Abstract
Mononuclear phagocytes are frequently found adjacent to active bone-resorbing surfaces in both physiological and pathological bone resorption, being implicated as important cellular elements in the process of bone resorption. In this study an attempt was made to prepare several groups of peritoneal exudate cells (PEC) induced by bone powder (B-PEC), glycogen (G-PEC) or paraffin oil (P-PEC), to investigate the chemotactic response to bone powder suspension or bone matrix and the superoxide production.
B-PEC migrated to bone powder or bone matrix more readily than the other exudate cells (G-PEC and P-PEC) did. An checkerboard analysis showed that there was a chemokinetic activity in bone matrix, besides chemotactic activity. Superoxide production by bone matrix, however, remained unchanged in each cell group. These results suggest that there is a macrophage subset possessing a specific migratory characteristic toward the bone tissue.
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Yagami, K. Chemotaxis of rat peritoneal macrophages induced by rat bone powder. J Bone Miner Metab 6, 32–37 (1988). https://doi.org/10.1007/BF02378737
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DOI: https://doi.org/10.1007/BF02378737