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A two-backbone polymer model for interphase chromosome geometry

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Abstract

A polymer model for the overall geometric structure of a human chromosome during the G0/G1 portion of cell-cycle interphase is constructed, based on fluorescencein situ hybridization data on distances between defined genomic sequences. The model consists of flexible giant loops, averaging about 6 million base pairs, with two random-walk backbones; it involves essentially three parameters. Numerical results based on properly selected values of parameters fit the data well.

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Authors and Affiliations

  1. Department of Mathematics, College of St. Scholastica, 55811, Duluth, MN, U.S.A.

    Bing Liu

  2. Department of Mathematics, University of California, 94720, Berkeley, CA, U.S.A.

    Rainer K. Sachs

Authors
  1. Bing Liu
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  2. Rainer K. Sachs
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Liu, B., Sachs, R.K. A two-backbone polymer model for interphase chromosome geometry. Bltn Mathcal Biology 59, 325–337 (1997). https://doi.org/10.1007/BF02462006

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  • DOI: https://doi.org/10.1007/BF02462006

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