsall-Wyman (1958) model for CO2 absorption is improved upon in this paper by consolidating it with the O2 absorption model developed in paper I of this set (Bernard, S. R.,Bull. Math. Biophysics,22, 391–415, 1960). This improved model assumed the effect of O2 on CO2 absorption is mediated through the electrical charge possessed by the hemoglobin molecule,i.e., O2 molecules bound to hemoglobin displace protons from the hemoglobin thereby increasing the negative charge on the hemoglobin and at the same time increasing the acidity of the solution. The model is tested against the data.

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Literature

  • Bernard, S. R. 1960. “Mathematical Studies of the Interaction of Respiratory Gases with Whole Blood. I. O2 Absorption.”Bull. Math. Biophysics.22, 391–415.

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  • Christianson, J., C. G. Douglas and J. S. Haldane. 1914. “The Absorption and Dissociation of Carbon Dioxide by Human Blood.”Jour. of Physiology.,43, 244–271.

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  • Edsall, J. T. and J. Wyman. 1958.Biophysical Chemistry. New York; Academic Press.

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  • Wyman, J. and D. W. Allen. 1951. “The Problem of the Heme Interactions and the Basis of the Bohr-Effect.”Jour. of Polymer Science. 5, 499–518.

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  1. S. R. Bernard (USPHS Predoctoral Fellow of the National Cancer Institute)

    Present address: Health Physics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

Authors and Affiliations

  1. Committee on Mathematical Biology, University of Chicago, Chicago, USA

    S. R. Bernard (USPHS Predoctoral Fellow of the National Cancer Institute)

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  1. S. R. Bernard
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Bernard, S.R. Mathematical studies of the interaction of respiratory gases with whole blood II. CO2 absorption. Bulletin of Mathematical Biophysics 23, 1–14 (1961). https://doi.org/10.1007/BF02476569

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  • DOI: https://doi.org/10.1007/BF02476569

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