Abstract
Proposed model geometries are described for three types of axisymmetric and four types of flattened sickled erythrocytes. The axisymmetric types are designated as concave-convex, convex-convex and parabolic, while the flattened types carry designations of concave-convex, convex-convex, parabolic and S-shaped. Formulae are provided for the volume and surface area of each type and a figure showing the profile of each is included. Measurements of actual sickled cellsin vitro could be used to find values for the volume and surface area of each type of cell by using parameter values for the appropriate model geometry. These would give close approximations that could be useful in clinical therapies and laboratory investigations for sickle cell anemia. Surface area to volume ratios can also be found to a close approximation for each cell type.
Similar content being viewed by others
Literature
Barnhart, M. L. 1971. “Microscopy of the Sickle-Desickle Transition.” InMolecular Aspects of Sickle Cell Hemoglobin, R. M. Nalbandian (Ed.), pp. 45–116. Springfield: Charles Thomas.
Bessis, M. 1973. “Red Cell Shape: An Illustrated Classification and its Rationale.” InRed Cell Shape, M. Bessis, R. I. Weed and P. F. Leblond (Eds), pp. 1–23. New York: Springer.
Herrick, J. B. 1910. “Peculiar Elongated and Sickle-shaped Red Blood Corpuscles in a Case of Severe Anemia.”Archs intern. Med. 6, 517–521.
Jensen, W. N. and P. P. Klug. 1973. “Cell Membrane in Sickle Cell Disease.” InSickle Cell Disease, H. Abramson, J. F. Bertles and D. L. Wethers (Eds), pp. 130–139. St. Louis: C. V. Mosby.
Nalbandian, R. M., B. M. Nichols, E. J. Stehouwer and F. R. Camp, Jr. 1972. “Urea, Urease Cyanate, and the Sickling of Hemoglobin S.”Clin. Chem. 18, 961–964.
Takashima, S., S. Chang and T. Asakura. 1985. “Shape Change of Sickled Erythrocytes Induced by Pulsed rf Electrical Fields.”Proc. natn. Acad. Sci. U.S.A. 82, 6860–6864.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vayo, H.W. Model geometries for sickled erythrocytes. Bltn Mathcal Biology 49, 403–411 (1987). https://doi.org/10.1007/BF02458859
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02458859