Abstract
A non-linear three-compartment model is proposed to describe a new strategy for the administration of 2′,3′-dideoxycytidine (ddCyd) in the treatment of HIV infections. The drug is injected after having been encapsulated in a non-diffusible form (ddCMP) into erythrocytes. Nummerical solutions show that by this treatment the highest ddCyd blood concentration is strongly reduced and in turn its toxicity, while long-lasting therapeutic effect is assured. The model is compared with experimental data in vitro.
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Solimano, F., Bischi, G.I., Bianchi, M. et al. A nonlinear three-compartiment model for the administration of 2′,3′-dideoxycytidine by using red blood cells as bioreactors. Bltn Mathcal Biology 52, 785–796 (1990). https://doi.org/10.1007/BF02460809
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DOI: https://doi.org/10.1007/BF02460809