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Acceleration of turnover of14C-catecholamines in rat brain by chlorpromazine

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  • Chimica. Biochimica. Biophysica
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Zusammenfassung

Vorbehandlung mit 10 mg/kg Chlorpromazin (CPZ) i.p. bewirkt bei Ratten, denen14C-Tyrosin injiziert wurde, eine Zunahme der spezifischen Radioaktivität von14C-Dopamin im Gehirn. CPZ beschleunigt bei Tieren, deren zerebrale Katecholamine durchl-214C-Dopa markiert wurden, den Abfall der spezifischen Radioaktivität von Dopamin und Noradrenalin. Daraus wird geschlossen, dass CPZ den Umsatz zerebraler Katecholamine erhöht.

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Authors and Affiliations

  1. Forschungsabteilung der F. Hoffmann-La Roche & Co. AG, Basel, Switzerland

    K. F. Gey & A. Pletscher

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  1. K. F. Gey
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  2. A. Pletscher
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Gey, K.F., Pletscher, A. Acceleration of turnover of14C-catecholamines in rat brain by chlorpromazine. Experientia 24, 335–336 (1968). https://doi.org/10.1007/BF02140804

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