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A multiple sequence comparison method

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Abstract

This article presents a new method for the comparison of multiple macromolecular sequences. It is based on a hierarchical sequence synthesis procedure that does not require anya priori knowledge of the molecular structure of the sequences or the phylogenetic relations among the sequences. It differs from the existing methods as it has the capability of: (i) generating a statistical-structural model of the sequences through a synthesis process that detects homologous groups of the sequences, and (ii) aligning the sequences while the taxonomic tree of the sequences is being constructed in one single phase. It produces superior results when compared with some existing methods.

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Authors and Affiliations

  1. Department of Systems Design Engineering, University of Waterloo, N2L 3G1, Waterloo, Canada

    A. K. C. Wong & S. C. Chan

  2. Department of Computing and Information Science, University of Guelph, N1G 2W1, Guelph, Canada

    D. K. Y. Chiu

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  1. A. K. C. Wong
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  2. S. C. Chan
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  3. D. K. Y. Chiu
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Wong, A.K.C., Chan, S.C. & Chiu, D.K.Y. A multiple sequence comparison method. Bltn Mathcal Biology 55, 465–486 (1993). https://doi.org/10.1007/BF02460892

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  • DOI: https://doi.org/10.1007/BF02460892

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