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Transient transport across the blood-retina barrier

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Abstract

A mathematical model of the transport of fluorescein across the blood-retina barrier in the transient state and the subsequent diffusion of fluorescein in the vitreous body is presented. The function of the barrier is lumped in a single parameter—the permeability. The sensitivity of this parameter due to changes in the other parameters of the model is given. This establishes the foundation for the quantitative assessment of the barrier function through vitreous fluorophotometry.

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Authors and Affiliations

  1. MATH-TECH Institute, Sommervej 7, DK-2920, Charlottenlund, Denmark

    Jesper Larsen

  2. University Eye Clinic, Rigshospitalet, E2061, DK-2100, Copenhagen, Denmark

    Henrik Lund-Andersen & Bent Krogsaa

Authors
  1. Jesper Larsen
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  2. Henrik Lund-Andersen
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  3. Bent Krogsaa
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Larsen, J., Lund-Andersen, H. & Krogsaa, B. Transient transport across the blood-retina barrier. Bltn Mathcal Biology 45, 749–758 (1983). https://doi.org/10.1007/BF02460047

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  • DOI: https://doi.org/10.1007/BF02460047

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