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Analytical treatment of pattern formation in the Gierer-Meinhardt model of morphogenesis

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Summary

We first perform a linear stability analysis of the Gierer-Meinhardt model to determine the critical parameters where the homogeneous distribution of activator and inhibitor concentrations becomes unstable. There are two kinds of instabilities, namely, one leading to spatial patterns and another one leading to temporal oscillations. Focussing our attention on spatial pattern formation we solve the corresponding nonlinear equations by means of our previously introduced method of generalized Ginzburg-Landau equations. We explicitly consider the two-dimensional case and find both rolls and hexagon-like structures. The impact of different boundary conditions on the resulting patterns is also discussed. The occurrence of the new patterns has all the features of nonequilibrium phase transitions.

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References

  1. Babloyantz, A., Hiernaux, J.: Models for cell differentiation. Bull. Math. Biology37, 637–657 (1975)

    MATH  Google Scholar 

  2. Busse, F. H.: Patterns of convection in spherical shells. J. Fluid Mech.72, 67–85 (1975)

    Article  MATH  Google Scholar 

  3. Busse, F. H.: The stability of finite amplitude cellular convection and its relation to an extremum principle. J. Fluid Mech.30, 625–649 (1967)

    Article  MATH  Google Scholar 

  4. Busse, F. H.: Thermal Instabilities in rapidly rotating systems. J. Fluid Mech.44, 441 (1970)

    Article  MATH  Google Scholar 

  5. Di Prima, R. C., Eckhaus, W., Segel, L. A.: Nonlinear wave-number interaction in nearcritical two-dimensional flows. J. Fluid Mech.,49, 705–744 (1971)

    Article  Google Scholar 

  6. Gierer, A., Meinhardt, H.: Biological Pattern Formation Involving Lateral Inhibition. Lectures on Mathematics in Life Science.7, 163–183 (1974)

    MathSciNet  Google Scholar 

  7. Gierer, A., Meinhardt, H.: Theory of Biological Pattern Formation. Kybernetik12, 30–39 (1972)

    Article  Google Scholar 

  8. Granero, M. I., Porati, A., Zanacca, D.: A Bifurcation Analysis of Pattern Formation in a Diffusion Governed Morphogenetic Field. J. Math. Biology4, 21–27 (1977)

    Article  MATH  Google Scholar 

  9. Haken, H.: Generalized Ginsburg-Landau Equations for Phase Transition-like Phenomena in Lasers, Nonlinear Optics, Hydrodynamics and Chemical Reactions. Z. Phys.B21, 105 (1975)

    Google Scholar 

  10. Haken, H.: Higher Order Corrections to Generalized Ginsburg-Landau-Equations of Non-Equilibrium Systems. Z. PhysikB22, 69–72 (1975)

    Google Scholar 

  11. Haken, H.: Synergetics. An Introduction. Nonequilibrium Phase Transitions and Selforganization in Physics, Chemistry and Biology. Berlin, Heidelberg, New York: Springer, 1977

    Google Scholar 

  12. Levin, S. A.: Uniqueness Theorems for the Compressible Flow Equation. Appl. Anal.5, 207–215 (1976)

    MATH  Google Scholar 

  13. Newell, A. C., Whitehead, L. A.: Finite bandwidth, finite amplitude convection. J. Fluid Mech.38, 279–303 (1969)

    Article  MATH  Google Scholar 

  14. Mahar, T. J., Matkowsky, B. J.: A Model Biochemical Reaction Exhibiting Secondary Bifurcation. SIAM J. Appl. Math.32, 394 (1977)

    Article  MATH  MathSciNet  Google Scholar 

  15. Marsden, J. E.: The Hopf-Bifurcation and its Applications. Berlin, Heidelberg, New York: Springer, 1976

    MATH  Google Scholar 

  16. Matkowsky, B. J.: On boundary layer problems exhibiting resonance. SIAM Review17, 82 (1975)

    Article  MathSciNet  Google Scholar 

  17. Meinhardt, H., Gierer, A.: Applications of a Theory of Biological Pattern Formation Based on Lateral Inhibition. J. Cell Science15, 321–376 (1974)

    Google Scholar 

  18. Meinhardt, H.: The Spatial Control of Cell Differentiation by Autocatalysis and Lateral Inhibition. In: Synergetics, a Workshop. (H. Haken, ed.) Berlin, Heidelberg, New York: Springer, 1977

    Google Scholar 

  19. Sattinger, D. H.: Cooperative Effects in Fluid Problems. In: Synergetics, a Workshop. Berlin, Heidelberg, New York: Springer, 1977

    Google Scholar 

  20. Segel, L. A., Levin, S. A.: Application of nonlinear stability theory to the study of the effects of diffusion on predator-prey interactions. AIP Conference Proceedings27, 123–152 (1976)

    Article  MathSciNet  Google Scholar 

  21. Turing, A. M.: The Chemical Basis of Morphogenesis. Phil. Transactions of the Royal SocietyB237, 37–72 (1952)

    Google Scholar 

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Haken, H., Olbrich, H. Analytical treatment of pattern formation in the Gierer-Meinhardt model of morphogenesis. J. Math. Biology 6, 317–331 (1978). https://doi.org/10.1007/BF02462997

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  • DOI: https://doi.org/10.1007/BF02462997

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