Abstract
A class of non-linear similarity functionss 1 has been proposed for comparing subalignments of biological sequences. The distribution of maximals 1-similarities is well approximated by the extreme value distribution. The significance levels ofs 1 are studied for a variety of nucleotide frequency distributions as well as for several matrices of amino acid substitution costs. Also, the significance levels ofs 1 are explored for comparing three biological sequences. Several previously described subalignments of bovine proenkephalin and porcine prodynorphin are shown to be highly significant.
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Altschul, S.F., Erickson, B.W. Significance levels for biological sequence comparison using non-linear similarity functions. Bltn Mathcal Biology 50, 77–92 (1988). https://doi.org/10.1007/BF02459979
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DOI: https://doi.org/10.1007/BF02459979