Abstract
Serial changes in the levels of cholecystokinin (CCK)-A receptor mRNA in the pancreas after pancreatic duct occlusion were examined in rats. CCK-A receptor mRNA level was determined by Northern blot analysis with a rat CCK-A-receptor cDNA probe. The level of CCK-A receptor mRNA first decreased, reaching the lowest level 7 days after occlusion, and then began to increase. On day 14, it had completely recovered to the control level and it remained at that level until 28 days after occlusion.
References
Miyasaka K, Funakoshi A, Jimi A, et al. Changes in plasma and duodenal cholecystokinin concentrations after pancreatic duct occlusion in rats. Dig Dis Sci 1992;37:369–377.
Tomita H, Miyasaka K, Jimi A, et al. Lack of effect of cholecystokinin receptor antagonist (CR1505) on recovery of experimental pancreatitis after pancreatic duct occlusion in rats. Pancreas 1994;9:638–645.
Funakoshi A, Miyasaka K, Jimi A, et al. Changes in gene expressions of pancreatitis-associated protein and pancreatic secretory strypsin inhibitors in experimental pancreatitis preduced by pancreatic duct occlusion in rats: Comparison with gene duced by pancreatic duct occlusion in rats: Comparison with gene expressions of cholecystokinin and secretin. Pancreas (in press).
Niederau C, Liddle RA, Williams TA. Pancreatic growth: Interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice. Gut 1987;28: 63–69.
Mainz DL, Black O, Webster D. Hormonal control of pancreatic growth. J Clin Invest 1973;52:2300–2304.
Wank SA, Harkins R, Jensen RT, et al. Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas. Proc Natl Acad Sci USA 1992;89: 3125–3129.
Funakoshi A, Miyasaka K, Jimi A, et al. Little or no expression of the cholecystokinin-A receptor gene in the pancreas of diabetic rats (Otsuka Long-Evans Tokushima Fatty-OLETF rats). Biochem Biophys Res Comm 1994;199:482–488.
Funakoshi A, Tanaka A, Kawanami T, et al. Expression of the cholecystokinin precursor gene in rat tissues. J Gastroenterology 1994;29:125–128.
Yazu T, Kimura T, Sumii T, et al. Alteration of cholecystokinin receptor binding after caerulein-induced pancreatitis in rats. Digestion 1991;50:142–148.
Gomez G, Beauchamp RD, Rajaraman S, et al. Type A cholecystokinin receptors and pancreatic enzyme mRNA levels are down-regulated in acute pancreatitis (abstract). Gastroenterology 1993;104:A305.
Tomita H, Myasaka K, Jimi A, et al. The effect of excessive doses of cerulein on various stages of pancreatitis produced by pancreatic duct ligation in rats (in Japanese with English abstract). Suizou (J Japan Pancreas Soc) 1994;9:278–293.
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Miyasaka, K., Funakoshi, A. Changes in gene expression of cholecystokinin-A receptor after induction of pancreatitis by pancreatic duct occlusion in rats. J Gastroenterol 30, 683–685 (1995). https://doi.org/10.1007/BF02367799
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DOI: https://doi.org/10.1007/BF02367799