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A new measure of xenobiotic toxicity to the first-line human defence system from the time-resolved phagocyte luminescence

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Abstract

A new measure of toxicity based on stochastic modelling of single photon-counting processes, representing time-resolved phagocyte luminescence of xenobiotic-perturbed human neutrophils, has been constructed. The stochastic measure of toxicity has been verified by the QSAR method, and then compared and contrasted with the traditional toxicity measure used in bio- and chemiluminescent research. Phenol and benzene homologues were chosen as perturbers due to their importance from the viewpoint of ecotoxicology and occupational medicine.

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Authors and Affiliations

  1. Department of Toxicology, Wroclaw University of Medicine, PL-50417, Wroclaw, Poland

    Bonawentura Kochel & Waldemar Sajewicz

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  1. Bonawentura Kochel
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  2. Waldemar Sajewicz
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Correspondence to Bonawentura Kochel.

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Kochel, B., Sajewicz, W. A new measure of xenobiotic toxicity to the first-line human defence system from the time-resolved phagocyte luminescence. Bltn Mathcal Biology 59, 897–910 (1997). https://doi.org/10.1007/BF02459998

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  • DOI: https://doi.org/10.1007/BF02459998

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