Abstract
This work continues with an examination of capillary exchange models as operators, namely the operatorsO k andK αk relating extravascular and intravascular concentration to input for the Krogh cylinder model of a single capillary, a model basic to many organ models. Fundamental algebraic and analytic properties are presented: the operators belong to a commutative Banach algebra; an addition theorem holdsK αk +K βk =K α+β,k ; the operatorK αk has an inverse;K -1 αk , (as an operator on LebesgueL p space or on the locally integrable functions); partial derivatives are given forK αk [f](t) andO k [f](t) (sensitivity functions); and inequalities are established for the derivatives. Dominance relations between model curves are inferred. Error bound formulas are presented forK andO as bounds on ‖K αk f-K βl f‖ p and ‖O k f-O l f‖ p for allL p . Consequent limitations on relative errors are shown. The implications for operators on a finite time interval are deduced.
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Literature
Bateman, J. M. and T. R. Harris. 1984. “Capillary Operators.”Bull. math. Biol. 46, 247–268.
Bonsall, F. F. and J. Duncan. 1973.Complete Normed Algebras. Berlin: Springer-Verlag.
Hall, M. 1959.The Theory of Groups. New York: Macmillan.
Jacquez, J. A. 1972.Compartmental Analysis in Biology and Medicine: Kinetics of Distribution of Tracer-labeled Materials. Amsterdam: Elsevier/Excerpta Medica/North-Holland.
Lang, S. 1969.Real Analysis. Reading, Massachusetts: Addison Wesley.
— 1984.Algebra. Menlo Park, California: Addison Wesley.
McShane, E. J. and T. A. Botts. 1959.Real Analysis. Princeton, New Jersey: Van Nostrand.
Olmsted, J. 1961.Advanced Calculus. New York: Appleton-Century-Crofts.
Rose, C. P. and C. A. Goresky. 1976. “Vasomotor Control of Capillary Transit Time Heterogeneity in the Canine Coronary Circulation.”Circulation Res.39, 541–554.
Rowlett, R. D. and T. R. Harris. 1976. “A Comparative Study of Organ Models and Numerical Techniques for the Evaluation of Capillary Permeability from Multipleindicator Data.”math. Biosci. 29, 273–298.
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This work supported in part by PHS Grant Nos HL-19153 (SCOR and Pulmonary Vascular Disease) and HL-19370 at Vanderbilt University Medical School.
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Bateman, J.M. Capillary operators—II. Bltn Mathcal Biology 47, 651–668 (1985). https://doi.org/10.1007/BF02460131
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DOI: https://doi.org/10.1007/BF02460131