The mammary gland: A unique organ for the study of development and tumorigenesis
- Daniel Medina
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The microanatomy and development of the mammary gland are unique and a reflection of its function to synthesize and deliver milk to the newborn offspring. The uniqueness of the mammary gland resides in several factors. First, the mammary parenchyma undergoes the vast majority of its growth postpubertally, thus enabling experiments on development to be performed in the juvenile or adult and presenting opportunities for experimental manipulation of the gland not available with other organs. On the basis of this characteristic, the fat pad transplantation method was developed, which resulted in the elaboration of important concepts in senescence, immortalization, and preneoplasia. Second, the accessibility of the gland and the ductal organization allows delivery and localization of specific molecules to mammary parenchyma cells, the cells which are the site of origin of neoplastic development. Third, the organ is the target of viral, chemical, and physical carcinogens, allowing development of unique and complex models for neoplastic development. Finally, the complexity of hormone and growth factor regulation of mammary gland function allows a sophisticated approach to the study of hormone action. The purpose of this review is to illustrate some unique properties of the gland which provide the basis for specialized approaches to developmental, neoplastic, and functional problems.
- A. Cooper (1845).The Anatomy and Diseases of the Breast Lea and Blanchard, Philadelphia.
- K. Kratochwil (1987). Epithelium-mesenchyme interactions in the fetal mammary gland. In D. Medina, W. Kidwell, G. Heppner, and E. Anderson (eds.),Cellular and Molecular Biology of Mammary Cancer Plenum Press, New York, pp. 67–80.
- T. Sakakura (1991). New aspects of stroma-parenchyma relations in mammary gland differentiation.Int. Rev. Cytol. 125165–202.
- C. Q. Lin and M. J. Bissell (1993). Multi-faceted regulation of cell differentiation by extracellular matrix.FASEB J. 7737–743.
- W. Imagawa, J. Yang, R. Guzman, and S. Nandi (1994). Control of mammary gland development. In E. Knobil and J. D. Neill (eds.),The Physiology of Reproduction, Vol. 2, 2nd ed., Raven Press, New York, pp. 1033–1065.
- J. M. Williams and C. W. Daniel (1983). Mammary ductal elongation: Differentiation of myoepithelium and basal lamina during branching morphogenesis.Dev. Biol. 97274–290. CrossRef
- J. Russo, B. A. Gusterson, A. E. Rogers, I. H. Russo, S. R. Wellings, and M. J. Zwieten (1990). Comparative study in human and rat mammary tumorigenesis.Lab. Invest. 62244–278.
- R. E. Munford (1963). Changes in the mammary glands of rats and mice during pregnancy, lactation and involution.J. Endocrinol. 281–44.
- L. J. Faulkin, Jr. and K. B. DeOme (1960). Regulation of growth and spacing of gland elements in the mammary fat pad of the C3H mouse.J. Natl. Cancer Inst. 24953–969.
- Y. Friedmann, C. A. Daniel, P. Strickland, and C. W. Daniel (1994).Hox genes in normal and neoplastic mouse mammary gland.Cancer Res. 545981–5985.
- K. B. DeOme, L. J. Faulkin, Jr., H. A. Bern, and P. E. Blair (1959). Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.Cancer Res. 19515–520.
- D. Medina (1982). Mammary tumors. In H. L. Foster, J. D. Small, and J. G. Fox (eds.),The Mouse in Biomedical Research, Vol. IV, Academic Press, New York, pp. 373–396.
- D. Medina (1979). Serial transplantation of chemical carcinogen-induced mouse mammary ductal dysplasias.J. Natl. Cancer Inst. 62397–405.
- C. W. Daniel (1972). Aging in cells during serial propagationin vivo.Adv. Gerontol. Res. 4167–200.
- E. M. Rivera and S. Vijayaraghavan (1982). Proliferation of ductal outgrowths by carcinogen-induced rat mammary tumors in gland-free mammary fat pads.J. Natl. Cancer Inst. 69517–525.
- B. Alston-Mills and E. M. Rivera (1985). Factors influencing the differential growth of rat mammary tumor fragments and cells transplanted in gland-free and gland-containing mammary fat pads.Eur. J. Cancer Clin. Oncol. 101233–1243. CrossRef
- S. P. Ethier and K. C. Cundiff (1987). Importance of extended growth potential and growth factor independence onin vivo neoplastic potential of primary rat mammary carcinoma cells.Cancer Res. 475316–5322.
