Skip to main content
SpringerLink
Log in

Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal

  • Published:
Bulletin of Mathematical Biology Aims and scope Submit manuscript

Abstract

To explore the biological similarities and differences between the HIV-1 and HIV-2 viruses, we model the probability of male-to-female transmission of either HIV virus as a function of the number of sexual partners, the prevalence of the viruses and the infectivity per contact. Using maximum likelihood estimation theory and data from a prospective study of registered female prostitutes in Dakar, Senegal, we estimate and compare the infectivities of HIV-1 and HIV-2. Graphical goodness-of-fit methods are used to show that our model fits the data well. We find that in male-to-female transmission HIV-1 is significantly more infectious than HIV-2. This findings is consistent with other data from laboratory and epidemiologic studies comparing the biology of HIV-1 and HIV-2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature

  • Albert, J., A. Haucler, B. Bottiger, P.-A. Broliden, P. Albino, S. A. Ouattara, C. Björkegren, A. Valentin, G. Biberfeld and E. M. Fenyö. 1990. Replicative capacity of HIV-2, like HIV-1, correlates with severity of immunodeficiency.AIDS 4(4), 291–295.

    Article  Google Scholar 

  • Ancelle, R., O. Bletry, A. C. Baglin, F. Brun-Vézinet, M. A. Rey and P. Godeau. 1987. Long incubation period for HIV-2 infection.The Lancet I, 688–689.

    Article  Google Scholar 

  • Barré-Sinoussi, F., J. C. Chermann, F. Rey, M. T. Nugeyre, S. Chamaret, J. Gruest, C. Dauguet, C. Axler-Blin, F. Vézinet-Brun, C. Rouzioux, W. Rozenbaum and L. Montagnier. 1983. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).Science 220, 868–871.

    Google Scholar 

  • Barin, F., S. M'Boup, F. Denis, P. Kanki, J. S. Allan, T. H. Lee and M. Essex. 1985. Serological evidence for virus related to simian T-lymphotropic retrovirus III in residents of west Africa.The Lancet ii, 1387–1389.

    Article  Google Scholar 

  • Biberfeld, B., F. Brown, J. Esparza, M. Essex, R. C. Gallo, L. Montagnier, R. Najera, R. Risser and G. Schild. 1987. Meeting report, WHO working group on characterization of HIV-related retroviruses: criteria for characterization and proposal for a nomenclature system.AIDS I, 189–190.

    Google Scholar 

  • Centers for Disease Control. 1981. Pneumocystis pneumonia—Los Angeles.Morbid. Mortal. Weekly Rep. 30, 250–252.

    Google Scholar 

  • Clavel, F., D. Guétard, F. Brun-Vézinet, S. Chamaret, M. A. Rey, M. O. Santos-Ferreira, A. G. Laurent, C. Dauguet, C. Katlama, C. Rouzioux, D. Klatzmann, J. L. Champalimaud and L. Montagnier. 1986. Isolation of a new human retrovirus from West African patients with AIDS.Science 233, 343–346.

    Google Scholar 

  • Clavel, F., K. Mansinho, S. Chamaret, D. Guétard, V. Favier, J. Nina, M. O. Santos-Ferreira, J. L. Champalimaud and L. Montagnier. 1987. Human immunodeficiency virus type 2 infection associated with AIDS in West Africa.N. Engl. J. Med. 316, 1180–1185.

    Article  Google Scholar 

  • De Gruttola, V. and K. H. Mayer. 1988. Assessing and modeling heterosexual spread of the Human Immunodeficiency Virus in the United States.Rev. infect. Dis. 10, 138–150.

    Google Scholar 

  • Evans, L. A., J. Moreau, K. Odehouri, D. Seto, G. Thomson-Honnebive, H. Legg, A. Barboza, C. Cheng-Meyer and J. A. Levy. 1988. Characterization of a noncytopathic HIV-2 strain with unusual effects on CD-4 expression.Science 240, 1522–1525.

    Google Scholar 

  • Gallo, R. C., S. Z. Salahuddin, M. Popovic, G. M. Shearer, M. Kaplan, B. F. Haynes, T. J. Palker, R. Redfield, J. Oleske, B. Safai, G. White, P. Foster and P. D. Markham. 1984. Frequent detection and isolation of cytopathic retroviruses (HTLV III) from patients with AIDS and at risk for AIDS.Science 224, 500–503.

    Google Scholar 

  • Grant, R. M., J. A. Wiley and W. Winkelstein. 1987. Infectivity of the Human Immunodeficiency Virus: estimates from a prospective study of homosexual men.J. infect. Dis. 156, 189–193.

    Google Scholar 

  • Hammond, G. 1989. Human immunodeficiency virus type 2.Can. Med. Ass. J. 140, 121–122.

    Google Scholar 

  • Horsburgh, C. R. and S. D. Holmberg. 1988. The global distribution of human immunodeficiency virus type 2 (HIV-2) infection.Transfusion 28, 192–195.

