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The expected fraction of clonable genomic DNA

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Abstract

Random clone mapping of genomic DNA is a subject of great interest in molecular biology.E. coli has just been mapped and work is progressing on some human chromosomes. In this paper we give estimates of the fraction of genomic DNA which is not clonable by partial digest with a restriction enzyme.

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Authors and Affiliations

  1. Department of Mathematics, University of Southern California, 90089-1113, Los Angeles, CA, U.S.A.

    Betty Tang & Michael S. Waterman

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  1. Betty Tang
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  2. Michael S. Waterman
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Research supported by grants from the National Institutes of Health and the System Development Foundation.

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Tang, B., Waterman, M.S. The expected fraction of clonable genomic DNA. Bltn Mathcal Biology 52, 455–475 (1990). https://doi.org/10.1007/BF02458581

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  • DOI: https://doi.org/10.1007/BF02458581

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