- K. H. Clifton and M. N. Gould (1985). Clonagen transplantation assay of mammary and thyroid epithelial cells. In C. S. Potten and J. H. Hendry (eds.),Cell Clones Churchill Livingstone, New York, pp. 128–138.
- E. C. Kordon, R. A. McKnight, C. Jhappan, L. Henninghausen, G. Merlino, and G. H. Smith (1995). Ectopic TGFβ1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population.Dev. Biol. (in press).
- D. W. Morris and R. D. Cardiff (1987). The multistep model of mouse mammary tumor development.Adv. Viral Oncol. 7123–140.
- K. Hoshino (1978). Mammary transplantation and its histogenesis in mice. In A. Yokoyama, H. Mizuno, and H. Nagasawa (eds.),Physiology of Mammary Glands. University Park Press, Baltimore, pp. 163–228.
- C. W. Daniel, G. B. Silberstein, K. VanHorn, P. Strickland, and S. Robinson (1989). TGF-β1-induced inhibition of mouse mammary ductal outgrowth: Developmental specificity and characterization.Dev. Biol. 13520–30. CrossRef
- W. Jones, R. C. Hallowes, N. Choongkittaworn, H. L. Hosick, and R. Dils (1983). Isolation of the epithelial subcomponents of the mouse mammary gland for tissue-level culture studies.J. Tissue Culture Meth. 817–25. CrossRef
- S. R. Dundas, M. G. Ormerod, B. A. Gusterson, and M. J. O'Hare (1991). Characterization of luminal and basal cells flow-sorted from the adult rat mammary parenchyma.J. Cell Sci. 100459–471.
- D. Medina, F. Shepherd, and T. Gropp (1978). Enhancement of the tumorigenicity of preneoplastic mammary nodule lines by enzymatic dissociation.J. Natl. Cancer Inst. 601121–1126.
- T. K. Bera, R. C. Guzman, S. Miyamoto, D. K. Panda, M. Sasaki, K. Hanyu, J. Enami, and S. Nandi (1994). Identification of a mammary transforming gene (MAT1) associated with mouse mammary carcinogenesis.Proc. Natl. Acad. Sci. USA 919789–9793.
- B. Wang, W. S. Kennan, J. Yasukawa-Barnes, M. J. Lindstrom, and M. N. Gould (1991). Carcinoma induction following directin situ transfer of v-Ha-ras into rat mammary epithelial cells using replication-defective retrovirus vectors.Cancer Res. 512642–2648.
- S. Coleman and C. W. Daniel (1990). Inhibition of mouse mammary ductal morphogenesis and down-regulation of the EGF receptor by epidermal growth factor.Dev. Biol. 137425–433. CrossRef
- S. R. Wellings, M. M. Jensen, and R. G. Marteum (1975). An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions.J. Natl. Cancer Inst. 55231–274.
- C. W. Welsch, D. H. O'Connor, C. F. Aylsworth, and L. G. Sheffield (1987). Normal but not carcinomatous primary rat mammary epithelium readily transplanted to and maintained in the athymic nude mouse.J. Natl. Cancer Inst. 78557–565.
- R. R. Mehta, J. M. Graves, G. D. Hart, A. Shilkaites, and T. K. Das Gupta (1993). Growth and metastasis of human breast carcinomas with Matrigel in athymic mice.Breast Cancer Res. Treat. 2565–71. CrossRef
- L. Henninghausen (1990). The mammary gland as a bioreactor; production of foreign proteins in milk.Protein Expression Purific. 13–8. CrossRef
- P. A. W. Edwards, C. L. Abram, and J. M. Bradbury, Genetic manipulation of mammary epithelium by transplantation.J. Mammary gland Biol. Neoplasia, this issue.
- The mammary gland: A unique organ for the study of development and tumorigenesis
Journal of Mammary Gland Biology and Neoplasia
Volume 1, Issue 1 , pp 5-19
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- Daniel Medina (1)
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- 1. Department of Cell Biology, Baylor College of Medicine, 77030, Houston, Texas