Summary
Both angelicin and psoralen monoadducts formed in vivo in E. coli by near UV light produce lethal and mutagenic effects. However psoralen monoadducts are converted to cross links by higher doses of UV; angelicin monoadducts are not. The relevance of these results to psoralen photosensitization is discussed.
Similar content being viewed by others
Literatur
L. Musajo and G. Rodighiero, Experientia18, 153 (1962).
R. S. Cole, J. Bacteriol.107, 846 (1971).
L. Musajo, P. Visentini, F. Baccichetti and M. A. Razzi, Experientia23, 335 (1967).
R. S. Cole, Proc. nat. Acad. Sci.70, 1064 (1973).
B. D. Reid and I. G. Walker, Biochim. biophys. Acta179, 179 (1969).
E. Ben-Hur and M. M. Elkind, Biochim. biophys. Acta331, 181 (1973).
M. S. Sasaki and A. Tonomura, Cancer Res.33, 1829 (1973).
R. S. Day, A. S. Giuffrida and C. W. Dingman, Mutation Res.33, 311 (1975).
R. S. Cole, Biochim. biophys. Acta254, 30 (1971).
M. J. Ashwood-Smith and E. Grant, Cryobiology11, 160 (1974).
L. Musajo and G. Rodighiero, Photochem. Photobiol.11, 27 (1970).
F. Dall'Acqua, S. Marciani, L. Ciavatta and G. Rodighiero, Z. Naturforsch.26, 561 (1971).
G. Rodighiero, F. Dall'Acqua, S. Marciani, P. Chandra, H. Feller, A. Götz and A. Wacker, Biophysik8, 1 (1972).
G. Colombo, Exp. Cell Res.48, 167 (1967).
R. S. Cole, Biochim. biophys. Acta217, 30 (1970).
R. S. Cole and D. Zusman, Biochim. biophys. Acta224, 660 (1970).
J. W. Drake and J. McGuire, J. Virol.1, 260 (1967).
B. R. Scott and T. Alderson, Mutation Res.12, 29 (1971).
S. Igali, B. A. Bridges, M. J. Ashwood-Smith and B. R. Scott, Mutation Res.9, 21 (1970).
M. M. Matthews, J. Bacteriol.85, 322 (1963).
E. L. Oginsky, G. S. Green, D. F. Griffith and W. L. Fowlks, J. Bacteriol.78, 821 (1959).
B. Nicoletti and G. Trippa, Rc. Accad. naz. Lincei43, 259 (1967).
E. Ben-Hur and M. M. El Kind, Mutation Res.18, 315 (1973).
J. E. Trosko and M. Isoun, Int. J. Radiat. Biol.19, 87 (1971).
H. P. Baden, J. M. Parrington, J. D. A. Delhanty and M. A. Pathak, Biochim. biophys. Acta262, 247 (1972).
J. H. Epstein and K. Fukuyama, Photochem. Photobiol.21, 325 (1975).
M. A. Pathak and D. M. Kramer, Biochim. biophys. Acta195, 197 (1969).
Med. Post11 (26), 1 (1975).
M. J. Ashwood-Smith, E. Grant, Heddle and Friedmann, Mutation Res., in press 1977.
Author information
Authors and Affiliations
Additional information
Supported by the National Research Council of Canada.
Rights and permissions
About this article
Cite this article
Ashwood-Smith, M.J., Grant, E. Conversion of psoralen DNA monoadducts in E. coli to interstrand DNA cross links by near UV light (320–360 nm): Inability of angelicin to form cross links, in vivo. Experientia 33, 384–386 (1977). https://doi.org/10.1007/BF02002841
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02002841