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Low virulence and immunogenicity in mice and in rabbits of variants ofHerpes simplex virus resistant to 5-iodo-2-deoxyuridine

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Résumé

Par passage en série sur des cellules en culture et en présence de 5-iodo-2-desoxyuridine (IUdR) on a obtenu une souche de virus herpétique résistant à l'IUdR. Cette souche est très peu virulente chez la souris et le lapin, mais est capable de protéger ces animaux contre le virus pathogène d'origine.

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References

  1. B. Loddo, M. L. Schivo andW. Ferrari, Lancet2, 914 (1963).

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Authors and Affiliations

  1. Istituto di Microbiologia II dell'Università, Via G. T. Porcell 12, Cagliari, (Italy)

    M. A. Marcialis, P. La Colla, M. L. Schivo, O. Flore, A. Firinu & B. Loddo

Authors
  1. M. A. Marcialis
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  2. P. La Colla
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  3. M. L. Schivo
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  4. O. Flore
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  5. A. Firinu
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  6. B. Loddo
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Additional information

This work has been supported by a Grant of Consiglio Nazionale delle Ricerche, Roma.

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Marcialis, M.A., La Colla, P., Schivo, M.L. et al. Low virulence and immunogenicity in mice and in rabbits of variants ofHerpes simplex virus resistant to 5-iodo-2-deoxyuridine. Experientia 31, 502–503 (1975). https://doi.org/10.1007/BF02026404

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  • DOI: https://doi.org/10.1007/BF02026404

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