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Acute toxicity of organophosphorus and organochlorine insecticides in laboratory animals

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Summary

The influence of acute poisoning with Dursban (O.P.I.) and D.D.T. (O.cl.I.) on serum enzymes and histopathological examination of the liver, kidney and testes was investigated in albino rats.

Two repeated i.p. injections of Dursban in a dose of half the LD 50 resulted in a significant increase in serum GOT, GPT and alkaline phosphatase activity and a decrease of cholinesterase.

In case of DDT, two doses of 150 mg/kg orally resulted in a significant increase in the activity of serum GPT only, while three doses increased serum GOT and GPT. No significant change was observed in serum alkaline phosphatase and cholinesterase activity.

Regarding the pathological examination it was found that in animals treated with Dursban there was liver necrosis of mid-zonal type and fatty change at the periphery.

In case of DDT the liver cells lost their radial arrangements and showed fatty change. There was cellular infiltration in the centre, mostly mononucleolar cells.

In both insecticides there was necrosis of some of the seminiferous tubules of the testes and cloudy swelling of the convoluted tubules of the kidney.

Histochemical study of the liver in animals treated with Dursban showed that glycogen was deposited at one side of the cell. However, there was depletion of glycogen around the central vein.

In liver treated with DDT there were large globules of fat inside the liver cells, indicating increased fat content compared to control liver, where there were tiny minute droplets of fat.

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References

  1. Bigg, H., G. Garey, Amer. J. clin. Path.30, 191 (1958).

    Google Scholar 

  2. Bogusz, M., T. Borkowski, Analyst98, 190 (1973).

    Article  CAS  Google Scholar 

  3. Chaterjee, A., Endocrinology77, 395 (1965).

    Article  Google Scholar 

  4. Cornish, H. H., W. D. Block, Arch. Environm. Health1, 96 (1960).

    Article  CAS  Google Scholar 

  5. De Bruin, A., R. L. Zielhuis, T. soc. Geneesk45, 128 (1967).

    Google Scholar 

  6. Domschke, W., S. Domschke, Acta hepato-gastroenterol.19, 255 (1972).

    CAS  Google Scholar 

  7. El-Dessoukey, E. A., H. Mikhail Tahani, R. Awadallah, H. Aly Zinat, Nadia A. Kotb, Z. Ernährungswiss.17, 159 (1978).

    Article  CAS  Google Scholar 

  8. Frunder, H., Vop. med. Klin.14, 130 (1968).

    CAS  Google Scholar 

  9. Geike, F., J. Chromat.44, 95 (1969).

    Article  CAS  Google Scholar 

  10. Helmy, F. M., Studies in comparative histochemistry. Ph.D. Thesis, Tulane University (1962).

  11. Kagan, Yu. S., L. M. Sasinovich, L. Ya. Voronia Gig Sanit35, 36 (1971).

    Google Scholar 

  12. King, E. J., A. Armstrong, Canad. med. Ass.31, 376 (1934).

    CAS  Google Scholar 

  13. Kulagin, O. M., Gig. Priman Toksicol Pestits Klin. Otravlenu8, 82 (1970).

    Google Scholar 

  14. Mehani, S., A. El-Habashi, K. Ahmed, Ain Shams med. J.25, 345 (1974).

    Google Scholar 

  15. Menrath, R. L., A. Sharad, K. W. Gray, C. W. Gameron, N. Z. Vet. J.21, 212 (1973).

    Article  CAS  Google Scholar 

  16. Molander, D. W., F. Wroblewski, J. S. Ladue, J. Lab. clin. Med.46, 831 (1955).

    CAS  Google Scholar 

  17. Murphy, S. D., Toxicol. Appl. Pharmacol.7, 833 (1965).

    Article  CAS  Google Scholar 

  18. Murphy, S. D., Toxicol. Appl. Pharmacol.8, 266 (1966).

    Article  CAS  Google Scholar 

  19. Nowell, N. W., I. Chester Jonas, Acta endocrinol.26, 273 (1957).

    CAS  Google Scholar 

  20. Pearse, A. G. E., Histochemistry, Theoretical and Applied, 3rd ed., I: J. and A. Churchill, Ltd (London 1968).

    Google Scholar 

  21. Recknagel, R. O., Pharmacol. Rev.19, 145 (1967).

    CAS  Google Scholar 

  22. Rees, K. R., K. P. Sinha, J. Path. Bact.80, 297 (1960).

    Article  CAS  Google Scholar 

  23. Reitman, S., S. Frankel, Amer. J. clin. Path.28, 56 (1957).

    Article  CAS  Google Scholar 

  24. Sawyer, C. H., J. W. Everett, Endocrinology39, 307 (1946).

    Article  CAS  Google Scholar 

  25. Schmidt, E., F. W. Schmidt, E. Wildhert, Klin. Wschr.36, 280 (1958).

    Article  CAS  Google Scholar 

  26. Singlevich, T. E., J. J. Barboriak, K. Pintar, J. Eur. Toxicol.4, 532 (1971).

    CAS  Google Scholar 

  27. Velrado, J. T., The Endocrinology of Reproduction, p. 79 (New York 1958).

  28. Villela, G. G., W. P. Assis, Rev. Bras. Biol.23, 251 (1963).

    CAS  Google Scholar 

  29. Vorhaus, L. J., R. M. Kark, Amer. J. Med.14, 707 (1953).

    Article  CAS  Google Scholar 

  30. Weiss, L. R., J. Bryant, O. G. Fitzhugh, Toxicol. Appl. Pharmacol.6, 363 (1964).

    Google Scholar 

  31. Wright, F. C., L. M. Hunt, J. S. Palmer, Amer. J. Vet. Res.27, 177 (1966).

    CAS  Google Scholar 

  32. Zemaitis, M. A., K. M. Oberholser, F. E. Greene, Toxicol. Appl. Pharmacol.37, 29 (1976).

    Article  CAS  Google Scholar 

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Author notes

  1. T. H. Mikhail

    Present address: National Research Centre, Dokki, Cairo, Egypt

Authors and Affiliations

  1. National Research Centre, Dokki, Cairo, Egypt

    N. Aggour, R. Awadallah, M. N. Boulos, E. A. El-Dessoukey & A. I. Karima

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  1. T. H. Mikhail
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  2. N. Aggour
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  3. R. Awadallah
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  4. M. N. Boulos
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  5. E. A. El-Dessoukey
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  6. A. I. Karima
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Mikhail, T.H., Aggour, N., Awadallah, R. et al. Acute toxicity of organophosphorus and organochlorine insecticides in laboratory animals. Z Ernährungswiss 18, 258–268 (1979). https://doi.org/10.1007/BF02020516

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