    Article  Google Scholar 

  • Jewell, N. P. and S. C. Shiboski. 1990. Statistical analysis of HIV infectivity based on partner studies.Biometrics 46, 1133–1150.

    Article  Google Scholar 

  • Kanki, P. J. 1987. West African human retroviruses related to STLV-III.AIDS I, 141–145.

    Google Scholar 

  • Kanki, P., R. Marlink, S. M'Boup and M. Essex. 1990a. Epidemiology of HIV-2 in prostitutes in Senegal (abstract).AIDS Res. Hum. Retroviruses 6, 76.

    Google Scholar 

  • Kanki, P. J., R. G. Marlink, T. Siby, M. Essex and S. M'Boup. 1990b. Biology of HIV-2 infection in West Africa. InGene Regulation and AIDS. T. S. Papas (Ed.), pp. 255–272. Woodlands, TX: Portfolio Publishing.

    Google Scholar 

  • Kanki, P., S. M'Boup, R. Marlink, K. Travers, A. Gueye, C. Boye, J.-L. Sankalé, C. Donnelly, W. Leisenring, T. Siby, I. Thior, M. Dia, E-H. Gueye, C. Hsieh, I. N'Doye and M. Essex. 1992. Prevalence and risk determinants of Human Immunodeficiency Virus type 2 (HIV-2) and Human Immunodeficiency Virus type 1 (HIV-1) in West African female prostitutes.Am. J. Epidemiol. 136, 895–907.

    Article  Google Scholar 

  • Kim, M. Y. and S. W. Lagakos. 1990. Estimating the infectivity of HIV from partner studies.Ann. Epidemiol. 1, 117–128.

    Article  Google Scholar 

  • Kong, L. I., S.-W. Lee, J. C. Kappes, J. S. Parkins, D. Decker, J. A. Hoxie, B. H. Hahn and G. M. Shaw. 1988. West African HIV-2 related human retrovirus with attenuated cytopathicity.Science 240, 1525–1529.

    Google Scholar 

  • Lehmann, E. L. 1983.Theory of Point Estimation, Ch. 6. New York: John Wiley and Sons.

    MATH  Google Scholar 

  • Marlink, R., S. M'Boup, P. Kanki, T. Siby, I. Thior, K. Travers, J. Hellinger, A. Gueye, J.-L. Sankalé, C. Boye, I. N'Doye and M. Essex. Clinical outcome in a prospective cohort of HIV-2 and HIV-1 infected female prostitutes in Senegal. Submitted.

  • Marlink, R. G., D. Ricard, S. M'Boup, P. J. Kanki, J.-L. Romet-Lemonne, I. N'Doye, K. Diop, M. A. Simpson, F. Greco, M.-J. Chou, V. DeGruttola, C.-C. Hsieh, C. Boye, F. Barin, F. Denis, M. F. McLane and M. Essex. 1988. Clinical, hematologic, and immunologic cross-sectional evaluation of individuals exposed to Human Immunodeficiency Virus type 2 (HIV-2).AIDS Res. Hum. Retroviruses 4, 137–148.

    Article  Google Scholar 

  • Press, W. H., B. P. Flannery, S. A. Teukolsky and W. T. Vetterling. 1988.Numerical Recipes in C, Ch. 9. Cambridge, U.K.: University of Cambridge Press.

    MATH  Google Scholar 

  • Romieu, I., R. Marlink, P. J. Kanki, S. M'Boup and M. Essex. 1990. HIV-2 link to AIDS in West Africa.J. AIDS 3, 220–230.

    Google Scholar 

  • Sandberg, S. and T. A. Awerbuch. 1989. Mathematical formulation and studies of the risk parameters involved in HIV transmission.Bull. math. Biol. 51, 467–474.

    Article  Google Scholar 

  • SAS Institute Inc. 1987. SAS Proprietary Software Release 6.04. Copyright © 1985, 1986, 1987. Cary, NC.

Download references

Author information

Authors and Affiliations

  1. Department of Biostatistics, Harvard School of Public Health, 02115, Boston, MA, U.S.A.

    Christl Donnelly, Wendy Leisenring & Tamara Awerbuch

  2. Department of Cancer Biology, Harvard School of Public Health, 02115, Boston, MA, U.S.A.

    Phyllis Kanki

  3. Framingham State College, Bunting Fellow at Harvard University and Mathematics Department, 01701, Framingham, MA, U.S.A.

    Sonja Sandberg

Authors
  1. Christl Donnelly
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wendy Leisenring
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Phyllis Kanki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tamara Awerbuch
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sonja Sandberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Donnelly, C., Leisenring, W., Kanki, P. et al. Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal. Bltn Mathcal Biology 55, 731–743 (1993). https://doi.org/10.1007/BF02460671

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02460671

Keywords

Search

Navigation