Résumé
Chez le poussins de 1–14 jours l'agent inhibitoire de déhydrogénation d'alcohol et pyrazol prologeait considérablement la période de sommeil produit par 5-hydroxy-tryptophol, les données d'ensemble suggérant que ce dernier composé est le métabolite neutre, somnifère, de 5-hydroxytryptamine.
References
B. B. Brodie andP. A. Shore, N.Y. Acad. Sci.66, 631 (1957).
B. B. Brodie, S. Spector andP. A. Shore, Pharmac. Rev.11, 548 (1959).
W. G. Dewhurst, Nature218, 1130 (1968).
W. G. Dewhurst,Studies in Psychiatry (Oxford University Press 1968), p. 289.
S. Kveder, S. Iskric andD. Keglevic, Biochem. J.85, 447 (1962).
A. Feldstein andK. K. Wong, Analyt. Biochem11, 467 (1965).
D. Eccleston, A.T.B. Moir, H. W. Reading andI. M. Ritchie, Br. J. Pharm. Chemother.28, 367 (1966).
C. E. Spooner andW. D. Winters, Experientia21, 256 (1965);C. E. Spooner andW. D. Winters, Int. J. Neuropharm.6, 109 (1967).
A. H. Neims, D. S. Coffey andI. Hellerman, J. biol. Chem.241, 5941 (1962).
V. Erspamer, Sub-Editor,5-Hydroxytryptamine and Related Amines (Springer-Verlag, Inc., New York 1966) 618.
D. Lester, W. Z. Keokosky andF. Felzenberg, Q. Jl, Stud. Alcohol29, 449 (1968).
J. Mouret, P. Bobillier andM. Jouvet, Europ. J. Pharm.5, 17 (1968).
M. Jouvet, Science163, 32 (1969).
D. J. Mahler andF. Humollier, Int. J. Neuropsyol.3, 229 (1967).
H. C. Sabelli, W. J. Giardina, S. G. A. Alivisatos, P. K. Seth andF. Ungar, Nature, Lond.223, 73 (1969).
P. Delvigs, W. M. McIsaac andR. G. Taborsky, J. biol. Chem.240, 348 (1965).
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This work was supported by funds from Enzomedic Laboratoires, Incorporated.
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Taborsky, R.G. 5-Hydroxytryptophol: Evidence for its having physiological properties. Experientia 27, 929–930 (1971). https://doi.org/10.1007/BF02135750
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DOI: https://doi.org/10.1007/BF02135750